Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Deanna L, Howarth"'
Autor:
Ana M. Vacaru, Antonio Fabio Di Narzo, Deanna L. Howarth, Orkhontuya Tsedensodnom, Dru Imrie, Ayca Cinaroglu, Salma Amin, Ke Hao, Kirsten C. Sadler
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 823-835 (2014)
The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expressio
Externí odkaz:
https://doaj.org/article/f8f95406937b4c7ebfa17a14505e6e43
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1213-1226 (2013)
SUMMARY Secretory pathway dysfunction and lipid accumulation (steatosis) are the two most common responses of hepatocytes to ethanol exposure and are major factors in the pathophysiology of alcoholic liver disease (ALD). However, the mechanisms by wh
Externí odkaz:
https://doaj.org/article/756f7463a544432b9611015f93364b4d
Autor:
Deanna L Howarth, Claudia Lindtner, Ana M Vacaru, Ravi Sachidanandam, Orkhontuya Tsedensodnom, Taisa Vasilkova, Christoph Buettner, Kirsten C Sadler
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004335 (2014)
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three
Externí odkaz:
https://doaj.org/article/bc06ede5c20b4e84ae873fec8fa55a07
Autor:
Dru Imrie, Salma Amin, Ke Hao, Deanna L. Howarth, Antonio Fabio Di Narzo, Kirsten C. Sadler, Ana M. Vacaru, Ayca Cinaroglu, Orkhontuya Tsedensodnom
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 823-835 (2014)
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 823-835 (2014)
The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd408484214a470f07be48ced178bc7
https://doi.org/10.1242/dmm.014472
https://doi.org/10.1242/dmm.014472
Autor:
Ana M. Vacaru, Lindsey M. Costantini, Orkhontuya Tsedensodnom, Natalia Nieto, Kirsten C. Sadler, Erik L. Snapp, Deanna L. Howarth, Elisabetta Mormone
Publikováno v:
Alcoholism: Clinical and Experimental Research. 36:14-23
Background: Many alcoholic patients have serum protein deficiency that contributes to their systemic problems. The unfolded protein response (UPR) is induced in response to disequilibrium in the protein folding capability of the endoplasmic reticulum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd7274c574274052459afbef16c02662
https://doi.org/10.1111/j.1530-0277.2011.01602.x
https://doi.org/10.1111/j.1530-0277.2011.01602.x
Publikováno v:
Alcoholism: Clinical and Experimental Research. 35:826-829
Steatosis is the most common consequence of acute alcohol abuse, such as occurs during a drinking binge. Acute alcohol induced steatosis may predispose to more severe hepatic disease. We have developed a model of alcoholic liver disease (ALD) in zebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886a49012207f548ecb3c0cfb72e1ef6
https://doi.org/10.1111/j.1530-0277.2010.01407.x
https://doi.org/10.1111/j.1530-0277.2010.01407.x
Autor:
Sheran H.W. Law, Ni Ai, Matthew D. Krasowski, Seth W. Kullman, John T. Moore, Erin M. Kollitz, Deanna L. Howarth, Lee R. Hagey, Sean Ekins, David E. Hinton
Publikováno v:
Aquatic Toxicology. 98:245-255
The nuclear receptor farnesoid X receptor alpha (FXRalpha, NR1H4) is activated by bile acids in multiple species including mouse, rat, and human and in this study we have identified two isoforms of Fxralpha in Japanese medaka (Oryzias latipes), a sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8eb955b3f029e1dddc32a545e4a80eb
https://doi.org/10.1016/j.aquatox.2010.02.020
https://doi.org/10.1016/j.aquatox.2010.02.020
Publikováno v:
Toxicological Sciences. 102:262-277
The adaptive role of the aryl hydrocarbon receptor (Ah receptor or AHR) in protecting against disease-related conditions remains unclear in nonmammalian models, particularly teleosts. Therefore, this study focused on the potential role of AHR in resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117a886a56b230740a210901d980d558
https://doi.org/10.1093/toxsci/kfm308
https://doi.org/10.1093/toxsci/kfm308
Autor:
Christoph Buettner, Ana M. Vacaru, Taisa Vasilkova, Orkhontuya Tsedensodnom, Kirsten C. Sadler, Deanna L. Howarth, Claudia Lindtner, Ravi Sachidanandam
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 10, Iss 5, p e1004335 (2014)
PLoS Genetics, Vol 10, Iss 5, p e1004335 (2014)
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2110ff3548c16ab6887ae860fe26ef4
https://pubmed.ncbi.nlm.nih.gov/24874946
https://pubmed.ncbi.nlm.nih.gov/24874946
Publikováno v:
Zebrafish. 10(2)
Fatty liver disease in humans can progress from steatosis to hepatocellular injury, fibrosis, cirrhosis, and liver failure. We developed a series of straightforward assays to determine whether zebrafish larvae with either tunicamycin- or ethanol-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9532dbe6f951b02f2542c67eddf71b41
https://pubmed.ncbi.nlm.nih.gov/23697887
https://pubmed.ncbi.nlm.nih.gov/23697887