Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dean Wilkie"'
Autor:
Bradley E. Enerson, Todd Wisialowski, Steven W. Kumpf, Dean Wilkie, Robert E. Chapin, Michael P. Lawton, Petra H. Koza-Taylor, Christopher Houle, Mark Gosink, Scott Davenport
Publikováno v:
Toxicological Sciences. 159:42-49
Drug-induced vascular injury (DIVI) in preclinical studies can delay, if not terminate, a drug development program. Clinical detection of DIVI can be very difficult as there are no definitive biomarkers known to reliably detect this disorder in all i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0348f632c6a0322f8faf748fc87c59fd
https://doi.org/10.1093/toxsci/kfx113
https://doi.org/10.1093/toxsci/kfx113
Autor:
Andrea Haegebarth, William J. Scott, Claudia Schneider, Dean Wilkie, Scott Wilhelm, Paul R. Fracasso, Martin F. Hentemann, Cathy O. Bull, Dominik Mumberg, Ningshu Liu, Bruce R. Rowley, Karl Ziegelbauer, Christoph Schatz
Publikováno v:
Molecular Cancer Therapeutics. 12:2319-2330
Because of the complexity derived from the existence of various phosphoinositide 3-kinase (PI3K) isoforms and their differential roles in cancers, development of PI3K inhibitors with differential pharmacologic and pharmacokinetic profiles would allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1baba66783689d91aa015e38c9b206e
https://doi.org/10.1158/1535-7163.mct-12-0993-t
https://doi.org/10.1158/1535-7163.mct-12-0993-t
Autor:
Dean Wilkie, Chris S. Bollinger, Nandini Kishore, Peter T. Symanowicz, Martin Hegen, Richard D. Head, Fernando A. Happa, Zaher A. Radi, Zachary S. Stewart, Sheri L. Bonar, Jeremy W. Wellen, Yutian Zhan, Janice M. Thompson, Timothy P. LaBranche, Michael I. Jesson, Prashant N. Bansal, Steven Bailey, Debra M. Meyer, Gabriel Mbalaviele, Julia A. Guzova, Chad E. Storer
Publikováno v:
Arthritis & Rheumatism. 64:3531-3542
Objective The mechanistic link between Janus kinase (JAK) signaling and structural damage to arthritic joints in rheumatoid arthritis (RA) is poorly understood. This study was undertaken to investigate how selective inhibition of JAK with tofacitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9ae849dbd56f0e81d8c0d499727b29
https://doi.org/10.1002/art.34649
https://doi.org/10.1002/art.34649
Autor:
Robin Cheiken, Soo Chin, Oana Petrenciuc, Dean Wilkie, Angela McNabola, Mark Agulnik, Christine Elser, Eric Winquist, Gregory R. Pond, Peggy Francis, Lillian L. Siu, James Elting, Eric Chen
Publikováno v:
Journal of Clinical Oncology. 25:3766-3773
Purpose To determine the efficacy and safety of single-agent sorafenib in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN) and nasopharyngeal carcinoma (NPC). Patients and Methods In this single-arm phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd0aafb5d7ba8b30beb1b494db0745d
https://doi.org/10.1200/jco.2006.10.2871
https://doi.org/10.1200/jco.2006.10.2871
Publikováno v:
Arthritis Research & Therapy
Introduction Osteoarthritis (OA) is a leading cause of disability, but despite the high unmet clinical need and extensive research seeking dependable therapeutic interventions, no proven disease-modifying treatment for OA is currently available. Due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2895c02e6d6e50bae31a25281ab24e0
http://europepmc.org/articles/PMC4635572
http://europepmc.org/articles/PMC4635572
Publikováno v:
Journal of Translational Medicine
Background To acquire the most meaningful understanding of human arthritis, it is essential to select the disease model and methodology translatable to human conditions. The primary objective of this study was to evaluate a number of analytic techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6151332b4baa4d7f6fd875e5b824c2c5
https://doi.org/10.1186/s12967-015-0641-7
https://doi.org/10.1186/s12967-015-0641-7
Autor:
Jalila Adnane, Yong S. Chang, Scott Wilhelm, Arris J. Henderson, Elizabeth Bortolon, Mark Lynch, Joan Levy, Dahai Xue, Charles Chen, Ian C. A. Taylor, Marina Ichetovkin, Dean Wilkie, Angela McNabola, Christopher A. Carter, Pamela A. Trail
Publikováno v:
Cancer Chemotherapy and Pharmacology. 59:561-574
New research findings have revealed a key role for vascular endothelial growth factor (VEGF) in the stimulation of angiogenesis in clear cell renal carcinoma (RCC) which is a highly vascularized and treatment-resistant tumor. Sorafenib (BAY 43-9006,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e983d828733645a8789daff5a44a0f7
https://doi.org/10.1007/s00280-006-0393-4
https://doi.org/10.1007/s00280-006-0393-4
Autor:
Bernd Riedl, Dean Wilkie, Patrick Vincent, Angela McNabola, Jaleel Shujath, Hong Rong, Andrei Voznesensky, Christopher A. Carter, Li Liu, Mark McHugh, Ian W. Taylor, Rich Gedrich, Charles Chen, LiYa Tang, Deepa Eveleigh, Susan Gawlak, Scott Wilhelm, Pamela A. Trail, Mark Lynch, Leonard Post, Gideon Bollag, Yichen Cao, Daniel Auclair, Lila Adnane, Bruce Rowley, Xiaomei Zhang
Publikováno v:
Cancer Research. 64:7099-7109
The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. The novel bi-aryl urea BAY 43-9006 is a potent inhibitor of Raf-1, a member of the RAF/MEK/ERK signaling pathway. Additional characterization showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b441c5007666c435b7d2f5e6a801cd57
https://doi.org/10.1158/0008-5472.can-04-1443
https://doi.org/10.1158/0008-5472.can-04-1443
Autor:
Terri A. Swanson, Walter G Roberts, Theresa Tuthill, Cedo M. Bagi, James Christensen, Dean Wilkie, Darrel P Cohen, Catharine J. Andresen
Publikováno v:
Cancer biologytherapy. 8(9)
Experimental design To investigate the antitumor effect of sunitinib and FAK/Pyk2 tyrosine kinase inhibitor (PF-562,271)combination therapy in vivo, utilizing human hepatocellular carcinoma (HCC) cells Huh7.5. Nude rats were inoculated subcutaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d10b2af57410575b26bff6063712d46
https://pubmed.ncbi.nlm.nih.gov/19458500
https://pubmed.ncbi.nlm.nih.gov/19458500
Autor:
Christopher A. Carter, Xiaomei Zhang, Dean Wilkie, Angela McNabola, Li Liu, Mark Lynch, Yichen Cao, Scott Wilhelm, Charles Chen
Publikováno v:
Cancer research. 66(24)
Angiogenesis and signaling through the RAF/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important roles in the development of hepatocellular carcinomas (HCC). Sorafenib (BAY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d7f1276c363e86486237b92b251669
https://pubmed.ncbi.nlm.nih.gov/17178882
https://pubmed.ncbi.nlm.nih.gov/17178882