Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dean Paes"'
Autor:
Melissa Schepers, Assia Tiane, Dean Paes, Selien Sanchez, Ben Rombaut, Elisabeth Piccart, Bart P. F. Rutten, Bert Brône, Niels Hellings, Jos Prickaerts, Tim Vanmierlo
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by heterogeneous clinical symptoms including gradual muscle weakness, fatigue, and cognitive impairment. The disease course of MS can be clas
Externí odkaz:
https://doaj.org/article/dc3cae650c4b4578a8894e682b9ed38c
Autor:
Melissa Schepers, Dean Paes, Assia Tiane, Ben Rombaut, Elisabeth Piccart, Lieve van Veggel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Chiara Brullo, Olga Bruno, Ernesto Fedele, Roberta Ricciarelli, Charles ffrench-Constant, Marie E. Bechler, Pauline van Schaik, Wia Baron, Evy Lefevere, Kobi Wasner, Anne Grünewald, Catherine Verfaillie, Paulien Baeten, Bieke Broux, Paul Wieringa, Niels Hellings, Jos Prickaerts, Tim Vanmierlo
Publikováno v:
Brain Behavior and Immunity, 109, 1-22. Elsevier Science
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by focal inflammatory lesions and prominent demyelination. Even though the currently available therapies are effective in treating the initial s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b770c84050d1fd6b3d56d5c62397da38
http://orbilu.uni.lu/handle/10993/53476
http://orbilu.uni.lu/handle/10993/53476
Autor:
Jos Prickaerts, Melissa Schepers, Tim Vanmierlo, Ben Rombaut, Dean Paes, Daniel L.A. van den Hove
Publikováno v:
Pharmacological Reviews. 73:1016-1049
The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases
Autor:
Britt T.J. van Hagen, Nick P. van Goethem, Ellis Nelissen, Dean Paes, Karin Koymans, Scott van Hoof, Rudy Schreiber, Mark Varney, Adrian Newman-Tancredi, Jos Prickaerts
Publikováno v:
Molecular and Cellular Neuroscience, 120:103719. Elsevier Science
Molecular and cellular neuroscience, 120:103719. Academic Press Inc.
Molecular and cellular neuroscience 120, 103719 (2022). doi:10.1016/j.mcn.2022.103719
Molecular and cellular neuroscience, 120:103719. Academic Press Inc.
Molecular and cellular neuroscience 120, 103719 (2022). doi:10.1016/j.mcn.2022.103719
Pattern separation is a hippocampal process in which highly similar stimuli are recognized as separate representations, and deficits could lead to memory impairments in neuropsychiatric disorders such as schizophrenia. The 5-HT1A receptor (5-HT1AR) i
Autor:
Melissa Schepers, Ben Rombaut, Sofie Kessels, Dean Paes, Yevgeniya Solomina, Daniel L.A. van den Hove, Elisabeth Piccart, Assia Tiane, Jos Prickaerts, Tim Vanmierlo, Bert Brône
Publikováno v:
Theranostics
Synapses are the functional units of the brain. They form specific contact points that drive neuronal communication and are highly plastic in their strength, density, and shape. A carefully orchestrated balance between synaptogenesis and synaptic pru
Autor:
Ellis Nelissen, Britt T.J. van Hagen, Elentina K. Argyrousi, Nick P. van Goethem, Pim R.A. Heckman, Dean Paes, Danielle A.J. Mulder-Jongen, Johannes G. Ramaekers, Arjan Blokland, Harald H.H.W. Schmidt, Jos Prickaerts
Publikováno v:
Neuroscience Letters, 788:136840. Elsevier Ireland Ltd
Soluble guanylate cyclase (sGC) - cyclic guanosine monophosphate (cGMP) signalling is important for healthy memory function and a healthy vascular system. Targeting sGC-cGMP signalling can therefore be a potential strategy to enhance memory processes
Publikováno v:
Trends in Pharmacological Sciences. 40:971-985
Phosphodiesterases (PDEs) have been an interesting drug target for many diseases. Although a vast number of mainly preclinical studies demonstrates beneficial effects of PDE inhibitors for central nervous system (CNS) diseases, no drugs are currently
Autor:
Britt T J, van Hagen, Nick P, van Goethem, Ellis, Nelissen, Dean, Paes, Karin, Koymans, Scott, van Hoof, Rudy, Schreiber, Mark, Varney, Adrian, Newman-Tancredi, Jos, Prickaerts
Publikováno v:
Molecular and cellular neurosciences. 120
Pattern separation is a hippocampal process in which highly similar stimuli are recognized as separate representations, and deficits could lead to memory impairments in neuropsychiatric disorders such as schizophrenia. The 5-HT
Publikováno v:
Neuropharmacology, 184:108414. Elsevier Science
Phosphodiesterases (PDE) are the only enzymes that degrade cAMP and cGMP which are second messengers crucial to memory consolidation. Different PDE inhibitors have been developed and tested for their memory-enhancing potential, but the occurrence of
Autor:
Tim Vanmierlo, Katie Lunnon, Dean Paes, Diego Mastroeni, Janou A. Y. Roubroeks, Daniel L.A. van den Hove, Ehsan Pishva, Elaine Delvaux, Paul D. Coleman, Roy Lardenoije, Melissa Schepers, Riccardo M. Carollo, Jos Prickaerts
Publikováno v:
Neurobiology of Aging, 97, 56-64. Elsevier Science
Pharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic potential to restore memory function in Alzheimer's disease (AD), but will likely evoke adverse side effects. As PDE4D encodes multiple isoforms, targeting specific isoforms ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5700354515d40386a8c31e7384e6587
http://hdl.handle.net/1942/33241
http://hdl.handle.net/1942/33241