Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Deanna A, Kulpa"'
Autor:
Cristina Ceriani, Brianne Beisner, Maria Crane, Joyce Cohen, Ian N. Moore, Deanna A. Kulpa, Beatrice H. Hahn, Guido Silvestri
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Sooty mangabeys (SMs) are natural hosts of simian immunodeficiency virus (SIV) and do not progress to AIDS despite high viral replication. The main factors involved in the benign nature of this infection are (i) low level of immune activatio
Externí odkaz:
https://doaj.org/article/e1623464d86a447395a1dd30588c7928
Autor:
Yury V. Kuzmichev, Carol Lackman-Smith, Sonia Bakkour, Ann Wiegand, Michael J. Bale, Andrew Musick, Wendy Bernstein, Naomi Aronson, Julie Ake, Sodsai Tovanabutra, Mars Stone, Roger G. Ptak, Mary F. Kearney, Michael P. Busch, Elizabeth R. Wonderlich, Deanna A. Kulpa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The advent of combined antiretroviral therapy (cART) has been instrumental in controlling HIV-1 replication and transmission and decreasing associated morbidity and mortality. However, cART alone is not able to cure HIV-1 due to the presence
Externí odkaz:
https://doaj.org/article/545480fa87244f56b8e17d09e2796b5a
Autor:
Samuel Druzak, Elizabeth Iffrig, Blaine R. Roberts, Tiantian Zhang, Kirby S. Fibben, Yumiko Sakurai, Hans P. Verkerke, Christina A. Rostad, Ann Chahroudi, Frank Schneider, Andrew Kam Ho Wong, Anne M. Roberts, Joshua D. Chandler, Susan O. Kim, Mario Mosunjac, Marina Mosunjac, Rachel Geller, Igor Albizua, Sean R. Stowell, Connie M. Arthur, Evan J. Anderson, Anna A. Ivanova, Jun Ahn, Xueyun Liu, Kristal Maner-Smith, Thomas Bowen, Mirko Paiardini, Steve E. Bosinger, John D. Roback, Deanna A. Kulpa, Guido Silvestri, Wilbur A. Lam, Eric A. Ortlund, Cheryl L. Maier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
In this work, authors take a multiomics and microfluidics-based approach to elucidate the mechanism of endothelial damage in critical illness associated with SARS-CoV-2.
Externí odkaz:
https://doaj.org/article/f453c7377ff248be8d16d63d8c87445a
Autor:
Monica D. Reece, Colin Song, Sarah C. Hancock, Susan Pereira Ribeiro, Deanna A. Kulpa, Christina Gavegnano
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
B cell lymphoma 2 (BCL-2) family proteins are involved in the mitochondrial apoptotic pathway and are key modulators of cellular lifespan, which is dysregulated during human immunodeficiency virus type 1 (HIV-1) and other viral infections, thereby in
Externí odkaz:
https://doaj.org/article/5e1637a788c84da5b6d3a5d16d91af4f
Autor:
Zachary Strongin, Timothy N Hoang, Gregory K Tharp, Andrew R Rahmberg, Justin L Harper, Kevin Nguyen, Lavinia Franchitti, Barbara Cervasi, Max Lee, Zhan Zhang, Eli A Boritz, Guido Silvestri, Vincent C Marconi, Steven E Bosinger, Jason M Brenchley, Deanna A Kulpa, Mirko Paiardini
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010723 (2022)
Despite the advent of effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) continues to pose major challenges, with extensive pathogenesis during acute and chronic infection prior to ART initiation and continued persistence in a
Externí odkaz:
https://doaj.org/article/0d173f19d60843dc8264274e0962880c
Autor:
Justin Harper, Susan P. Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Luca Micci, Maria Pino, Barbara Cervasi, Gopalan Raghunathan, Eric Rimmer, Gulesi Ayanoglu, Guoxin Wu, Neeta Shenvi, Richard J.O. Barnard, Gregory Q. Del Prete, Kathleen Busman-Sahay, Guido Silvestri, Deanna A. Kulpa, Steven E. Bosinger, Kirk A. Easley, Bonnie J. Howell, Dan Gorman, Daria J. Hazuda, Jacob D. Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)
Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV-infected macaques, levels of IL-10 in plasma and lymph nodes (LNs) wer
Externí odkaz:
https://doaj.org/article/3c551d2d1a814a3d84819bbd3a685652
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100924- (2021)
Summary: Here, we describe a protocol for cell-based detection of autoantibodies from human plasma and serum samples using a standard flow cytometer. The protocol allows detection of autoantibodies against a wide array of extracellular antigens. Anti
Externí odkaz:
https://doaj.org/article/5fce61c6d1f641dcac14af79471363e5
Autor:
Andrew Kam Ho Wong, Isaac Woodhouse, Frank Schneider, Deanna A. Kulpa, Guido Silvestri, Cheryl L. Maier
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 6, Pp 100321- (2021)
Summary: The pathogenesis of severe coronavirus disease 2019 (COVID-19) remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonst
Externí odkaz:
https://doaj.org/article/743f4b2bc42b43afa89942e1a244d4ab
Autor:
Maura Statzu, Wang Jin, Emily J. Fray, Andrew Kam Ho Wong, Mithra R. Kumar, Elizabeth Ferrer, Steffen S. Docken, Mykola Pinkevych, Julia B. McBrien, Christine M. Fennessey, Brandon F. Keele, Shan Liang, Justin L. Harper, Simona Mutascio, Lavinia Franchitti, Hong Wang, Davide Cicetti, Steven E. Bosinger, Diane G. Carnathan, Thomas H. Vanderford, David M. Margolis, J. Victor Garcia-Martinez, Ann Chahroudi, Mirko Paiardini, Janet Siliciano, Miles P. Davenport, Deanna A. Kulpa, Robert S. Siliciano, Guido Silvestri
Publikováno v:
Nature Microbiology. 8:299-308
Persistence of the human immunodeficiency virus type-1 (HIV-1) latent reservoir in infected individuals remains a problem despite fully suppressive antiretroviral therapy (ART). While reservoir formation begins during acute infection, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db10d5604fd58f1605a3ccd68b90084d
https://doi.org/10.1038/s41564-022-01311-9
https://doi.org/10.1038/s41564-022-01311-9
Autor:
Michelle Zanoni, David Palesch, Claudia Pinacchio, Maura Statzu, Gregory K Tharp, Mirko Paiardini, Ann Chahroudi, Steven E Bosinger, Jack Yoon, Bryan Cox, Guido Silvestri, Deanna A Kulpa
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008821 (2020)
MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication via the recognition and killing of productively infected CD4+ T cells. Several studies i
Externí odkaz:
https://doaj.org/article/88b19171596b48d391661c9c882ff045