Natural killer cell effector function is critical for host defense against alcohol-associated bacterial pneumonia

Autor: Daniel N. Villageliu, Kelly C. Cunningham, Deandra R. Smith, Daren L. Knoell, Mason Mandolfo, Todd A. Wyatt, Derrick R. Samuelson

Publikováno v: npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)

Abstract Alcohol use is an independent risk factor for the development of bacterial pneumonia due, in part, to impaired mucus-facilitated clearance, macrophage phagocytosis, and recruitment of neutrophils. Alcohol consumption is also known to reduce

Externí odkaz: https://doaj.org/article/b24db32e6ef64bb984d11f7fc9878577

Human Alcohol-Microbiota Mice have Increased Susceptibility to Bacterial Pneumonia

Autor: Kelly C. Cunningham, Deandra R. Smith, Daniel N. Villageliú, Christi M. Ellis, Amanda E. Ramer-Tait, Jeffrey D. Price, Todd A. Wyatt, Daren L. Knoell, Mystera M. Samuelson, Patricia E. Molina, David A. Welsh, Derrick R. Samuelson

Publikováno v: Cells, Vol 12, Iss 18, p 2267 (2023)

Preclinical studies have shown that chronic alcohol abuse leads to alterations in the gastrointestinal microbiota that are associated with behavior changes, physiological alterations, and immunological effects. However, such studies have been limited

Externí odkaz: https://doaj.org/article/a8b96d662ac14c31a8d5d2a677a403f0

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

Autor: Lili Guo, Diane L. Costanzo-Garvey, Deandra R. Smith, Beth K. Neilsen, Richard G. MacDonald, Robert E. Lewis

Publikováno v: Molecular Metabolism, Vol 6, Iss 2, Pp 194-205 (2017)

Objective: Kinase Suppressor of Ras 2 (KSR2) is a molecular scaffold coordinating Raf/MEK/ERK signaling that is expressed at high levels in the brain. KSR2 disruption in humans and mice causes obesity and insulin resistance. Understanding the anatomi

Externí odkaz: https://doaj.org/article/c0b2cb4e836940ab93874e9307b17ffd

Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia

Autor: Derrick R. Samuelson, Daren L. Knoell, Todd A. Wyatt, Kristina L. Bailey, Sannette C. Hall, Shetty Ravi Dyavar, Deandra R. Smith

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 207(5)

Zinc (Zn) is required for proper immune function and host defense. Zn homeostasis is tightly regulated by Zn transporters that coordinate biological processes through Zn mobilization. Zn deficiency is associated with increased susceptibility to bacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e0a7b5c2fa2a15baf3ab3340935dd7
https://pubmed.ncbi.nlm.nih.gov/34380651

ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia

Autor: Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1022
International Journal of Molecular Sciences, Vol 23, Iss 1022, p 1022 (2022)

Pneumococcal pneumonia is a leading cause of morbidity and mortality worldwide. An increased susceptibility is due, in part, to compromised immune function. Zinc is required for proper immune function, and an insufficient dietary intake increases the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551d4949bcabd05d52ba858f8a42cee
https://doi.org/10.3390/ijms23031022