Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Dean Nizetic"'
Autor:
Alexandra Botté, Jeanne Lainé, Laura Xicota, Xavier Heiligenstein, Gaëlle Fontaine, Amal Kasri, Isabelle Rivals, Pollyanna Goh, Orestis Faklaris, Jack-Christophe Cossec, Etienne Morel, Anne-Sophie Rebillat, Dean Nizetic, Graça Raposo, Marie-Claude Potier
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Abstract Enlarged early endosomes have been visualized in Alzheimer’s disease (AD) and Down syndrome (DS) using conventional confocal microscopy at a resolution corresponding to endosomal size (hundreds of nm). In order to overtake the diffraction
Externí odkaz:
https://doaj.org/article/26fd67e10b014d1ab8afbad372ac26f6
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 4, Pp 739-747 (2020)
MiR-219 and miR-338 (miR-219/miR-338) are oligodendrocyte-specific microRNAs. The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes, which may enhance axonal remyelinat
Externí odkaz:
https://doaj.org/article/2325957e451a439f863a2c8593a18a36
Autor:
Andre Strydom, Amanda Heslegrave, Carla M. Startin, Kin Y. Mok, John Hardy, Jurgen Groet, Dean Nizetic, Henrik Zetterberg, The LonDownS Consortium
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-5 (2018)
Abstract Background Down syndrome (DS) may be considered a genetic form of Alzheimer’s disease (AD) due to universal development of AD neuropathology, but diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. A potenti
Externí odkaz:
https://doaj.org/article/7f6f6b90ae554b1b950bfb127b77dd79
Autor:
Carla M. Startin, Bryony Lowe, Sarah Hamburg, Rosalyn Hithersay, Andre Strydom, LonDownS Consortium, Elizabeth Fisher, Dean Nizetic, John Hardy, Victor Tybulewicz, Annette Karmiloff-Smith
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularly for those with more severe intellect
Externí odkaz:
https://doaj.org/article/0df03a1e409e4ad29d4236f3f13e6da8
Autor:
Lewis Buss, Elizabeth Fisher, John Hardy, Dean Nizetic, Jurgen Groet, Laura Pulford, André Strydom
Publikováno v:
F1000Research, Vol 5 (2016)
Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the brain parenchyma and in vessel
Externí odkaz:
https://doaj.org/article/08a5d4149dd544e0bff68b902fb8ac88
Autor:
Annette Karmiloff-Smith, Tamara Al-Janabi, Hana D'Souza, Jurgen Groet, Esha Massand, Kin Mok, Carla Startin, Elizabeth Fisher, John Hardy, Dean Nizetic, Victor Tybulewicz, Andre Strydom
Publikováno v:
F1000Research, Vol 5 (2016)
In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences
Externí odkaz:
https://doaj.org/article/bb058b43bffa4d67938df02e21160e7a
Autor:
M Reza Sailani, Federico A Santoni, Audrey Letourneau, Christelle Borel, Periklis Makrythanasis, Youssef Hibaoui, Konstantin Popadin, Ximena Bonilla, Michel Guipponi, Corinne Gehrig, Anne Vannier, Frederique Carre-Pigeon, Anis Feki, Dean Nizetic, Stylianos E Antonarakis
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135555 (2015)
DNA methylation is essential in mammalian development. We have hypothesized that methylation differences induced by trisomy 21 (T21) contribute to the phenotypic characteristics and heterogeneity in Down syndrome (DS). In order to determine the methy
Externí odkaz:
https://doaj.org/article/f3c323cb09464768afde2d100f29c9f2
Publikováno v:
Journal of Alzheimer's disease : JAD.
Alzheimer’s disease (AD) is the most common cause of dementia that affects millions of predominantly elderly individuals worldwide. Despite intensive research over several decades, controversies still surround the etiology of AD and the disease rem
Autor:
Pollyanna Goh, Regina Trollmann, Marielle Minere, Saad Hannan, Bernt Popp, Charlotte J. Maughan Jones, Aida Helana Binti Affandi, Trevor G. Smart, Dean Nizetic, Gary Warnes
Publikováno v:
The Journal of Neuroscience. 40:5518-5530
GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature prominently in excitability disorders and neurodevelopmental deficits following disruption to GABA
Autor:
Ana Cindric, Frano Vuckovic, David Koschut, Vincenzo Borelli, Julija Juric, Maja Pucic-Bakovic, Anita Slana, Helena Deris, Azra Frkatović, Aoife Murray, Ivan Alic, Jurgen Groet, Niamh O’Brien, Drazen Petrovic, Sarah Hamburg, Carla Startin, Rosalyn Hithersay, Hana D’Souza, LonDownS Consortium, Tim Spector, Dinko Mitrecic, Mijana Kero, Ljubica Odak, Ingeborg Barisic, Michael Thomas, Andre Strydom, Anne-Sophie Rebillat, Claudio Franceschi, Gordan Lauc, Jasminka Kristic, Dean Nizetic
Cells from people with Down syndrome (DS) show faster accumulation of DNA damage and epigenetic aging marks. Causative mechanisms remain un-proven and hypotheses range from amplified chromosomal instability to actions of several supernumerary chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::548515c2398e5b88c12e6b8f505b6b96
https://doi.org/10.21203/rs.3.rs-1128079/v1
https://doi.org/10.21203/rs.3.rs-1128079/v1