Defining the role of TRPM4 in broadly responsive taste receptor cells

Autor: Debarghya Dutta Banik, Kathryn F. Medler

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are sent to the brain. We have previously identified a subpopulation of Type III taste cells that are broadly responsive (BR) and resp

Externí odkaz: https://doaj.org/article/deec5ba65a49444da2c00c437ca292da

EGR4 is critical for cell-fate determination and phenotypic maintenance of geniculate ganglion neurons underlying sweet and umami taste

Autor: Debarghya Dutta Banik, Louis J. Martin, Tao Tang, Jonathan Soboloff, Warren G. Tourtellotte, Brian A. Pierchala

Publikováno v: Proceedings of the National Academy of Sciences. 120

The sense of taste starts with activation of receptor cells in taste buds by chemical stimuli which then communicate this signal via innervating oral sensory neurons to the CNS. The cell bodies of oral sensory neurons reside in the geniculate ganglio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfeddeee2934f7c6e796b919ba380ea3
https://doi.org/10.1073/pnas.2217595120

Taste Receptor Signaling

Autor: Debarghya, Dutta Banik, Kathryn F, Medler

Publikováno v: Handbook of experimental pharmacology. 275

All organisms have the ability to detect chemicals in the environment, which likely evolved out of organisms' needs to detect food sources and avoid potentially harmful compounds. The taste system detects chemicals and is used to determine whether po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9df4c179690ada0ff313f41d454a0b64
https://pubmed.ncbi.nlm.nih.gov/33580388

Differential Effects of Diet and Weight on Taste Responses in Diet-Induced Obese Mice

Autor: Laura E. Martin, Zachary C. Ahart, Bailey R. Kemp, Ann-Marie Torregrossa, Stefan G. E. Roberts, Debarghya Dutta Banik, Kathryn F. Medler

Publikováno v: Obesity (Silver Spring)
Ahart, Z C, Martin, L E, Kemp, B R, Banik, D D, Roberts, S G E, Torregrossa, AM & Medler, K F 2020, ' Differential Effects of Diet and Weight on Taste Responses in Diet-Induced Obese Mice ', Obesity, vol. 28 (2020), no. 2, pp. 284-292 . https://doi.org/10.1002/oby.22684

The ever growing obesity epidemic has created a need to develop a better understanding of the underlying mechanisms responsible for this condition. Appetite and consumption are directly influenced by the taste system which determines if potential foo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27518547f1cbc8cf798ff421b40c391e
https://pubmed.ncbi.nlm.nih.gov/31891242

TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells

Autor: Laura E. Martin, Kathryn F. Medler, Ann-Marie Torregrossa, Debarghya Dutta Banik, Marc Freichel

Publikováno v: Proceedings of the National Academy of Sciences. 115

Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are sent to the brain. Transient receptor potential melastatin 5 (TRPM5), a sodium-selective TRP channel, functions as a common downst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc2fc69522dc85e548e221011ab48e6
https://doi.org/10.1073/pnas.1718802115