Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dean R. Haubrich"'
Publikováno v:
Life Sciences. 20:1465-1478
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943e72e555f412af4964a2680a85efb1
https://doi.org/10.1016/0024-3205(77)90437-4
https://doi.org/10.1016/0024-3205(77)90437-4
Autor:
R A Ferrari, E. J. Alexander, Daniel Luttinger, Mark H. Perrone, Dean R. Haubrich, Denis M. Bailey, M. J. Castaldi, Mark P. Wentland
Publikováno v:
Journal of Medicinal Chemistry. 30:1482-1489
A unique combination of alpha 2-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of 2-substituted 4,5-dihydro-1H-imidazole derivatives. This combination of blocking activities has provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4ef70b38752bd43e5f60a3da88a730
https://doi.org/10.1021/jm00391a034
https://doi.org/10.1021/jm00391a034
Publikováno v:
European Journal of Pharmacology. 33:389-393
Spontaneously hypertensive rats (SHR) were compared with normotensive Wistar rats for their sensitivity to tonic extensor seizures. SHR were more sensitive to seizures and did not respond to the anticonvulsant effects of L-DOPA. SHR had a slower turn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c61dd0cdf1ecfc9392a07a461e8b86
https://doi.org/10.1016/0014-2999(75)90184-3
https://doi.org/10.1016/0014-2999(75)90184-3
Autor:
Paulina F.L. Wang, Dean R. Haubrich
Publikováno v:
Brain Research. 131:158-161
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee27230485050cc2dcaeb81069a95491
https://doi.org/10.1016/0006-8993(77)90036-1
https://doi.org/10.1016/0006-8993(77)90036-1
Autor:
Dean R. Haubrich, Nancy H. Gerber
Publikováno v:
Biochemical Pharmacology. 30:2993-3000
Although choline has proven useful in the treatment of neurological disorders, its duration of action is limited by its rapid rate of metabolism. In order to evaluate the role of choline dehydrogenase in regulation of choline metabolism, some of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64ed1f0d47d9e455f95f757654fa1638
https://doi.org/10.1016/0006-2952(81)90265-3
https://doi.org/10.1016/0006-2952(81)90265-3
Autor:
Susan J. Ward, Marla J. Silbernagel, Daniel Luttinger, Mark H. Perrone, Dean R. Haubrich, Dennis J. Hlasta
Publikováno v:
Journal of Medicinal Chemistry. 30:1555-1562
The synthesis and alpha 2-adrenergic activity of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines are described. The indolin-2-yl imidazoline 4b was found to possess potent alpha 2-adrenergic agonist and antagonist activity. The modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a426ec4886de5704a3c94f724d943e
https://doi.org/10.1021/jm00392a005
https://doi.org/10.1021/jm00392a005
Publikováno v:
Journal of Medicinal Chemistry. 25:113-116
A series of 6- and 8-(aminomethyl)-4H-1,2,4-benzothiadiazine 1,1-dioxides has been synthesized and tested for interaction with various GABA systems. None of the compounds showed significant GABA-mimetic properties, but unexpectedly, compound 7 [6-(am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5fcbe3138311107ec8a724a57eccf1
https://doi.org/10.1021/jm00344a004
https://doi.org/10.1021/jm00344a004
Autor:
Paulina F.L. Wang, Dean R. Haubrich
Publikováno v:
Biochemical Pharmacology. 25:669-672
Inhibition by juglone (5-hydroxy-l,4-naphthoquinone) of choline acetyltransferase [ChAt; acetyl-CoA: choline O-acetyltransferase (EC 2.3.1.6)] of rabbit brain was noncompetitive for choline and not reversible by dialysis. When acetyl-CoA and juglone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf1654addd58ec2ca6b6d7b2570ad11
https://doi.org/10.1016/0006-2952(76)90242-2
https://doi.org/10.1016/0006-2952(76)90242-2
Publikováno v:
Brain Research. 231:216-221
Neurotensin administered into the rat brain lowered the concentration of dopamine in the corpus striatum and selectively blocked rearing induced by amphetamine. In addition, the peptide inhibited synaptosomal synthesis of dopamine in vitro, with an I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99113b08eb0e5b231a9aec2c172c5699
https://doi.org/10.1016/0006-8993(82)90022-1
https://doi.org/10.1016/0006-8993(82)90022-1
Autor:
Dean R. Haubrich, Donald E. Blake
Publikováno v:
Life Sciences. 10:175-180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23abc508514228304687fde166401c26
https://doi.org/10.1016/0024-3205(71)90091-9
https://doi.org/10.1016/0024-3205(71)90091-9