Výsledky vyhledávání

Proof-of-principle that a decoy virus protects oncolytic measles virus against neutralizing antibodies

Autor: Xu C, Goß AV, Dorneburg C, Debatin KM, Wei J, Beltinger C

Publikováno v: Oncolytic Virotherapy, Vol Volume 7, Pp 37-41 (2018)

Chun Xu,1,2,* Annika Verena Goß,1,* Carmen Dorneburg,1 Klaus-Michael Debatin,1 Jiwu Wei,2 Christian Beltinger1 1Department of Pediatrics and Adolescent Medicine, Section of Experimental Pediatric Oncology, University Medical Center Ulm, Ulm, Germany

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::a892350798d4bbc1b1db1e58e1226215
https://www.dovepress.com/proof-of-principle-that-a-decoy-virus-protects-oncolytic-measles-virus-peer-reviewed-article-OV

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Akademický článek

Juvenile dermatomyositis (JDM) sine myositis

Autor: Schulz A, Pfeiffer C, Mohr V, Schuetz C, Debatin KM

Publikováno v: Pediatric Rheumatology Online Journal, Vol 9, Iss Suppl 1, p P62 (2011)

Externí odkaz: https://doaj.org/article/c406042bfb77466896ba2e960b86e194

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LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis

Autor: Dorneburg, C, Fischer, M, Barth, TFE, Mueller-Klieser, W, Hero, B, Gecht, J, Carter, DR, de Preter, K, Mayer, B, Christner, L, Speleman, F, Marshall, GM, Debatin, KM, Beltinger, C

© 2018 American Association for Cancer Research. Purpose: To investigate whether lactate dehydrogenase A (LDHA), an important component of the LDH tetramer crucial for aerobic glycolysis, is associated with patient outcome and constitutes a therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::4d8bc160803f67c7eefe1fbdd7d19068
https://hdl.handle.net/10453/133058

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An old psychiatric drug, olanzapine, provides antineoplastic activity against glioblastoma cells when applied as a single-agent or in combination with temozolomide

Autor: Karpel-Massler, G, Kast, RE, Westhoff, MA, Dwucet, A, Welscher, N, Nonnenmacher, L, Hlavac, M, Siegelin, MD, Wirtz, CR, Debatin, KM, Halatsch, ME

Publikováno v: 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20150607-20150610; Karlsruhe; DOCMI.09.06 /20150602/

Objective: The continuously poor prognosis of patients with glioblastoma urges the discovery of more effective therapeutics. Repurposing of already existing drugs involves the clinical application of old agents with previously not known or not utiliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0177359307045af53de3bbc832a111b2

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Erlotinib and NSC23766 yield a synergistic antiproliferative effect in human glioblastoma cell lines by inhibiting cell cycle progression

Autor: Karpel-Massler, G, Westhoff, MA, Dwucet, A, Wirtz, CR, Debatin, KM, Halatsch, ME

Publikováno v: 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20130526-20130529; Düsseldorf; DOCMI.13.05 /20130521/

Objective: We have previously reported that combined inhibition of the epidermal growth factor receptor by erlotinib and of RAC1 by NSC23766 yielded a synergistic antiproliferative effect on established and primary glioblastoma cells. The current stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d998cc107155c33ee0506b5a63927d68

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Molekulare Charakterisierung von Hochrisiko ALL und Identifikation neuer Therapiestrategien in einem präklinischen ALL-Xenograftmodell

Autor: Meyer, LH, Eckhoff, SM, Hasan, N, Queudeville, M, Debatin, KM

Publikováno v: Süddeutsche Tage der Kinder-und Jugendmedizin; 61. Jahrestagung der Süddeutschen Gesellschaft für Kinder-und Jugendmedizin und der Süddeutschen Gesellschaft für Kinderchirurgie und dem Berufsverband für Kinder-und Jugendärzte-Landesverband Bayern; 20120504-20120506; München; DOC12sgkjFV6 /20120411/

Etwa 80% aller Patienten mit ALL können geheilt werden, jedoch erleidet etwa jeder fünfte ein Rezidiv der Erkrankung. Dies ist, insbesondere bei frühem Auftreten, mit einer schlechteren Prognose verbunden. Die Behandlung pädiatrischer ALL Patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31a31afef4c2de3a4e3a7e1ecb8a3d1

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Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS

Autor: Dechant, Mj, Scheuerpflug, Cg, Pauly, E, Van Der Werff Ten Bosch, Jutte, Debatin, Km, Fellenberg, J

BACKGROUND: Apoptosis is known to be a crucial process involved in embryogenesis, development and homeostasis of the immune system. Impaired apoptosis causes dysfunction of lymphocyte homeostasis, growth advantage of tumor cells as well as resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3848::d97c508189d4fd2ae46e9e469b2a11c3
https://hdl.handle.net/20.500.14017/368df028-4911-4daf-9c9e-54f9ab6da912

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