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The Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs

Autor: Marlon C. Rebelatto, Phaedra I. Cole, Paul E. Ross, Brigitte M. Richard, Abram N. Brubaker, Keith Nelson, Dean Haan, Laura R. Ott, Paul E. Newton

Publikováno v: Journal of Drug Delivery
Journal of Drug Delivery, Vol 2012 (2012)

A sustained-release DepoFoam injection formulation of bupivacaine (EXPAREL, 15 mg/mL) is currently being investigated for postsurgical analgesia via peripheral nerve block (PNB). Single-dose toxicology studies of EXPAREL (9, 18, and 30 mg/kg), bupiva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34d8e502740c14eaf3e192bf24e4c8b
https://doi.org/10.1155/2012/962101

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Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison

Autor: Dean Haan, Phaedra I. Cole, Douglas E. Rickert, Paul E. Ross, Brigitte M. Richard, Keith Nelson, Paul E. Newton, Laura R. Ott, Marlon C. Rebelatto, Abram N. Brubaker

Publikováno v: Journal of Drug Delivery, Vol 2011 (2011)
Journal of Drug Delivery

EXPAREL (bupivacaine extended-release liposome injection), DepoFoam bupivacaine, is in development for prolonged postsurgical analgesia. Repeat-dose toxicity studies were conducted in rabbits and dogs to compare the potential local and systemic toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6228d9f9f437fc2df82a4f1da3910f02
https://doi.org/10.1155/2011/467429

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The Safety of EXPAREL TM Bupivacaine Extended‐release Liposome Injection) Administered by Peripheral Nerve Block in Rabbits and Dogs

Autor: Brigitte M. Richard, Paul E. Newton, Phaedra I. Cole, Marlon C. Rebelatto, Abram N. Brubaker, Dean Haan, Paul E. Ross, Laura R. Ott, Keith Nelson

Publikováno v: The FASEB Journal. 25

Bupivacaine solutions have been used for many years by multiple routes with peripheral nerve block (PNB) becoming increasingly popular. A sustained-release DepoFoam® injection formulation of bupiva...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d903543b39f1dbd191a8cd25fa5a209
https://doi.org/10.1096/fasebj.25.1_supplement.lb398

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