Exploring the Scope of Asymmetric Synthesis of β-Hydroxy-γ-lactams via Noyori-type Reductions.

Autor: Lynch D; Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork , Cork, Ireland., Deasy RE; Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork , Cork, Ireland., Clarke LA; Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork , Cork, Ireland., Slattery CN; Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork , Cork, Ireland., Khandavilli UB; Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork , Cork, Ireland., Lawrence SE; Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork , Cork, Ireland., Maguire AR; Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork , Cork, Ireland., Magnus NA; Small Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Moynihan HA; Eli Lilly SA, Dunderrow, Kinsale, County Cork, Ireland.

Publikováno v: Organic letters [Org Lett] 2016 Oct 07; Vol. 18 (19), pp. 4978-4981. Date of Electronic Publication: 2016 Sep 22.

Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.

Autor: Slattery CN; Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland., Deasy RE, Maguire AR, Kopach ME, Singh UK, Argentine MD, Trankle WG, Scherer RB, Moynihan H

Publikováno v: The Journal of organic chemistry [J Org Chem] 2013 Jun 21; Vol. 78 (12), pp. 5955-63. Date of Electronic Publication: 2013 Jun 06.