Výsledky vyhledávání - "Dean Popovski"

Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy

Autor: Jason E. Cain, Annie Huang, Peter Downie, Dean Popovski, Elizabeth M. Algar, Claire Sun, Ron Firestein, Vijesh Vaghjiani, Paul Wood, Sarah Parackal, W. Samantha N. Jayasekara, David M. Ashley, Wai Chin Chong, Sara Khan

Publikováno v: Cancers
Volume 13
Issue 20
Cancers, Vol 13, Iss 5145, p 5145 (2021)

Simple Summary Atypical teratoid rhabdoid tumour (ATRT) is an aggressive undifferentiated malignancy of the central nervous system in children. A defining feature of ATRT is the loss of the SMARCB1 gene that is essential for regulating gene expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe342d313b3a80f7751b676fc1e026
https://doi.org/10.3390/cancers13205145

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TBIO-02. IMMUNE PROFILING OF RARE EMBRYONAL BRAIN TUMORS REVEAL EVIDENCE OF DYSREGULATED INTERFERON SIGNALLING AS A POTENTIAL DETERMINANT OF IMMUNOLOGICAL HETEROGENEITY

Autor: Annie Huang, Andrew Bondoc, Holly Lindsay, Fupan Yao, James T. Rutka, Dean Popovski, Salma Al-Karmi, Ben Ho, Xiao-Nan Li

Publikováno v: Neuro-Oncology

Embryonal brain tumors (EBTs) remain the most common malignant pediatric brain tumors. Despite recent advances and improved understanding of the molecular biology of EBTs, clinical outcomes remain poor for rare EBTs. Previous large-scale genomic stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e12d90a31bb4806fadebc0b6be281e1
http://europepmc.org/articles/PMC7715316

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ATRT-03. TARGETED CATALYTIC INHIBITION OF EZH2 SYNERGIZES WITH LOW-DOSE PANOBINOSTAT IN MALIGNANT RHABDOID TUMOR

Autor: Dean Popovski, Catherine Cochrane, Elizabeth Algar, Anette Szczepny, Samantha Jayasekara, David Ashley, Peter Downie, Neil Watkins, Jason Cain

Malignant Rhabdoid Tumor (MRT) is a rare pediatric cancer predominantly occurring in the kidney and CNS that is highly resistant to current treatment protocols. MRT is almost exclusively characterized by homozygous inactivation of SMARCB1, a critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429ccc557fcf006c5322bbd16747af76
https://europepmc.org/articles/PMC5474967/

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Investigation into the Biology of Human Malignant Rhabdoid Tumour

Autor: DEAN POPOVSKI

My study focused on Malignant Rhabdoid Tumor (MRT) a resistant pediatric cancer where the primary mutation is loss of SMARCB1, implicating epigenetic deregulation as central to the pathogenesis of the disease. We demonstrated that repurposing the HDA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ede3a4f5ed269c9b1ced30af053acdf

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PDTM-06. TARGETED CATALYTIC INHIBITION OF EZH2 SYNERGIZES WITH LOW-DOSE PANOBINOSTAT IN MALIGNANT RHABDOID TUMOR

Autor: Peter Downie, Catherine R Cochrane, Jason E. Cain, D. Neil Watkins, Anette Szczepny, Dean Popovski, W. Samantha N. Jayasekara, Elizabeth M. Algar, David M. Ashley

Publikováno v: Neuro-Oncology. 19:vi190-vi191

Malignant Rhabdoid Tumor (MRT) is a rare pediatric cancer predominant in the kidney and CNS that is resistant to current treatment regimes. MRT is genetically characterized by homozygous inactivation of SMARCB1, a core subunit of the SWI/SNF chromati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b10655e35ed3319ac91b6aa8429083
https://doi.org/10.1093/neuonc/nox168.771

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Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors

Autor: Andrea Muscat, David M. Ashley, W. Samantha N. Jayasekara, D. Neil Watkins, Jason E. Cain, Melissa J Ferguson, Kieren M Marini, Peter Downie, Fernando J. Rossello, Muhammand Alamgeer, Elizabeth M. Algar, Dean Popovski

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 22(14)

Purpose: Malignant rhabdoid tumor (MRT) and atypical teratoid rhabdoid tumors (ATRT) are rare aggressive undifferentiated tumors primarily affecting the kidney and CNS of infants and young children. MRT are almost exclusively characterized by homozyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370b21feb2fa58a6eb930c167cfc97f5
https://pubmed.ncbi.nlm.nih.gov/26920892

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Abstract 3360: Targeted catalytic inhibition of EZH2 synergizes with low-dose HDACi in malignant rhabdoid tumors

Autor: Jason E. Cain, Peter Downie, W. Samantha N. Jayasekara, Catherine R. Cochrane, D. Neil Watkins, Anette Szczepny, Dean Popovski, David M. Ashley, Elizabeth M. Algar

Publikováno v: Cancer Research. 77:3360-3360

Malignant Rhabdoid Tumor (MRT) is a rare pediatric cancer of the kidney and CNS that is resistant to current treatment protocols. MRT is genetically characterized by homozygous inactivation of SMARCB1, a critical subunit of the SWI/SNF chromatin-remo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2abca3c5b6a3bc5762e1e80a822cd454
https://doi.org/10.1158/1538-7445.am2017-3360

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