Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Dean O Campbell"'
Autor:
Gaëlle H. Martin, Alexis Gonon, Perrine Martin-Jeantet, Florence Renart-Depontieu, Zuzana Biesova, Anokhi Cifuentes, Arnab Mukherjee, Thomas Thisted, Astrid Doerner, Dean O. Campbell, Ludovic Bourré, Edward H. van der Horst, Amélie Rezza, Kader Thiam
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectivesDespite their efficacy, some immunotherapies have been shown to induce immune-related adverse events, including the potentially life-threatening cytokine release syndrome (CRS), calling for reliable and translational preclinical models to p
Externí odkaz:
https://doaj.org/article/f1b517b31b7b45c781d7edf8fa9804ce
Publikováno v:
Theranostics, Vol 2, Iss 1, Pp 374-391 (2012)
Positron emission tomography (PET) imaging reporter genes (IRGs) and PET reporter probes (PRPs) are amongst the most valuable tools for gene and cell therapy. PET IRGs/PRPs can be used to non-invasively monitor all aspects of the kinetics of therapeu
Externí odkaz:
https://doaj.org/article/2828569451274e1b843976903da14e5d
Autor:
Perrine Martin-Jeantet, Florence Renart-Depontieu, Ludovic Bourre, Gaëlle Martin, Angela Pappalardo, Dean O. Campbell, Astrid Doerner, Yacine Cherifi, Fabiane Sônego, Kader Thiam
Publikováno v:
Cancer Research. 82:4036-4036
T cell engagers show high efficacy in B cells malignances. High risk of immune-related adverse events, including cytokine release syndrome (CRS), is reported in patients due to on-target off-site effects of T cell engagers. Thus, reliable and transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec5f451ab5b124711208100f60d2f163
https://doi.org/10.1158/1538-7445.am2022-4036
https://doi.org/10.1158/1538-7445.am2022-4036
Autor:
Sosuke Miyoshi, Akihiro Noda, Hiroshi Fushiki, Alla Verlinsky, Peng Yang, Yoshihiro Murakami, Sergio Lacayo, Dean O Campbell, Edward Cabral, David R. Stover, Ingrid B.J.K. Joseph, Yuji Fujita, Josh Snyder
Publikováno v:
Molecular imaging and biology. 18(5)
Nectin-4 is selectively overexpressed in a variety of cancers and is currently under clinical investigation as a therapeutic target. A monoclonal antibody against nectin-4 (AGS-22M6) was evaluated as an Immuno-positron emission tomography (ImmunoPET)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e96d95b5b8e8ab13cda808352f45c2
https://pubmed.ncbi.nlm.nih.gov/27122234
https://pubmed.ncbi.nlm.nih.gov/27122234
Publikováno v:
Journal of Nuclear Medicine. 53:275-280
The ability to measure tumor determinants of response to nucleoside analog (NA) chemotherapy agents such as gemcitabine and related compounds could significantly affect the management of several types of cancer. Previously we showed that the accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6440102eafa173029f08389c1ae23fc
https://doi.org/10.2967/jnumed.111.090407
https://doi.org/10.2967/jnumed.111.090407
Autor:
Martin S. Auerbach, Arnon Lavie, Jason T. Lee, Ying Su, Dean O. Campbell, Caius G. Radu, Harvey R. Herschman, Nagichettiar Satyamurthy, Johannes Czernin, Shahriar S. Yaghoubi
Publikováno v:
Journal of Biological Chemistry. 287:446-454
Positron emission tomography (PET) reporter gene imaging can be used to non-invasively monitor cell-based therapies. Therapeutic cells engineered to express a PET reporter gene (PRG) specifically accumulate a PET reporter probe (PRP) and can be detec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facf83dcc4ac9920a744265b61972126
https://doi.org/10.1074/jbc.m111.314666
https://doi.org/10.1074/jbc.m111.314666
Autor:
Nagichettiar Satyamurthy, Owen N. Witte, Jason T. Lee, Michael E. Phelps, Chengyi J. Shu, Johannes Czernin, Caius G. Radu, Dean O. Campbell, Jordan Wengrod, Andrew Q. Tran
Publikováno v:
Journal of Nuclear Medicine. 51:1092-1098
Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway and a critical determinant of therapeutic activity for several nucleoside analog prodrugs. We have previously reported the development of 1-(2′-deoxy-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52dcbfb8f725cc63fee8ee37ef46fdb0
https://doi.org/10.2967/jnumed.109.073361
https://doi.org/10.2967/jnumed.109.073361
Autor:
Xiaoxiao Li, Michael E. Phelps, Sarah Brewer, Mireille Riedinger, Caius G. Radu, Evan Nair-Gill, Stephanie M. Wiltzius, Bo Wei, Ling Chen, Jonathan Braun, Dean O. Campbell, Nagichettiar Satyamurthy, Owen N. Witte
Publikováno v:
Gastroenterology. 138:1266-1275
Background & Aims Uptake of [18F]1-(2′-deoxy-2′-arabinofuranosyl)cytosine (D-FAC) is a trait of activated lymphocytes; its biodistribution predominates in the spleen, thymus, and bone marrow. In addition, D-FAC is taken up at high levels by the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ec65b5d69a05fac4ba1cee2dbf2478
https://doi.org/10.1053/j.gastro.2010.01.003
https://doi.org/10.1053/j.gastro.2010.01.003
Publikováno v:
Biochemistry. 45:10591-10605
In the Neurospora VS ribozyme, magnesium ions facilitate formation of a loop-loop interaction between stem-loops I and V, which is important for recognition and activation of the stem-loop I substrate. Here, we present the high-resolution NMR structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511f7e122bcf3b42fb27bd83cbb356d4
https://doi.org/10.1021/bi0607150
https://doi.org/10.1021/bi0607150
Autor:
Dean O. Campbell, Nuttee Suree, Robert T. Clubb, Rosemarie M. Pilpa, Michael E. Jung, Jeremy J. Clemens, Chu Kong Liew
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5076-5079
l -Threonine 2 was converted in seven steps into the protected aminomercaptoalcohol 8, a threonine mimic. This compound 8 was coupled to various oligopeptides to produce two different tetrapeptide analogues, for example, 11 and 17, which were shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e6580f7b1d23882fe97d1e96757495
https://doi.org/10.1016/j.bmcl.2005.07.073
https://doi.org/10.1016/j.bmcl.2005.07.073