Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Deanna Koger"'
Autor:
David M. Holtzman, Jessica L. Restivo, Kelly R. Bales, Steven M. Paul, Robert D. Kinley, Deanna Koger, Cynthia DeLong, Jesse M. Hunter, Suizhen Lin, Patrick Sullivan, Feng Liu, John R. Cirrito, Lingzhi Zhao
Publikováno v:
Brain Research. 1467:120-132
The apolipoprotein ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and is associated with earlier age of onset. The incidence of spontaneous seizures has been reported to be increased in sporadic AD as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e4263e3745e231c8b8bc7095050c3f
https://doi.org/10.1016/j.brainres.2012.05.048
https://doi.org/10.1016/j.brainres.2012.05.048
Autor:
B. Han, Kelly R. Bales, Feng Liu, Steven M. Paul, Su Wu, Deanna Koger, John F. Ervin, Patrick Sullivan, Brian E. Mace
Publikováno v:
Neurobiology of Aging. 32:791-801
The APOE4 allele is the most common genetic determinant for Alzheimer's disease (AD) in the developed world. APOE genotype specific differences in brain apolipoprotein E protein levels have been observed in numerous studies since the discovery of APO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73771f68eefded4fc0ce2aed04e42022
https://doi.org/10.1016/j.neurobiolaging.2009.05.011
https://doi.org/10.1016/j.neurobiolaging.2009.05.011
Autor:
Cynthia DeLong, Steven M. Paul, Su Wu, Kelly R. Bales, Patrick Sullivan, Suizhen Lin, Deanna Koger, Feng Liu, Jeffrey C. Hansen
Publikováno v:
The Journal of Neuroscience. 29:6771-6779
To investigate the role of human apolipoprotein E (apoE) on Aβ depositionin vivo, we crossed PDAPP mice lacking mouseApoeto targeted replacement mice expressing human apoE (PDAPP/TRE2, PDAPP/TRE3, or PDAPP/TRE4). We then measured the levels of apoE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b894826226fafc3e04fad6cd82e12b8b
https://doi.org/10.1523/jneurosci.0887-09.2009
https://doi.org/10.1523/jneurosci.0887-09.2009
Autor:
Valentina Gelfanova, Jesse M. Hunter, Kelly R. Bales, Steven M. Paul, Suizhen Lin, Lingzhi Zhao, Feng Liu, John E. Hale, Deanna Koger, Cynthia DeLong
Publikováno v:
The Journal of Neuroscience. 29:3603-3612
Recent studies suggest that bone marrow-derived macrophages can effectively reduce β-amyloid (Aβ) deposition in brain. To further elucidate the mechanisms by which macrophages degrade Aβ, we cultured murine macrophages on top of Aβ plaque-bearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad0f060d8638c2eac91792079bca68d
https://doi.org/10.1523/jneurosci.5302-08.2009
https://doi.org/10.1523/jneurosci.5302-08.2009
Publikováno v:
Drug Development Research.
Recently there is increased regulatory interest in the assessment of physical dependence and withdrawal as part of the safety assessment for novel therapeutic entities. Choosing appropriate and sensitive parameters to detect withdrawal syndromes, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055bde7b672643ab48479bc7f887b2f5
https://doi.org/10.1002/ddr.21168
https://doi.org/10.1002/ddr.21168
Publikováno v:
Drug development research. 75(3)
Recently there is increased regulatory interest in the assessment of physical dependence and withdrawal as part of the safety assessment for novel therapeutic entities. Choosing appropriate and sensitive parameters to detect withdrawal syndromes, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0aa7546b05e7aeb5261bcbf79b427171
https://pubmed.ncbi.nlm.nih.gov/24648280
https://pubmed.ncbi.nlm.nih.gov/24648280
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d5b739cb53bf5e9cbc8d9ce3419b49
https://doi.org/10.1016/j.jalz.2006.05.378
https://doi.org/10.1016/j.jalz.2006.05.378
Autor:
Kumiko Takeuchi, Todd J. Kohn, Nicholas A. Honigschmidt, Vincent P. Rocco, Patrick G. Spinazze, Susan K. Hemrick-Luecke, Linda K. Thompson, David C. Evans, Kurt Rasmussen, Deanna Koger, David Lodge, Laura J. Martin, Janice Shaw, Penny G. Threlkeld, David T. Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61281b6574f3b8c2cceccbc47e8fd960
https://pubmed.ncbi.nlm.nih.gov/16298130
https://pubmed.ncbi.nlm.nih.gov/16298130
Autor:
Steven M. Paul, Michail A. Esterman, Jeffrey C. Hanson, Xin Wu, Kelly R. Bales, Seema Malkani, Milla Koistinaho, Suizhen Lin, Feng Liu, Richard E. Higgs, Deanna Koger
Publikováno v:
Nature medicine. 10(7)
We have previously shown that apolipoprotein E (Apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of APOE markedly affects the deposition of amyloid-beta peptides (Abeta) in a mouse model of Alzheimer disease. Gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16171983c8899a90a05640571d782ea2
https://pubmed.ncbi.nlm.nih.gov/15195085
https://pubmed.ncbi.nlm.nih.gov/15195085
Autor:
Su Wu, Cindy A. DeLong, J. Dorocke, Ronald Demattos, U. Kuchibhotla, V. Wroblewski, K.R. Bales, Margaret M. Racke, J. Lu, Deanna Koger
Publikováno v:
Neurobiology of Aging. 25:S587
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe89378437a47890b7fc5ec6389975c
https://doi.org/10.1016/s0197-4580(04)81953-5
https://doi.org/10.1016/s0197-4580(04)81953-5