Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Deanne Stolarik"'
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1
https://doi.org/10.1158/1535-7163.c.6543327.v1
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290
https://doi.org/10.1158/1535-7163.22522290
Autor:
Niraj S. Trasi, Hitesh S. Purohit, Geoff G. Z. Zhang, Lynne S. Taylor, Wenqing Gao, DeAnne Stolarik, Gary J. Jenkins, Donald J. Osterling
Publikováno v:
Molecular Pharmaceutics. 16:3617-3625
Crystallization of drug from an amorphous formulation is expected to negatively impact its bioperformance following oral delivery. In evaluating this in vivo, neat crystalline drug is typically mixed with the amorphous formulation. However, this appr
Autor:
Gary J. Jenkins, Donald J. Osterling, Lynne S. Taylor, Xiaochun Lou, Geoff G. Z. Zhang, DeAnne Stolarik, Wenqing Gao, Venecia R Wilson
Publikováno v:
Journal of Controlled Release. 292:172-182
Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited absorption in vivo. Given the low aqueous solubility of this compound, it was of interest to evaluate amorphous formulations in vitro and in vivo. Amorphous solid
Autor:
Darren C. Phillips, Gary J. Jenkins, Richard S. Hong, Chang H. Park, Richard A. Marks, Rohinton P. Edalji, Russell A. Judge, Geoff G. Z. Zhang, Nathaniel D. Catron, Jie Chen, Ahmed Salem, Ahmad Y. Sheikh, John C. Kalvass, Kaid C. Harper, Rajeev M. Menon, Kennan C. Marsh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Ahmed A. Suleiman, Yu-Ming Pu, Yi Shi, Keith M. Fournier, Zhi-Fu Tao, DeAnne Stolarik, Shuang Chen, Orlando F. Bueno, Xilu Wang, Jianguo Ji, Yi-Yin Ku, Andrew J. Souers, Joel D. Leverson, Russell C. Klix, Steven W. Elmore
Publikováno v:
Molecular cancer therapeutics. 20(6)
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Autor:
Geoff G. Z. Zhang, Kevin J. Edgar, Venecia R Wilson, Brittany L.B. Nichols, Xiaochun Lou, Gary J. Jenkins, Yifan Dong, Lynne S. Taylor, DeAnne Stolarik, Donald J. Osterling
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Amorphous solid dispersion (ASD) is a widely employed formulation technique for drugs with poor aqueous solubility. Polymers are integral components of ASDs, but mechanisms by which polymers lead to the generation and maintenance of supersaturated so
Autor:
Eric A. Voight, John T. Randolph, Daniel A.J. Bow, James N Newton, Brice E Uno, Greszler Stephen N, David A. Degoey, DeAnne Stolarik, Kenneth M Gleason, Cecilia Van Handel
Publikováno v:
Journal of medicinal chemistry. 63(19)
A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl l
Autor:
Preethi Krishnan, Rodger F. Henry, Christopher C. Marvin, Tatyana Dekhtyar, Rolf Wagner, John T. Randolph, A. Chris Krueger, David A. Degoey, Vincent Peterkin, Michelle Irvin, Geoff T. Halvorsen, Jason P. Shanley, Heyman Howard R, Eric A. Voight, Robert A. Carr, Cecilia Van Handel, Tongmei Li, Brian S. Brown, Daniel A.J. Bow, Hui-Ju Chen, DeAnne Stolarik
Publikováno v:
Bioorganicmedicinal chemistry. 28(1)
Download : Download high-res image (149KB) Download : Download full-size image Hepatitis C virus (HCV) nucleoside inhibitors have been a key focus of nearly 2 decades of HCV drug research due to a high barrier to drug resistance and pan-genotypic act
Autor:
Bruce E. Leroy, Laura Breidenbach, Amanda Olson, Steven Cassar, Heather Britton, Katja Hempel, Xin Huang, DeAnne Stolarik, Pankajkumar Sancheti, Karsten Wicke, Clarissa Woody
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:56-63
Introduction Unanticipated effects on the central nervous system are a concern during new drug development. A larval zebrafish locomotor assay can reveal seizure liability of experimental molecules before testing in mammals. Relative absorption of co
Autor:
Nelson Lissa T, Tatyana Dekhtyar, DeAnne Stolarik, Thomas Reisch, Warren M. Kati, Donner Pamela L, Tami Pilot-Matias, Sachin V. Patel, Rolf Wagner, Preethi Krishnan, Douglas K. Hutchinson, Todd W. Rockway, Neeta Mistry, David W A Beno, Rubina Mondal, Clarence J. Maring, John T. Randolph, Charles A. Flentge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5462-5467
Research toward a next-generation HCV NS5A inhibitor has identified fluorobenzimidazole analogs that demonstrate potent, broad-genotype in vitro activity against HCV genotypes 1-6 replicons as well as HCV NS5A variants that are orders of magnitude le