Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Debadyuti, Ghosh"'
Autor:
Melissa R. Soto, Mae M. Lewis, Jasmim Leal, Yuting Pan, Rashmi P. Mohanty, Arian Veyssi, Esther Y. Maier, Brittany J. Heiser, Debadyuti Ghosh
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102375- (2024)
For cystic fibrosis patients, a lung-targeted gene therapy would significantly alleviate pulmonary complications associated with morbidity and mortality. However, mucus in the airways and cell entry pose huge delivery barriers for local gene therapy.
Externí odkaz:
https://doaj.org/article/e8f77c73d20b47b7862c329c25cf9246
Autor:
Mae M. Lewis, Melissa R. Soto, Esther Y. Maier, Steven D. Wulfe, Sandy Bakheet, Hannah Obregon, Debadyuti Ghosh
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 6, Pp n/a-n/a (2023)
Abstract Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for loca
Externí odkaz:
https://doaj.org/article/09f8130523b74f9c9988e235a0ec8305
Autor:
Laxmicharan Samineni, Sophie De Respino, Yu-Ming Tu, Ratul Chowdhury, Rashmi Prava Mohanty, Hyeonji Oh, Michael Geitner, Claire Hartwig Alberg, Abigail Roman-White, Sarine McKinzie, Camila Lemus, Joy Massey, Debadyuti Ghosh, Thomas M. Truskett, Stephanie Velegol, Manish Kumar
Publikováno v:
npj Clean Water, Vol 5, Iss 1, Pp 1-12 (2022)
Abstract Pathogen contamination of water has a massive impact on global human health. In particular, viruses pose unique challenges to water treatment techniques due to their small size and presence in water as both individual virions and when absorb
Externí odkaz:
https://doaj.org/article/e2db674147694c6c830db3c36cb2e6c1
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1042 (2020)
Messenger RNA is a class of promising nucleic acid therapeutics to treat a variety of diseases, including genetic diseases. The development of a stable and efficacious mRNA pulmonary delivery system would enable high therapeutic concentrations locall
Externí odkaz:
https://doaj.org/article/e2b681aa87a04ae595442d25ab47190e
Publikováno v:
Pharmaceutical Research. 38:1793-1804
Bacteriophage (phage) therapy has re-gained attention lately given the ever-increasing prevalence of multi-drug resistance ‘super-bugs’. To develop therapeutic phage into clinically usable drug products, the strategy of solidifying phage formulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01ae1276068fb6271b66fc5bfdb6e927
https://doi.org/10.1007/s11095-021-03111-y
https://doi.org/10.1007/s11095-021-03111-y
Publikováno v:
Advanced Drug Delivery Reviews. 197:114825
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffa2a6666cf4b9b1000c6e1b9b7a566b
https://doi.org/10.1016/j.addr.2023.114825
https://doi.org/10.1016/j.addr.2023.114825
Autor:
Steven Wulfe, Xinquan Liu, Rashmi P. Mohanty, Debadyuti Ghosh, Xiujuan Peng, Esther Y. Maier, Kyaw L. Aung, Agnieszka P. Looney
Publikováno v:
Journal of Controlled Release. 328:1-12
To harness the intrinsic transport properties of albumin yet improve the therapeutic index of current in situ albumin-binding prodrugs, we developed albumin-drug conjugates with a controlled loading that achieved better antitumor efficacy. Here, mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9479ec4f87ff3a9bdeb5addb0d84c19
https://doi.org/10.1016/j.jconrel.2020.08.015
https://doi.org/10.1016/j.jconrel.2020.08.015
Publikováno v:
Acta Biomaterialia. 113:240-251
Drug carriers achieve poor and heterogeneous distribution within solid tumors due to limited transport through the tumor extracellular matrix (ECM). The tumor ECM forms a net negatively charged network that interacts with and hinders the transport of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f6ee1d7331e21c99171a30f71bdb79
https://doi.org/10.1016/j.actbio.2020.04.051
https://doi.org/10.1016/j.actbio.2020.04.051
Publikováno v:
Pharmaceutical research. 38(10)
Bacteriophage (phage) therapy has re-gained attention lately given the ever-increasing prevalence of multi-drug resistance 'super-bugs'. To develop therapeutic phage into clinically usable drug products, the strategy of solidifying phage formulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6a725e450b166511f654cffaf86cc8f
https://pubmed.ncbi.nlm.nih.gov/34697726
https://pubmed.ncbi.nlm.nih.gov/34697726
Autor:
Xinquan Liu, Debadyuti Ghosh
Publikováno v:
International Journal of Nanomedicine. 14:6589-6600
Background The RAS family of oncogenes (KRAS, HRAS, NRAS) are the most frequent mutations in cancers and regulate key signaling pathways that drive tumor progression. As a result, drug delivery targeting RAS-driven tumors has been a long-standing cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa04b063cd02c1ff6d32cc5513708055
https://doi.org/10.2147/ijn.s212861
https://doi.org/10.2147/ijn.s212861