Zobrazeno 1 - 10
of 652
pro vyhledávání: '"Death-associated protein 6"'
Autor:
Sung-Min Kim, Won-Hee Hur, Byung-Yoon Kang, Sung-Won Lee, Pu-Reun Roh, Dong-Jun Park, Pil-Soo Sung, Seung-Kew Yoon
Publikováno v:
Cells, Vol 10, Iss 7, p 1742 (2021)
Transforming growth factor-β (TGF-β) has been identified as an inducer of hepatocyte epithelial–mesenchymal transition (EMT), which triggers liver fibrosis. Death-associated protein 6 (Daxx) is known to be associated with the TGF-β-induced apopt
Externí odkaz:
https://doaj.org/article/1520a5fd9e724b83b7221d7359bf01e7
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1585-1592
Tyrosine kinase 2 (Tyk2) is a member of the Janus family of protein tyrosine kinases (Jaks). Tyk2 associates with interferon (IFN)-α, IFN-β, interleukin (IL)-6, IL-10, IL-12, and IL-23 receptors and mediates their downstream signaling pathways. Bas
Autor:
Guixin Zhu, Ronen Marmorstein, Xiaolu Yang, Liming Tao, JiaBei Lin, Trisha Agrawal, Sixiang Yu, Liangqian Huang, James Shorter
Publikováno v:
Nature. 597:132-137
Protein quality control systems are crucial for cellular function and organismal health. At present, most known protein quality control systems are multicomponent machineries that operate via ATP-regulated interactions with non-native proteins to pre
Autor:
Muhammet Nafi Civan, Ahmet Bekar, Mevlut Ozgur Taskapilioglu, Omer Gokay Argadal, Pinar Eser Ocak, Secil Ak Aksoy, Ismail Seckin Kaya, Sahsine Tolunay, Cagla Tekin, Melis Mutlu, Berrin Tunca, Hasan Kocaeli
Publikováno v:
Neurological Research. 43:916-925
Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogene
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-4 (2021)
The PCAWG Consortium has recently released an unprecedented set of tumor whole genome sequence (WGS) data from 2,658 cancer patients across 38 different primary tumor sites1. WGS is able to document the quantity and distribution of telomeric repeats2
Autor:
Pil-Soo Sung, Sung Min Kim, Byung-Yoon Kang, Wonhee Hur, Dong-Jun Park, Seung Kew Yoon, Sung Won Lee, Pu-Reun Roh
Publikováno v:
Cells
Volume 10
Issue 7
Cells, Vol 10, Iss 1742, p 1742 (2021)
Volume 10
Issue 7
Cells, Vol 10, Iss 1742, p 1742 (2021)
Transforming growth factor-β (TGF-β) has been identified as an inducer of hepatocyte epithelial–mesenchymal transition (EMT), which triggers liver fibrosis. Death-associated protein 6 (Daxx) is known to be associated with the TGF-β-induced apopt
Autor:
Valentina Loi, Didier Portilla, Sundararaman Swaminathan, Yogesh Scindia, Elizabeth Ghias, Ewa Wlazlo, Sylvia Cechova, Joseph Leeds, Jonathan Ledesma
Publikováno v:
Am J Physiol Renal Physiol
Acute kidney injury (AKI) is a frequent complication of sepsis and an important cause of morbidity and mortality worldwide. A cornerstone of sepsis-associated AKI is dysregulated inflammation, leading to increased tissue oxidative stress and free rad
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-12 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Recurrence of estrogen receptor (ER)-positive breast tumors despite curative-intent adjuvant therapy is thought to be due to enrichment of tumor initiating cells (TIC) during endocrine therapy (ET). Recently, it was identified that by antagonizing th
Autor:
Christine Davis, Sandro Santagata, Fausto J. Rodriguez, Gary L. Gallia, Wenya Linda Bi, Christopher M. Heaphy, Shannon Coy
Publikováno v:
Mod Pathol
Telomeres are nucleoprotein complexes located at the termini of eukaryotic chromosomes that prevent exonucleolytic degradation and end-to-end chromosomal fusions. Cancers often have critically shortened, dysfunctional telomeres contributing to genomi
Autor:
Benedikt Brors, Elisa M. Wecht, Matthias Selbach, Katharina Kiesel, Carl Herrmann, David T.W. Jones, Umut H. Toprak, Peter F. Ambros, Stefan M. Pfister, Lina Sieverling, Michal Nadler-Holly, Kai-Oliver Henrich, Moritz Gartlgruber, Konstantin Okonechnikov, Lars Feuerbach, Larissa Savelyeva, Olaf Witt, Matthias Fischer, Sabine Hartlieb, Young-Gyu Park, Carolina Rosswog, Karsten Rippe, Naveed Ishaque, Sabine Taschner-Mandl, Richard Volckmann, Frank Westermann, Barbara Hero, Matthias Ziehm, Elke Pfaff, Jan Koster
Publikováno v:
Nature communications, 12(1):1269. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6665f89ac40c303aa266458cd0db796d
https://pure.amc.nl/en/publications/alternative-lengthening-of-telomeres-in-childhood-neuroblastoma-from-genome-to-proteome(12f60af3-b689-4f7f-8afe-1cadcf29071b).html
https://pure.amc.nl/en/publications/alternative-lengthening-of-telomeres-in-childhood-neuroblastoma-from-genome-to-proteome(12f60af3-b689-4f7f-8afe-1cadcf29071b).html