Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dearbhla M Murphy"'
Autor:
Donal J Cox, Sarah A Connolly, Cilian Ó Maoldomhnaigh, Aenea AI Brugman, Olivia Sandby Thomas, Emily Duffin, Karl M Gogan, Oisin Ó Gallchobhair, Dearbhla M Murphy, Sinead A O'Rourke, Finbarr O'Connell, Parthiban Nadarajan, James J Phelan, Laura E Gleeson, Sharee A Basdeo, Joseph Keane
Publikováno v:
eLife, Vol 13 (2024)
Airway macrophages (AM) are the predominant immune cell in the lung and play a crucial role in preventing infection, making them a target for host directed therapy. Macrophage effector functions are associated with cellular metabolism. A knowledge ga
Externí odkaz:
https://doaj.org/article/9c3246ecbdeb45c6a9668ba8b1cd623a
Autor:
Kiran Singh, Sita Cogan, Stefan Elekes, Dearbhla M Murphy, Sinead Cummins, Rory Curran, Zaneta Najda, Margaret R Dunne, Gráinne Jameson, Siobhan Gargan, Seamus Martin, Aideen Long, Derek G Doherty
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271463 (2022)
γδ T cells are thought to contribute to immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanisms by which they are activated by the virus are unknown. Using flow cytometry, we investigated if the two most ab
Externí odkaz:
https://doaj.org/article/5f8051546359488d8f85aea2cdba58af
Autor:
Dearbhla M. Murphy, Donal J. Cox, Sarah A. Connolly, Eamon P. Breen, Aenea A.I. Brugman, James J. Phelan, Joseph Keane, Sharee A. Basdeo
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Background Heterologous effects of vaccines are mediated by “trained immunity,” whereby myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened responses to subsequent insults. Adenovirus vaccine vector has been r
Externí odkaz:
https://doaj.org/article/24b44d5422e842b18d691bd5b2e4fc5e
Publikováno v:
Parasitology. 148:539-549
The soil-transmitted helminthAscaris lumbricoidesinfects ~800 million people worldwide. Some people are heavily infected, harbouring many worms, whereas others are only lightly infected. The mechanisms behind this difference are unknown. We used a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c846fa7cb3d75f2f19df00594e854b16
https://doi.org/10.1017/s0031182021000020
https://doi.org/10.1017/s0031182021000020
Autor:
Seónadh O'Leary, Kate McQuaid, Lorraine Thong, Joseph Keane, Stephen V. Gordon, Gina Leisching, Dearbhla M. Murphy, Morgane Mitermite, Cilian Ó Maoldomhnaigh, Karl M. Gogan, Sharee A. Basdeo, Donal J. Cox, James J. Phelan, Amy M. Coleman
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4677ad2a17db5e38201228d387287c4e
http://europepmc.org/articles/PMC8526932
http://europepmc.org/articles/PMC8526932
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
The burgeoning field of innate immune training, also called trained immunity, has given immunologists new insights into the role of innate responses in protection against infection and in modulating inflammation. Moreover, it has led to a paradigm sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb705ac496c3f3355cddc4a487402b5
Autor:
Gwendoline, Deslyper, Dearbhla M, Murphy, Oluyomi A, Sowemimo, Celia V, Holland, Derek G, Doherty
Publikováno v:
Parasitology. 148(5)
The soil-transmitted helminth Ascaris lumbricoides infects ~800 million people worldwide. Some people are heavily infected, harbouring many worms, whereas others are only lightly infected. The mechanisms behind this difference are unknown. We used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8777479a0c2301e7388ba8f0607c0124
https://pubmed.ncbi.nlm.nih.gov/33431071
https://pubmed.ncbi.nlm.nih.gov/33431071
Autor:
Dearbhla M. Murphy, Melissa J. Conroy, John V. Reynolds, Margaret R. Dunne, Eimear Mylod, Emma K. Foley, Derek G. Doherty, Anshul Bhardwaj, Noel E Donlon, Ashanty M. Melo, Vivienne Fitzgerald, Joanne Lysaght
Publikováno v:
Clinical Immunology. 229:108797
The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) is an obesity-associated malignancy with increasing prevalence, dismal prognosis, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e1d0ae595f30281c28403be21ff536
https://doi.org/10.1016/j.clim.2021.108797
https://doi.org/10.1016/j.clim.2021.108797
Autor:
Mieszko M. Wilk, Aideen C. Allen, Alicja Misiak, Lisa Borkner, Dearbhla M. Murphy, Kingston H. G. Mills
Publikováno v:
Mucosal immunology. 11(6)
Current acellular pertussis (aP) vaccines induce strong antibody and Th2 responses but fail to protect against nasal colonization and transmission of Bordetella pertussis. Furthermore, immunity wanes rapidly after immunization. We have developed a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c94b63a989a398455a34e12809f2cf1
https://pubmed.ncbi.nlm.nih.gov/30127384
https://pubmed.ncbi.nlm.nih.gov/30127384
Autor:
Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Externí odkaz:
https://doaj.org/article/a9b01451cc7f44639429c99ff0a2bc3b