Výsledky vyhledávání - "Dean Petkanas"

Pharmacological Comparisons between Cannabidiol and KLS-13019

Autor: William A. Kinney, Dean Petkanas, Douglas E. Brenneman

Cannabidiol (CBD) exhibits neuroprotective properties in many experimental systems. However, development of CBD as a drug has been confounded by the following: (1) low potency; (2) a large number of molecular targets; (3) marginal pharmacokinetic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544c7edadd12b0db089174d01ccb74a7
https://europepmc.org/articles/PMC6150782/

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Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability

Autor: Zhijie Cai, William A. Kinney, Hua Marlon Zhong, Tao Qian, Wei Ling, Lanyi Yang, Douglas E. Brenneman, Yu Chen, Dean Petkanas, Mcdonnell Mark, Chaomin Liu

Cannabidiol is the nonpsychoactive natural component of C. sativa that has been shown to be neuroprotective in multiple animal models. Our interest is to advance a therapeutic candidate for the orphan indication hepatic encephalopathy (HE). HE is a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d986f7c53831bcdf2136cb832d126e4
https://europepmc.org/articles/PMC4834656/

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