Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Debarshi Pratihar"'
Autor:
Debarshi Pratihar, Damien Maura, Cheng Ji, Indrajeet Sharma, J P Coleman, L. Lynn Hudson, Derek S. Tan, Tezcan Guney, Laurence G. Rahme, Everett C. Pesci
Publikováno v:
ACS Chemical Biology
The Gram-negative bacterial pathogen Pseudomonas aeruginosa uses three interconnected intercellular signaling systems regulated by the transcription factors LasR, RhlR, and MvfR (PqsR), which mediate bacterial cell-cell communication via small-molecu
Publikováno v:
Tetrahedron Letters. 52:4985-4988
Alkenylalumination of aldehydes with [α-(ethoxycarbonyl)-β-(t-butyldimethylsilyloxyalkyl)alkenyl]diisobutylaluminum provides the corresponding α-Z-alkylidene-β′-hydroxy esters, which upon protection and treatment with trifluoroacetic acid lacto
Autor:
C. Max Schmidt, P. Veeraraghavan Ramachandran, Matthew Walters, Hari Nair, Huangbing Wu, Debarshi Pratihar, Sadie Smith, Michele T. Yip-Schneider
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6620-6623
A selected series of racemic α-methylene-γ-butyrolactones (AMGBL) were synthesized via allylboration and screened against three human pancreatic cancer cell lines (Panc-1, MIA PaCa-2, and BxPC-3). This systematic study established a discernible rel
Publikováno v:
Organic Letters. 9:4753-4756
Alkenylalumination of substituted styrene oxides with [α-(ethoxycarbonyl)alkenyl]diisobutylaluminum, in the presence of BF3·Et2O, affords the corresponding (Z)-α-alkylidene-γ-aryl-γ-hydroxy esters in 81−100% Z-selectivity. Chromatographic sepa
Autor:
Debarshi Pratihar, Ramachandran Pv
Publikováno v:
Organic Letters. 9:2087-2090
The strength of the Lewis or Brønsted acids controls the formation of either beta,gamma-disubstituted-alpha-methylene-gamma-butyrolactones or gamma-substituted-alpha-alkylidene-gamma-butyrolactones via the lactonization or oxonia cope rearrangement-
Publikováno v:
Organic Letters. 8:3877-3879
[reaction; see text] A general and practical procedure for the highly diastereoselective preparation of either the cis- or trans-beta,gamma-disubstituted-gamma-butyrolactones by appropriate choice of Lewis or Bronsted acid catalysts during crotylbora
Publikováno v:
ChemInform. 43
Starting from aldehydes (II), the synthesis of butenolide and dihydropyranone structures is achieved by alkenylalumination, O-protection and lactamization.
Autor:
Debarshi Pratihar, P. Veeraraghavan Ramachandran, C. Max Schmidt, Michele T. Yip-Schneider, Huangbing Wu, Sadie Smith, Matthew Walters, Hari Nair
Publikováno v:
ChemInform. 42
A series of racemic α-methylene-γ-butyrolactones is synthesized and screened against three human pancreatic cancer cell lines.
Publikováno v:
ChemInform. 40
A convenient and general, reagent-controlled, diastereo- and enantioselective aldol reaction of diisopinocampheylboron enolates of esters, followed by reduction, has been developed as an alternative to crotylboration-ozonolysis. This protocol was the
Publikováno v:
Organic letters. 11(7)
A convenient and general, reagent-controlled, diastereo- and enantioselective aldol reaction of diisopinocampheylboron enolates of esters, followed by reduction, has been developed as an alternative to crotylboration-ozonolysis. This protocol was the