Výsledky vyhledávání - "Debangsu, Sil"

Akademický článek

Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Autor: Gang Liu, Debangsu Sil, Nunziata Maio, Wing-Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of whic

Externí odkaz: https://doaj.org/article/e72a170c1c0d4aa795c47a4475b86629

Zobrazit plný text záznamu

What Is the Right Level of Activation of a High-Spin {FeNO}7 Complex to Enable Direct N–N Coupling? Mechanistic Insight into Flavodiiron NO Reductases

Autor: Hai T. Dong, Stephanie Camarena, Debangsu Sil, Michael O. Lengel, Jiyong Zhao, Michael Y. Hu, E. Ercan Alp, Carsten Krebs, Nicolai Lehnert

Publikováno v: J Am Chem Soc

Flavodiiron nitric oxide reductases (FNORs), found in pathogenic bacteria, are capable of reducing nitric oxide (NO) to nitrous oxide (N(2)O) to detoxify NO released by the human immune system. Previously, we reported the first FNOR model system that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2995106944b78bb73b7289ef8528d7
https://doi.org/10.1021/jacs.2c04292

Zobrazit plný text záznamu

Synergistic Binding of the Halide and Cationic Prime Substrate of the l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States

Autor: Jeffrey W. Slater, Monica E. Neugebauer, Molly J. McBride, Debangsu Sil, Chi-Yun Lin, Bryce J. Katch, Amie K. Boal, Michelle C.Y. Chang, Alexey Silakov, Carsten Krebs, J. Martin Bollinger

Publikováno v: bioRxiv

An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl−or Br−), the halogenation target (“prime substrate”), and dioxygen. In well-studied cases, the three non-gaseous substrates must bind to activate the enzyme’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b9fbd5470ea79412bbe4a20efb2a5d
https://doi.org/10.1101/2023.05.02.539147

Zobrazit plný text záznamu

Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate

Autor: Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, Jeffrey W. Slater, Monica E. Neugebauer, Michelle C. Y. Chang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger

Publikováno v: Biochemistry

The enzyme BesC from the β-ethynyl-L-serine biosynthetic pathway in Streptomyces cattleya fragments 4-chloro-L-lysine (produced from L-Lysine by BesD) to ammonia, formaldehyde, and 4-chloro-L-allylglycine and can analogously fragment L-Lys itself. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f6540199357ff8469be639a7484ad9
https://doi.org/10.1021/acs.biochem.1c00774

Zobrazit plný text záznamu

In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1

Autor: Douglas M. Warui, Debangsu Sil, Kyung-Hoon Lee, Syam Sundar Neti, Olga A. Esakova, Hayley L. Knox, Carsten Krebs, Squire J. Booker

Publikováno v: ACS biomed chem Au. 2(5)

Lipoyl synthase (LS) catalyzes the last step in the biosynthesis of the lipoyl cofactor, which is the attachment of sulfur atoms at C6 and C8 of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d66aa4221a8eee66c6588872b9862db
https://pubmed.ncbi.nlm.nih.gov/36281303

Zobrazit plný text záznamu

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

Autor: Theodore C. Pierson, Yan Li, Debangsu Sil, W. Marston Linehan, Bernard A. P. Lafont, Tracey A. Rouault, Carsten Krebs, J. Martin Bollinger, Nunziata Maio

Publikováno v: Science

Mind your metals Iron–sulfur clusters are important cofactors for proteins involved in metabolism and electron transfer but are also sometimes found in enzymes involved in transcription and replication of DNA. In vitro expression of such enzymes ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cbd7801cd707be651d4f387a5b49a5
https://doi.org/10.1126/science.abi5224

Zobrazit plný text záznamu

Plný text ve formátu HTML

Fluoro-bridged dimanganese(III) porphyrin dimer: Effect of intermacrocyclic interactions in modulating metal spin state

Autor: Sankar Prasad Rath, Sayantani Banerjee, Debangsu Sil, Sudip Ghosh

Publikováno v: Journal of Porphyrins and Phthalocyanines. 25:522-532

The synthesis, structure, and spectroscopic properties of a remarkably deformed dimanganese(III)-[Formula: see text]-fluoro porphyrin dimer in connection to its diiron(III) [Formula: see text]-fluoro and [Formula: see text]-hydroxo counterparts is re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b84b52eecadb7800a50f757946198e8c
https://doi.org/10.1142/s1088424621500401

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání