Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues.

Autor: Lucile E Wrenshall, Suzanne E Clabaugh, David R Cool, Prakash Arumugam, William C Grunwald, Deandra R Smith, Gino C Liu, John D Miller

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102191 (2014)

Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant.

Externí odkaz: https://doaj.org/article/dbad86626563441da1df31c3ec58e59c

Human Alcohol-Microbiota Mice have Increased Susceptibility to Bacterial Pneumonia

Autor: Kelly C. Cunningham, Deandra R. Smith, Daniel N. Villageliú, Christi M. Ellis, Amanda E. Ramer-Tait, Jeffrey D. Price, Todd A. Wyatt, Daren L. Knoell, Mystera M. Samuelson, Patricia E. Molina, David A. Welsh, Derrick R. Samuelson

Publikováno v: Cells, Vol 12, Iss 18, p 2267 (2023)

Preclinical studies have shown that chronic alcohol abuse leads to alterations in the gastrointestinal microbiota that are associated with behavior changes, physiological alterations, and immunological effects. However, such studies have been limited

Externí odkaz: https://doaj.org/article/a8b96d662ac14c31a8d5d2a677a403f0

Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia

Autor: Derrick R. Samuelson, Daren L. Knoell, Todd A. Wyatt, Kristina L. Bailey, Sannette C. Hall, Shetty Ravi Dyavar, Deandra R. Smith

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 207(5)

Zinc (Zn) is required for proper immune function and host defense. Zn homeostasis is tightly regulated by Zn transporters that coordinate biological processes through Zn mobilization. Zn deficiency is associated with increased susceptibility to bacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e0a7b5c2fa2a15baf3ab3340935dd7
https://pubmed.ncbi.nlm.nih.gov/34380651

ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia

Autor: Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1022
International Journal of Molecular Sciences, Vol 23, Iss 1022, p 1022 (2022)

Pneumococcal pneumonia is a leading cause of morbidity and mortality worldwide. An increased susceptibility is due, in part, to compromised immune function. Zinc is required for proper immune function, and an insufficient dietary intake increases the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551d4949bcabd05d52ba858f8a42cee
https://doi.org/10.3390/ijms23031022

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

Autor: Richard G. MacDonald, Diane L. Costanzo-Garvey, Beth K. Neilsen, Lili Guo, Robert E. Lewis, Deandra R. Smith

Publikováno v: Molecular Metabolism, Vol 6, Iss 2, Pp 194-205 (2017)
Molecular Metabolism

Objective Kinase Suppressor of Ras 2 (KSR2) is a molecular scaffold coordinating Raf/MEK/ERK signaling that is expressed at high levels in the brain. KSR2 disruption in humans and mice causes obesity and insulin resistance. Understanding the anatomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4722fa7bb5f431d1f43f81bfc28f2ee5
http://www.sciencedirect.com/science/article/pii/S221287781630357X