Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Deanne Hebrink"'
Autor:
Marcel Wuethrich, Deanne Hebrink, Theodore J. Kottom, Bernd Lepenies, João T. Monteiro, Lucas Dos Santo Dias, Eva M. Carmona, Andrew H. Limper
Publikováno v:
Journal of Medical Microbiology. 68:1649-1654
Myeloid C-type lectin receptors (CLRs) are innate immune recognition molecules that bind to microorganisms via their carbohydrate recognition domains. In this study, we utilized a library of CLRs that recognize fungal mannans. We used this library to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad224ab96214ea8fadbc936dfb6508f5
https://doi.org/10.1099/jmm.0.001062
https://doi.org/10.1099/jmm.0.001062
Publikováno v:
Journal of Medical Microbiology. 67:1772-1777
The importance of lung macrophages in Pneumocystis-host interaction is well known, but little is known about the initial binding/colonization of the airway epithelium. Our prior studies have documented cell-signalling events that occur following bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ec058f7f2ede62a9a9cebc15947095
https://doi.org/10.1099/jmm.0.000864
https://doi.org/10.1099/jmm.0.000864
Autor:
Deanne Hebrink, Vijayalakshmi Nandakumar, Eva M. Carmona, Andrew H. Limper, Theodore J. Kottom
Publikováno v:
Cell Microbiol
Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule critical for key signaling pathways initiated through C-type lectin receptors (CLRs). Previous studies demonstrated that Pneumocystis organisms are recognized through a va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489db55a6046b49e0b44763082c4abae
https://europepmc.org/articles/PMC7755114/
https://europepmc.org/articles/PMC7755114/
Autor:
Sho Yamasaki, Paige E. Jenson, Bruce S. Klein, Marcel Wüthrich, Huafeng Wang, Theodore J. Kottom, Deanne Hebrink, Andrew H. Limper, Paige L. Marsolek
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:232-240
Pneumocystis is an important fungal pathogen that causes life-threatening pneumonia in patients with AIDS and malignancy. Lung fungal pathogens are recognized by C-type lectin receptors (CLRs), which bind specific ligands and stimulate innate immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e00a9f737c8864210cc47309da5d80d
https://doi.org/10.1165/rcmb.2016-0335oc
https://doi.org/10.1165/rcmb.2016-0335oc
Autor:
Deanne Hebrink, Jorge H. Ramirez-Prado, Andrew H. Limper, Paige E. Jenson, Theodore J. Kottom
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 56:213-222
N-acetylglucosamine (GlcNAc) serves as an essential structural sugar on the cell surface of organisms. For example, GlcNAc is a major component of bacterial peptidoglycan, it is an important building block of fungal cell walls, including a major cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e53070ddef7d1cda5cda89b70db8336
https://doi.org/10.1165/rcmb.2016-0155oc
https://doi.org/10.1165/rcmb.2016-0155oc
Publikováno v:
J Infect Dis
BackgroundPneumocystis major surface glycoprotein (Msg) is a 120-kD surface protein complex on the organism with importance in adhesion and immune recognition. In this study, we show that Msg significantly impairs tumor necrosis factor (TNF)-α secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8b63b117b1839935274d5cb4f353fb
https://pubmed.ncbi.nlm.nih.gov/32363390
https://pubmed.ncbi.nlm.nih.gov/32363390
Autor:
Tessa R. Davis, Aaron J. Johnson, Jamie Rossjohn, Mark A. Daniels, Alejandro Ferrer, Adam G. Schrum, Deanne Hebrink, Kevin D. Pavelko, Stephen E. P. Smith, Jenna M. Canfield, Katelynn M. Wilton, Peter J. Wettstein, Dietmar J. Kappes, Diana Gil, Larry R. Pease, Scott R. Burrows, James McCluskey, April M. Huseby Kelcher, Claudia Neuhauser, Zhenjun Chen, Steven C. Neier, Eva M. Carmona, Andrew H. Limper, Robert J. Stiles
Publikováno v:
Sci Immunol
During αβ T cell development, T cell antigen receptor (TCR) engagement transduces biochemical signals through a protein-protein interaction (PPI) network that dictates dichotomous cell fate decisions. It remains unclear how signal specificity is co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fad1a3e06f1347ccfdcf6b2fb62e3d
https://doi.org/10.1126/sciimmunol.aal2201
https://doi.org/10.1126/sciimmunol.aal2201
Publikováno v:
Respiratory infections.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abe5497fe7ca440f538a37f9157ba69
https://doi.org/10.1183/13993003.congress-2018.pa5462
https://doi.org/10.1183/13993003.congress-2018.pa5462
Publikováno v:
Infection and Immunity. 83:2816-2826
Inflammation is a major cause of respiratory impairment during Pneumocystis pneumonia. Studies support a significant role for cell wall β-glucans in stimulating inflammatory responses. Fungal β-glucans are comprised of d -glucose homopolymers conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2bb7d3568c73ffcc723c085d638ea5
https://doi.org/10.1128/iai.00196-15
https://doi.org/10.1128/iai.00196-15
Autor:
Theodore J. Kottom, Vijayalakshmi Nandakumar, Deanne Hebrink, Paige E. Jenson, Andrew H. Limper
We explored differential polarization of macrophages during infection using a rat model of Pneumocystis pneumonia. We observed enhanced pulmonary M1 macrophage polarization in immunosuppressed (IS) hosts, but an M2 predominant response in immunocompe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a33c80ec6a819e6272daa8addc5431
https://europepmc.org/articles/PMC5328482/
https://europepmc.org/articles/PMC5328482/