Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Dean Y Maeda"'
1
Akademický článek
Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity
Autor: Jeffrey Schlom, Claudia Palena, Kristen Fousek, Zhen Su, Duane H Hamilton, Hanne Lind, Lucas A Horn, Jeffrey Riskin, Heidi A Hempel, Kristen K McCampbell, Dean Y Maeda, John A Zebala
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Despite the success of immune checkpoint blockade therapy in the treatment of certain cancer types, only a small percentage of patients with solid malignancies achieve a durable response. Consequently, there is a need to develop novel appr
Externí odkaz: https://doaj.org/article/13511483f12b409eb6e9c8522f26161d
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2
Akademický článek
Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models
Autor: Lucas A. Horn, Hanne Lind, Kristen Fousek, Haiyan Qin, Nika Rajabian, Shantel Angstadt, Nicole Hsiao-Sanchez, Miriam M. Medina-Enriquez, Marcus D. Kelly, Clint T. Allen, Sarah M. Hammoudeh, Roberto Weigert, Dean Y. Maeda, John A. Zebala, Claudia Palena
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background Relapsed head and neck squamous cell carcinoma (HNSCC) unrelated to HPV infection carries a poor prognosis. Novel approaches are needed to improve the clinical outcome and prolong survival in this patient population which has poor
Externí odkaz: https://doaj.org/article/66927b8d4cfe4aeca811e4aff6bc75e1
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3
Akademický článek
Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist
Autor: John A. Zebala, Aaron D. Schuler, Stuart J. Kahn, Dean Y. Maeda
Publikováno v: Frontiers in Pharmacology, Vol 10 (2020)
Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares r
Externí odkaz: https://doaj.org/article/02111778d07a4ee8a972583f7ab1f827
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