Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Deanna L. Davis"'
Autor:
Avan Antia, David M. Alvarado, Qiru Zeng, Luis A. Casorla-Perez, Deanna L. Davis, Naomi M. Sonnek, Matthew A. Ciorba, Siyuan Ding
Publikováno v:
Viruses, Vol 16, Iss 4, p 634 (2024)
The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022. Studies indicate that Omicron replicates less efficiently in lung tissue compared to the an
Externí odkaz:
https://doaj.org/article/38974c74f9894c49aa5e9ae3369a7b50
Autor:
Sophia M. Sears, Tess V. Dupre, Parag P. Shah, Deanna L. Davis, Mark A. Doll, Cierra N. Sharp, Alexis A. Vega, Judit Megyesi, Levi J. Beverly, Ashley J. Snider, Lina M. Obeid, Yusuf A. Hannun, Leah J. Siskind
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100179- (2022)
Cisplatin is a commonly used chemotherapeutic for the treatment of many solid organ cancers; however, its effectiveness is limited by the development of acute kidney injury (AKI) in 30% of patients. AKI is driven by proximal tubule cell death, leadin
Externí odkaz:
https://doaj.org/article/7dba3275e68d4f6cbe26e068dfcb7af5
Autor:
Deanna L. Davis, Usha Mahawar, Victoria S. Pope, Jeremy Allegood, Carmen Sato-Bigbee, Binks W. Wattenberg
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 4, Pp 505-522 (2020)
Myelin is a unique lipid-rich membrane structure that accelerates neurotransmission and supports neuronal function. Sphingolipids are critical myelin components. Yet sphingolipid content and synthesis have not been well characterized in oligodendrocy
Externí odkaz:
https://doaj.org/article/dae4b46939ec4670b6e03c8e2ecab695
Omicron B.1.1.529 became the predominant SARS-CoV-2 variant in early 2022, causing a new wave of public anxiety. Compared to the ancestral strain, Omicron has 50 mutations, with over 30 mutations in the spike protein. These differences likely underli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b679879ea319054494459246d0cbbe
https://doi.org/10.1101/2022.04.13.487939
https://doi.org/10.1101/2022.04.13.487939
Autor:
Christopher Green, Deanna L. Davis, Sarah Spiegel, Michael Maceyka, Usha Mahawar, Clement Oyeniran, Binks W. Wattenberg, Cynthia Weigel, Jason Newton, Briana N. James
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100082-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100082-(2021)
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT. However, the roles of in
Autor:
Usha Mahawar, Jeremy C. Allegood, Victoria S. Pope, Binks W. Wattenberg, Carmen Sato-Bigbee, Deanna L. Davis
Myelin is a unique, lipid-rich membrane structure that accelerates neurotransmission and supports neuronal function. Sphingolipids are critical components of myelin. Here we examined sphingolipid synthesis during the peak period of myelination in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a87a6080f1023d8d907f31bdbb1054
https://doi.org/10.1101/2020.01.15.908277
https://doi.org/10.1101/2020.01.15.908277
Autor:
Muthukumar Kannan, Christopher D. Oltorik, Binks W. Wattenberg, Deanna L. Davis, John Suemitsu
Publikováno v:
Bio Protoc
Serine palmitoyltranferase (SPT) is a pyridoxal 5' phosphate (PLP)-dependent enzyme that catalyzes the first and rate-limiting step of de novo synthesis of sphingolipids. SPT activity is homeostatically regulated in response to increased levels of sp
Publikováno v:
The Journal of biological chemistry. 294(13)
Sphingolipids compose a lipid family critical for membrane structure as well as intra- and intercellular signaling. De novo sphingolipid biosynthesis is initiated by the enzyme serine palmitoyltransferase (SPT), which resides in the endoplasmic retic
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1867(4)
Sphingolipids are diverse lipids with essential, and occasionally opposing, functions in the cell and therefore tight control over biosynthesis is vital. Mechanisms governing this regulation are not understood. Initial steps in sphingolipid biosynthe
Publikováno v:
Advances in biological regulation. 70
Sphingolipids comprise a diverse family of lipids that perform multiple functions in both structure of cellular membranes and intra- and inter-cellular signaling. The diversity of this family is generated by an array of enzymes that produce individua