Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Dean W. Felsher"'
Autor:
Anja Deutzmann, Delaney K. Sullivan, Renumathy Dhanasekaran, Wei Li, Xinyu Chen, Ling Tong, Wadie D. Mahauad-Fernandez, John Bell, Adriane Mosley, Angela N. Koehler, Yulin Li, Dean W. Felsher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYC high but not MYC low cells by a CR
Externí odkaz:
https://doaj.org/article/5d5960aaff2349adbf61a3465136928e
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundThe cyclic adenosine monophosphate/phosphodiesterase 4 (cAMP/PDE4) pathway is involved in inflammation and immune regulation; however, the effect of cAMP/PDE4 on immune infiltration and immune evasion in lung adenocarcinoma (LUAD) remains u
Externí odkaz:
https://doaj.org/article/fb1fd8e94d494044900be7995e798f7b
Autor:
Sharon S. Hori, Ling Tong, Srividya Swaminathan, Mariola Liebersbach, Jingjing Wang, Sanjiv S. Gambhir, Dean W. Felsher
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The targeted inactivation of individual oncogenes can elicit regression of cancers through a phenomenon called oncogene addiction. Oncogene addiction is mediated by cell-autonomous and immune-dependent mechanisms. Therapeutic resistance to o
Externí odkaz:
https://doaj.org/article/5eaa4c551c6b436ebaa97bfaaabc2d0e
Autor:
Renumathy Dhanasekaran, Jangho Park, Alekesey Yevtodiyenko, David I. Bellovin, Stacey J. Adam, Anand Rajan KD, Meital Gabay, Hanan Fernando, Julia Arzeno, Vinodhini Arjunan, Sergei Gryanzov, Dean W. Felsher
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 850-859 (2020)
The MYC oncogene is dysregulated in most human cancers and hence is an attractive target for cancer therapy. We and others have shown experimentally in conditional transgenic mouse models that suppression of the MYC oncogene is sufficient to induce r
Externí odkaz:
https://doaj.org/article/bc11f22a57154389bb3c27396566ada8
Autor:
Srividya Swaminathan, Aida S. Hansen, Line D. Heftdal, Renumathy Dhanasekaran, Anja Deutzmann, Wadie D. M. Fernandez, Daniel F. Liefwalker, Crista Horton, Adriane Mosley, Mariola Liebersbach, Holden T. Maecker, Dean W. Felsher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natur
Externí odkaz:
https://doaj.org/article/e934ba6da0f2436b96b15ce1e0b4094b
Autor:
Ian Lai, Srividya Swaminathan, Virginie Baylot, Adriane Mosley, Renumathy Dhanasekaran, Meital Gabay, Dean W. Felsher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-11 (2018)
Abstract Interleukin-12 (IL-12) is a promising candidate for cancer immunotherapy because of its ability to activate a number of host immune subsets that recognize and destroy cancer cells. We found that human hepatocellular carcinoma (HCC) patients
Externí odkaz:
https://doaj.org/article/ba363b32d30a4a5a91fb431cba40596a
Autor:
Sean T. Bailey, Aleisha M. Smith, Jordan Kardos, Sara E. Wobker, Harper L. Wilson, Bhavani Krishnan, Ryoichi Saito, Hyo Jin Lee, Jing Zhang, Samuel C. Eaton, Lindsay A. Williams, Ujjawal Manocha, Dorien J. Peters, Xinchao Pan, Thomas J. Carroll, Dean W. Felsher, Vonn Walter, Qing Zhang, Joel S. Parker, Jen Jen Yeh, Richard A. Moffitt, Janet Y. Leung, William Y. Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl a
Externí odkaz:
https://doaj.org/article/0f0c33aaa830403a92bded52b464aea5
Autor:
Chi-Hwa Wu, Debashis Sahoo, Constadina Arvanitis, Nicole Bradon, David L. Dill, Dean W. Felsher
Publikováno v:
PLoS Genetics, Vol 9, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/18288fb4522843d59b64b6d545484b0f
Autor:
Delaney K. Sullivan, Anja Deutzmann, Josiah Yarbrough, Maya S. Krishnan, Arvin M. Gouw, David I. Bellovin, Stacey J. Adam, Daniel F. Liefwalker, Renumathy Dhanasekaran, Dean W. Felsher
Publikováno v:
Oncogene. 41:4960-4970
Autor:
Yao-Yu Gong, Hongguang Shao, Yu Li, Patricia Brafford, Zachary E. Stine, Jing Sun, Dean W. Felsher, Jordan S. Orange, Steven M. Albelda, Chi V. Dang
Publikováno v:
Cancer Research Communications. 2:842-856
Adoptive cell transfer (ACT) immunotherapy has remarkable efficacy against some hematologic malignancies. However, its efficacy in solid tumors is limited by the adverse tumor microenvironment (TME) conditions, most notably that acidity inhibits T an