Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Deanna M Marchionini"'
Autor:
Deanna M. Marchionini, Jeh-Ping Liu, Alberto Ambesi-Impiombato, Kimberly Kerker, Kim Cirillo, Mukesh Bansal, Rich Mushlin, Daniela Brunner, Sylvie Ramboz, Mei Kwan, Kirsten Kuhlbrodt, Karsten Tillack, Finn Peters, Leena Rauhala, John Obenauer, Jonathan R. Greene, Christopher Hartl, Vinod Khetarpal, Brenda Lager, Jim Rosinski, Jeff Aaronson, Morshed Alam, Ethan Signer, Ignacio Muñoz-Sanjuán, David Howland, Scott O. Zeitlin
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
We have developed an inducible Huntington’s disease (HD) mouse model that allows temporal control of whole-body allele-specific mutant huntingtin (mHtt) expression. We asked whether moderate global lowering of mHtt (~50%) was sufficient for long-te
Externí odkaz:
https://doaj.org/article/134f08ad54bc41838bc7ff1320c3e0ea
Autor:
Shiyu Xu, Gang Li, Xin Ye, Dongsheng Chen, Zhihua Chen, Zhen Xu, Moretti Daniele, Sara Tambone, Alessandra Ceccacci, Licia Tomei, Lili Ye, Yue Yu, Amanda Solbach, Stephen M. Farmer, Erin Furr Stimming, George McAllister, Deanna M. Marchionini, Sheng Zhang
Publikováno v:
PLoS Genetics, Vol 18, Iss 7 (2022)
Perturbation of huntingtin (HTT)’s physiological function is one postulated pathogenic factor in Huntington’s disease (HD). However, little is known how HTT is regulated in vivo. In a proteomic study, we isolated a novel ~40kDa protein as a stron
Externí odkaz:
https://doaj.org/article/c7360dc9b466498b894ef2ac0e70a9a8
Autor:
Taneli Heikkinen, Timo Bragge, Juha Kuosmanen, Teija Parkkari, Sanna Gustafsson, Mei Kwan, Jose Beltran, Afshin Ghavami, Srinivasa Subramaniam, Neelam Shahani, Uri Nimrod Ramírez-Jarquín, Larry Park, Ignacio Muñoz-Sanjuán, Deanna M Marchionini
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)
Huntington's disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes is a Ras-related small GTP-binding
Externí odkaz:
https://doaj.org/article/5d08393a3e9247bea54802339f2736c8
Autor:
Alberto Bresciani, Maria Carolina Spiezia, Roberto Boggio, Cristina Cariulo, Anja Nordheim, Roberta Altobelli, Kirsten Kuhlbrodt, Celia Dominguez, Ignacio Munoz-Sanjuan, John Wityak, Valentina Fodale, Deanna M Marchionini, Andreas Weiss
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194423 (2018)
Autophagy is a cellular mechanism that can generate energy for cells or clear misfolded or aggregated proteins, and upregulating this process has been proposed as a therapeutic approach for neurodegenerative diseases. Here we describe a novel set of
Externí odkaz:
https://doaj.org/article/616beb1cabb749c9965d10a4c5518952
Autor:
Daniele Bertoglio, Jonathan Bard, Manuela Hessmann, Longbin Liu, Annette Gärtner, Stef De Lombaerde, Britta Huscher, Franziska Zajicek, Alan Miranda, Finn Peters, Frank Herrmann, Sabine Schaertl, Tamara Vasilkovska, Christopher J. Brown, Peter D. Johnson, Michael E. Prime, Matthew R. Mills, Annemie Van der Linden, Ladislav Mrzljak, Vinod Khetarpal, Yuchuan Wang, Deanna M. Marchionini, Mette Skinbjerg, Jeroen Verhaeghe, Celia Dominguez, Steven Staelens, Ignacio Munoz-Sanjuan
Publikováno v:
Science translational medicine
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT ) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract
Publikováno v:
Cell Transplantation, Vol 13 (2004)
One experimental therapy for Parkinson's disease (PD) is the transplantation of embryonic ventral mesencephalic tissue. Unfortunately, up to 95% of grafted neurons die, many via apoptosis. Activated caspases play a key role in execution of the apopto
Externí odkaz:
https://doaj.org/article/a2d0fdf93deb45a9b057da7d9e54b795
Autor:
Deanna M. Marchionini, Nathan D. Levine, Brian T. Terpstra, Katrina L. Paumier, Timothy J. Collier, Caryl E. Sortwell
Publikováno v:
Journal of Neuroscience Methods. 166:13-19
Patients with Parkinson's disease (PD) present clinically with bradykinesia, rigidity, and resting tremor (Olanow and Tatton, 1999). While pathology occurs throughout the brain in sporadic PD, these symptoms can mainly be attributed to the degenerati
Autor:
Deanna M. Marchionini, Nicholas M. Kanaan, Timothy J. Collier, Matthew F. Fleming, Caryl E. Sortwell, Susan O. McGuire
Publikováno v:
Brain Research. 1068:221-229
Parkinson's disease (PD) is a neurodegenerative disease marked by severe loss of dopamine (DA) neurons in the nigrostriatal system, which results in depletion of striatal DA. Transplantation of embryonic ventral mesencephalic (VM) DA neurons into the
Autor:
Brian F. Daley, Timothy J. Collier, Susan O. McGuire, Deanna M. Marchionini, Matthew F. Fleming, Caryl E. Sortwell, Mark R. Pitzer
Publikováno v:
Experimental Neurology. 182:435-445
The present series of experiments investigated the effects of vascular endothelial growth factor (VEGF165) on adult rat striatal cerebrovasculature and embryonic dopamine (DA) neuron allografts in a rat model of Parkinson's disease (PD). We examined
Autor:
Maria D. Camargo, Caryl E. Sortwell, Timothy J. Collier, Susan O. McGuire, Deanna M. Marchionini, Mark R. Pitzer
Publikováno v:
The Journal of Comparative Neurology. 464:172-179
One promising therapy for the treatment of Parkinson's disease is transplantation of embryonic ventral mesencephalic tissue. Unfortunately, up to 95% of grafted cells die, many via apoptosis. In this study we attempted to prevent anoikis-induced cell