Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

Autor: Michael J. Breslin, Samuel L. Graham, Scott D. Mosser, Deana Aa, Rands E, Oliff Allen I, S J deSolms, Nancy E. Kohl, David L. Pompliano, E A Giuliani

Publikováno v: Journal of Medicinal Chemistry. 37:725-732

Inhibitors of Ras farnesyl-protein transferase are described. These are reduced pseudopeptides related to the C-terminal tetrapeptide of the Ras protein that signals farnesylation. Deletion of the carbonyl groups between the first two residues of the

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https://doi.org/10.1021/jm00032a004

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Pseudodipeptide inhibitors of protein farnesyltransferase.

Autor: deSolms SJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA., Deana AA, Giuliani EA, Graham SL, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Scholz TH, et. al.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1995 Sep 29; Vol. 38 (20), pp. 3967-71.

2-(Aminomethyl)phenols, a new class of saluretic agents. 4. Effects of oxygen and/or nitrogen substitution.

Autor: Stokker GE, Deana AA, deSolms SJ, Schultz EM, Smith RL, Cragoe EJ Jr, Baer JE, Russo HF, Watson LS

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1982 Jun; Vol. 25 (6), pp. 735-42.

2-(Aminomethyl)phenols, a new class of saluretic agents. 1. Effects of nuclear substitution.

Autor: Stokker GE, Deana AA, deSolms SJ, Schultz EM, Smith RL, Cragoe EJ Jr, Baer JE, Ludden CT, Russo HF, Scriabine A, Sweet CS, Watson LS

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1980 Dec; Vol. 23 (12), pp. 1414-27.