Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Deanna L, Maren"'
Autor:
Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
Publikováno v:
Journal of Medicinal Chemistry. 62:8711-8732
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a353395d3c6f7ca6dfa78c95a347dd4
https://doi.org/10.1021/acs.jmedchem.9b01234
https://doi.org/10.1021/acs.jmedchem.9b01234
Autor:
Junliang, Hao, James P, Beck, John M, Schaus, Joseph H, Krushinski, Qi, Chen, Christopher D, Beadle, Paloma, Vidal, Matthew R, Reinhard, Bruce A, Dressman, Steven M, Massey, Serge L, Boulet, Michael P, Cohen, Brian M, Watson, David, Tupper, Kevin M, Gardinier, Jason, Myers, Anette M, Johansson, Jeffery, Richardson, Daniel S, Richards, Erik J, Hembre, David M, Remick, David A, Coates, Rajni M, Bhardwaj, Benjamin A, Diseroad, David, Bender, Greg, Stephenson, Craig D, Wolfangel, Nuria, Diaz, Brian G, Getman, Xu-Shan, Wang, Beverly A, Heinz, Jeff W, Cramer, Xin, Zhou, Deanna L, Maren, Julie F, Falcone, Rebecca A, Wright, Stephen N, Mitchell, Guy, Carter, Charles R, Yang, Robert F, Bruns, Kjell A, Svensson
Publikováno v:
Journal of medicinal chemistry. 62(19)
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38771cd6f379be26a1a0dc76826df19b
https://pubmed.ncbi.nlm.nih.gov/31532644
https://pubmed.ncbi.nlm.nih.gov/31532644
Autor:
Michelle M Menezes, Jeffrey M. Witkin, Kjell A. Svensson, Brian J. Eastwood, Eyassu Chernet, Michael J. O'Neill, Julie F. Falcone, Keith A. Wafford, Hong Wang, Linda K. Thompson, John W. Ryder, Stephen N. Mitchell, Junliang Hao, John Mehnert Schaus, Robert F. Bruns, Alex J. Harper, Meghane E. Masquelin, Deanna L Maren, Xia Li, Tracey K. Murray, Charles R. Yang, Elaine Shanks, Jason Katner, Linli Zhang, Guy Carter, James P. Beck, Patrick L. Love
Publikováno v:
Neuropharmacology. 128
DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond to D1 agonists. Because of a species difference in affinity for DETQ, all rodent experiments used transgenic mice expressing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bdd0d92066c9741468043d0c8f34cb
https://pubmed.ncbi.nlm.nih.gov/29102759
https://pubmed.ncbi.nlm.nih.gov/29102759
Autor:
Junliang Hao, Wesley H. Anderson, Cohen Michael Philip, Kjell A. Svensson, Michael A. Statnick, Donald R. Gehlert, Joseph H. Krushinski, Hellman Sarah Lynne, Michelle M Menezes, Jeffrey W Cramer, Julie F. Falcone, Xushan Wang, Rebecca A. Wright, John Mehnert Schaus, Neil W. DeLapp, Reinhard Matthew Robert, S Michelle Morin, Charles R. Yang, Todd R. Wiernicki, Ilya Okun, Renee Emkey, Benjamin L. Adams, Beverly A. Heinz, Brian G. Getman, James P. Beck, Robert F. Bruns, Virginia L. Lucaites, Todd M. Suter, Deanna L Maren, David L. Nelson, Kelly L. Knopp, Borys V. Rogovoy
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407266480ca7b482e7f8dd098b6484ac
https://pubmed.ncbi.nlm.nih.gov/27811173
https://pubmed.ncbi.nlm.nih.gov/27811173