Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Dean H. Kedes"'
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004066 (2014)
De novo infection with the gammaherpesvirus Rhesus monkey rhadinovirus (RRV), a close homolog of the human oncogenic pathogen, Kaposi's sarcoma-associated herpesvirus (KSHV), led to persistent activation of the MEK/ERK pathway and increasing nuclear
Externí odkaz:
https://doaj.org/article/c59e4ada38a54d929cf9fe132c1f908e
Autor:
Thomas J Ellison, Dean H Kedes
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111502 (2014)
The availability of reliable recombinant reporter virus systems has been a great boon to the study of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). Unexpectedly, we found that expression of the ostensibly constitutive green fluorescent protei
Externí odkaz:
https://doaj.org/article/c4a2b517ed374be38f705691a0436eb0
Publikováno v:
Proceedings of the National Academy of Sciences. 115:4992-4997
By engaging in a form of molecular piggybacking onto host chromatin, DNA tumor viruses ensure retention and segregation of their circular genomes (episomes) during sequential cell divisions. Despite elegant functional genetic and crystallographic stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a999d6f0021cccd88da22cfe3e4cd07e
https://doi.org/10.1073/pnas.1721638115
https://doi.org/10.1073/pnas.1721638115
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14535 (2011)
Infection with Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) often results in the development of fatal tumors in immunocompromised patients. Studies of renal transplant recipients show that use of the immunosuppressant drug rapamycin, an mTOR i
Externí odkaz:
https://doaj.org/article/a7126fdddb35445289730bbcbe2353c1
Publikováno v:
Journal of Virology
Productive viral infection often depends on the manipulation of the cytoskeleton. Herpesviruses, including rhesus monkey rhadinovirus (RRV) and its close homolog, the oncogenic human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus/human herp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73225730d60532180f38692def547d2
https://doi.org/10.1128/jvi.00304-17
https://doi.org/10.1128/jvi.00304-17
Autor:
Sanket Shah, Michael B. Sherman, Dean H. Kedes, Christine M. O'Connor, Z. Hong Zhou, Stan Schein, Jonathan Jih, Wong Hoi Hui
Publikováno v:
Structure (London, England : 1993), vol 22, iss 10
SummaryLike many double-stranded DNA viruses, tumor gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus withstand high internal pressure. Bacteriophage HK97 uses covalent chainmail for this purpose, but how this is ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8f9f3e19967abc59e8901b6f59b2de
https://doi.org/10.1016/j.str.2014.05.019
https://doi.org/10.1016/j.str.2014.05.019
Autor:
Dean H. Kedes, Evonne N. Woodson
Publikováno v:
Journal of Virology. 86:9721-9736
During their progression from intranuclear capsids to mature trilaminar virions, herpesviruses incorporate an extensive array of viral as well as a smaller subset of cellular proteins. Our laboratory previously reported that rhesus monkey rhadinoviru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe386d48c491dee5fd38cafc787ed14
https://doi.org/10.1128/jvi.00695-12
https://doi.org/10.1128/jvi.00695-12
Publikováno v:
Journal of Structural Biology. 161:419-427
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a recently discovered DNA tumor virus that belongs to the γ-herpesvirus subfamily. Though numerous studies on KSHV and other herpesviruses, in general, have revealed much about their multilayered o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549a1f37b32154a1b45aec1fc8d24882
https://doi.org/10.1016/j.jsb.2007.10.016
https://doi.org/10.1016/j.jsb.2007.10.016
Publikováno v:
Journal of Virology. 81:5079-5090
Lifelong infection is a hallmark of all herpesviruses, and their survival depends on countering host immune defenses. The human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) encodes an array of proteins that contribute to immune eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a494e312a841720d68f61ff0f4460086
https://doi.org/10.1128/jvi.02738-06
https://doi.org/10.1128/jvi.02738-06
Autor:
Chris Parsons, David Camerini, Jon Overdevest, Dean H. Kedes, Laura Adang, J. Robert Taylor, Christine M. O'Connor
Publikováno v:
Journal of Clinical Investigation. 116:1963-1973
To develop an animal model of Kaposi sarcoma–associated herpesvirus (KSHV) infection uniquely suited to evaluate longitudinal patterns of viral gene expression, cell tropism, and immune responses, we injected NOD/SCID mice intravenously with purifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b62577635c58b56e05773aa951a35c9
https://doi.org/10.1172/jci27249
https://doi.org/10.1172/jci27249