Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Deanna L. Kroetz"'
Autor:
Chetan P. Kulkarni, Jia Yang, Megan L. Koleske, Giovanni Lara, Khondoker Alam, Andre Raw, Bhagwant Rege, Liang Zhao, Dongmei Lu, Lei Zhang, Lawrence X. Yu, Robert A. Lionberger, Kathleen M. Giacomini, Deanna L. Kroetz, Sook Wah Yee
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 647 (2024)
The presence of mutagenic and carcinogenic N-nitrosamine impurities in medicinal products poses a safety risk. While incorporating antioxidants in formulations is a potential mitigation strategy, concerns arise regarding their interference with drug
Externí odkaz:
https://doaj.org/article/db2f7b3198274994a190b6df5cb02c07
Autor:
Chenling Xiong, Katherina C. Chua, Tore B. Stage, Josefina Priotti, Jeffrey Kim, Anne Altman‐Merino, Daniel Chan, Krishna Saraf, Amanda Canato Ferracini, Faranak Fattahi, Deanna L. Kroetz
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 568-581 (2021)
Chemotherapy‐induced peripheral neuropathy (CIPN) is a dose‐limiting adverse event associated with treatment with paclitaxel and other chemotherapeutic agents. The prevention and treatment of CIPN are limited by a lack of understanding of the mol
Externí odkaz:
https://doaj.org/article/3a9ff7551bbf438e89d4750e512cd6e3
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 460-467 (2021)
Chemotherapy‐induced peripheral neuropathy (CIPN) is a common and dose‐limiting toxicity to widely used chemotherapeutics. Although the exact molecular mechanism of chemotherapy‐induced peripheral neuropathy remains elusive, there is consensus
Externí odkaz:
https://doaj.org/article/e48cd4b4288942deac1c2b135d72b811
Autor:
Amanda Canato Ferracini, Leisa Lopes-Aguiar, Gustavo Jacob Lourenço, Adriana Yoshida, Carmen Silva Passos Lima, Luis Otávio Sarian, Sophie Derchain, Deanna L. Kroetz, Priscila Gava Mazzola
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 720-728 (2021)
Variation in drug disposition genes might contribute to susceptibility to toxicities and interindividual differences in clinical management on chemotherapy for epithelial ovarian cancer (EOC). This study was designed to explore the association of GST
Externí odkaz:
https://doaj.org/article/ea6410ce8e9d4dd8baf266c4a1b373e7
Autor:
Sook Wah Yee, Marilyn M. Giacomini, Hong Shen, W. Griffith Humphreys, Howard Horng, William Brian, Yurong Lai, Deanna L. Kroetz, Kathleen M. Giacomini
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 4, Pp 388-399 (2019)
Understanding transporter‐mediated drug–drug interactions is an integral part of risk assessment in drug development. Recent studies support the use of hexadecanedioate (HDA), tetradecanedioate (TDA), coproporphyrin (CP)‐I, and CP‐III as clin
Externí odkaz:
https://doaj.org/article/7aec9e736d274c7e909b1eb4fcb6398c
Autor:
Zhiguo Li, Jiaxing Lin, Alexander B. Sibley, Tracy Truong, Katherina C. Chua, Yu Jiang, Janice McCarthy, Deanna L. Kroetz, Andrew Allen, Kouros Owzar
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Time- and dose-to-event phenotypes used in basic science and translational studies are commonly measured imprecisely or incompletely due to limitations of the experimental design or data collection schema. For example, drug-induce
Externí odkaz:
https://doaj.org/article/45bcb670e1ba4d39ad8ff52564b32950
Autor:
Sierk Haenisch, Yi Zhao, Aparna Chhibber, Kitti Kaiboriboon, Lynn V. Do, Silke Vogelgesang, Nicholas M. Barbaro, Brian K. Alldredge, Daniel H. Lowenstein, Ingolf Cascorbi, Deanna L. Kroetz
Publikováno v:
Neurobiology of Disease, Vol 77, Iss , Pp 127-140 (2015)
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally control the expression of their target genes via RNA interference. There is increasing evidence that expression of miRNAs is dysregulated in neuronal disorders, including epilep
Externí odkaz:
https://doaj.org/article/a5bb73dac40644289e2604a39397ca06
Autor:
Howard L. McLeod, Mark J. Ratain, Michael J. Morris, M. Eileen Dolan, Susan G. Dorsey, Michiaki Kubo, Yusuke Nakamura, Michael J. Kelley, Michael A. Carducci, John F. Mahoney, Paula N. Friedman, Deanna L. Kroetz, Ivo Shterev, Phillip G. Febbo, Eric J. Small, Cynthia L. Renn, Flora Mulkey, Stefanie D. Krens, Dorothy Watson, Lois Weisman, Cameron Lassiter, Alexander B. Sibley, Heather E. Wheeler, Yoichi Furukawa, Susan Halabi, Jai Patel, William Kevin Kelly, Chen Jiang, Claudia Wing, Sherrie Lessans, Kouros Owzar, Daniel L. Hertz
1000 SNPs with greatest statistical association with cumulative docetaxel dose at grade 3+ neuropathy in CALGB 90401 discovery GWAS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3a32f960da8ef5ef60d314598d5e4a
https://doi.org/10.1158/1078-0432.22468622
https://doi.org/10.1158/1078-0432.22468622
Autor:
Mary Eileen Dolan, Nancy J. Cox, Deanna L. Kroetz, Mark J. Ratain, Yusuke Nakamura, Lawrence N. Shulman, Clifford A. Hudis, Eric P. Winer, Hitoshi Zembutsu, Michiaki Kubo, Ivo Shterev, Dorothy Watson, Chen Jiang, Kouros Owzar, Robert Michael Baldwin, Chidiamara Njoku, Uchenna O. Njiaju, Claudia Wing, Eric R. Gamazon, Heather E. Wheeler
PDF file - 409K, SNP call plots from the CALGB 40101 patient genotyping on the Illumina 610-Quad platform for the patient/LCL overlap SNPs in genes. R is the combined SNP intensity and theta is the allelic intensity ratio.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8243f1624a07447d46d3e678bc08b749
https://doi.org/10.1158/1078-0432.22455467
https://doi.org/10.1158/1078-0432.22455467
Autor:
Mary Eileen Dolan, Nancy J. Cox, Deanna L. Kroetz, Mark J. Ratain, Yusuke Nakamura, Lawrence N. Shulman, Clifford A. Hudis, Eric P. Winer, Hitoshi Zembutsu, Michiaki Kubo, Ivo Shterev, Dorothy Watson, Chen Jiang, Kouros Owzar, Robert Michael Baldwin, Chidiamara Njoku, Uchenna O. Njiaju, Claudia Wing, Eric R. Gamazon, Heather E. Wheeler
PDF file - 1866K, The 11 overlap SNPs within genes associated with both patient paclitaxel-induced sensory peripheral neuropathy (P < 0.05) and LCL paclitaxel-induced cytotoxicity (P < 0.001). The Kaplan Meier plots show the probability of the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b562ea1ad51686a05d9c7a37c3405b1
https://doi.org/10.1158/1078-0432.22455464.v1
https://doi.org/10.1158/1078-0432.22455464.v1