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of 235
pro vyhledávání: '"Deane, CM"'
Accelerating the discovery of novel and more effective therapeutics is an important pharmaceutical problem in which deep learning is playing an increasingly significant role. However, real-world drug discovery tasks are often characterized by a scarc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::844232ac487fbfa0e8f96ef091432dc3
https://ora.ox.ac.uk/objects/uuid:733eaa50-f835-4ead-adc4-9e76a4c79c46
https://ora.ox.ac.uk/objects/uuid:733eaa50-f835-4ead-adc4-9e76a4c79c46
Autor:
Ghraichy, M, Galson, JD, Kovaltsuk, A, von Niederhäusern, V, Pachlopnik Schmid, J, Recher, M, Jauch, AJ, Miho, E, Kelly, DF, Deane, CM, Trück, J
Publikováno v:
Frontiers in Immunology
B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e3b8567288b7613e85f46a5f6d4b9668
https://www.zora.uzh.ch/id/eprint/193090/
https://www.zora.uzh.ch/id/eprint/193090/
Publikováno v:
mAbs
Complementarity-determining regions (CDRs) are antibody loops that make up the antigen binding site. Here, we show that all CDR types have structurally similar loops of different lengths. Based on these findings, we created length-independent canonic
Motivated by a cutting edge problem related to the shape of α−helices in proteins, we formulate a parametric statistical model, which incorporates the cylindrical nature of the helix. Our focus is to detect a “kink”, which is a drastic change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::89cf20f13fbc3bfdfdac6458cc39fb30
https://ora.ox.ac.uk/objects/uuid:4fbd1140-bebd-457b-b043-16bd027cd114
https://ora.ox.ac.uk/objects/uuid:4fbd1140-bebd-457b-b043-16bd027cd114
Antibodies and T-cell receptors are important proteins of the immune system that share similar structures. Both contain variable and constant regions. Insight into the dynamics of their binding can be provided by computational simulations. For these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6c750ff4cee1fea7029c3567c430aea7
https://doi.org/10.1021/acs.jctc.7b00080
https://doi.org/10.1021/acs.jctc.7b00080
Autor:
Parks, T, Mirabel, MM, Kado, J, Auckland, K, Nowak, J, Rautanen, A, Mentzer, AJ, Marijon, E, Jouven, X, Perman, ML, Cua, T, Kauwe, JK, Allen, JB, Taylor, H, Robson, KJ, Deane, CM, Steer, AC, Hill, AVS
The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::722dc4aaa3df24dcdfbbfb6c0da0ae33
http://hdl.handle.net/10044/1/99684
http://hdl.handle.net/10044/1/99684
Fragment-based modeling of membrane protein loops: successes, failures, and prospects for the future
Membrane proteins (MPs) have become a major focus in structure prediction, due to their medical importance. There is, however, a lack of fast and reliable methods that specialize in the modeling of MP loops. Often methods designed for soluble protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0ba1e85a6bb86c914df48c6537d14430
https://doi.org/10.1002/prot.24299
https://doi.org/10.1002/prot.24299
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