Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dean L. Pountney"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/fdd04ecb021347da955dff1822a5cc59
Autor:
Matthew K. Boag, Linlin Ma, George D. Mellick, Dean L. Pountney, Yunjiang Feng, Ronald J. Quinn, Alan Wee-Chung Liew, Mahendiran Dharmasivam, Mahan Gholam Azad, Rizwana Afroz, Des R. Richardson
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102136- (2021)
Autonomously spiking dopaminergic neurons of the substantia nigra pars compacta (SNpc) are exquisitely specialized and suffer toxic iron-loading in Parkinson's disease (PD). However, the molecular mechanism involved remains unclear and critical to de
Externí odkaz:
https://doaj.org/article/0a4d3dd63b704e99bab121ccde7b7f52
Autor:
Danuta Z. Loesch, Flora Tassone, Anna Atkinson, Paige Stimpson, Nicholas Trost, Dean L. Pountney, Elsdon Storey
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2021)
Expansions of the CGG repeat in the non-coding segment of the FMR1 X-linked gene are associated with a variety of phenotypic changes. Large expansions (>200 repeats), which cause a severe neurodevelopmental disorder, the fragile x syndrome (FXS), are
Externí odkaz:
https://doaj.org/article/4431b2654c574dbeb0e433fd4765a036
Autor:
Dario Valdinocci, Rui F. Simões, Jaromira Kovarova, Teresa Cunha-Oliveira, Jiri Neuzil, Dean L. Pountney
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
The appearance of alpha-synuclein-positive inclusion bodies (Lewy bodies) and the loss of catecholaminergic neurons are the primary pathological hallmarks of Parkinson’s disease (PD). However, the dysfunction of mitochondria has long been recognize
Externí odkaz:
https://doaj.org/article/96c80329a09d4b26905a4c30cfe84eb7
Autor:
Bruno Di Marco Vieira, Rowan A. W. Radford, Junna Hayashi, Emma D. Eaton, Ben Greenaway, Mark Jambas, Eugen B. Petcu, Roger S. Chung, Dean L. Pountney
Publikováno v:
Life, Vol 10, Iss 9, p 183 (2020)
Multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) are α-synucleinopathies that exhibit widespread astrogliosis as a component of the neuroinflammatory response. Munc18, a protein critical to vesicle exocytosis, was previously found t
Externí odkaz:
https://doaj.org/article/e0b3f8362bed43c2afc12b9eed488836
Publikováno v:
Biomolecules, Vol 5, Iss 3, Pp 1697-1716 (2015)
α-Synuclein inclusion bodies are a pathological hallmark of several neurodegenerative diseases, including Parkinson’s disease, and contain aggregated α-synuclein and a variety of recruited factors, including protein chaperones, proteasome compone
Externí odkaz:
https://doaj.org/article/e266264ef1ff4cf795f192baa1a09e11
Publikováno v:
Biomolecules, Vol 4, Iss 3, Pp 795-811 (2014)
In Parkinson’s disease and some atypical Parkinson’s syndromes, aggregation of the α-synuclein protein (α-syn) has been linked to neurodegeneration. Many triggers for pathological α-syn aggregation have been identified, including port-translat
Externí odkaz:
https://doaj.org/article/e4bfa11578bc4cf6b8ca728ae46ff0d0
Autor:
Fleur A. McLeary, Alexandre N. Rcom-H’cheo-Gauthier, Michael Goulding, Rowan A. W. Radford, Yuho Okita, Peter Faller, Roger S. Chung, Dean L. Pountney
Publikováno v:
Cells, Vol 8, Iss 2, p 179 (2019)
The formation of cytotoxic intracellular protein aggregates is a pathological signature of multiple neurodegenerative diseases. The principle aggregating protein in Parkinson’s disease (PD) and atypical Parkinson’s diseases is α-synuclein (α-sy
Externí odkaz:
https://doaj.org/article/dad6a48b4e864abcb81692917788df72
Autor:
Rowan A. W. Radford, Stephanie L. Rayner, Paulina Szwaja, Marco Morsch, Flora Cheng, Tianyi Zhu, Jocelyn Widagdo, Victor Anggono, Dean L. Pountney, Roger Chung, Albert Lee
Publikováno v:
Journal of Neurochemistry. 165:563-586
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31b317f45107bb5a8d7a6fddc10112fe
https://doi.org/10.1111/jnc.15796
https://doi.org/10.1111/jnc.15796
Autor:
Xiaoyi Chen, Yunjiang Feng, Ronald J Quinn, Dean L Pountney, Des R. Richardson, George D Mellick, Linlin Ma
Publikováno v:
Pharmacological Reviews. :PHARMREV-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cfefe6374f3300fbb985912083d1e98
https://doi.org/10.1124/pharmrev.122.000743
https://doi.org/10.1124/pharmrev.122.000743