Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Dean Gilham"'
Autor:
Christopher D. Sarsons, Dean Gilham, Laura M. Tsujikawa, Sylwia Wasiak, Li Fu, Brooke D. Rakai, Stephanie C. Stotz, Agostina Carestia, Michael Sweeney, Ewelina Kulikowski
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2683 (2023)
Facioscapulohumeral dystrophy (FSHD) is a muscle disease caused by inappropriate expression of the double homeobox 4 (DUX4) gene in skeletal muscle, and its downstream activation of pro-apoptotic transcriptional programs. Inhibitors of DUX4 expressio
Externí odkaz:
https://doaj.org/article/51286032f8f3442ebfcdb580ce159e02
Autor:
Dean Gilham, Sylwia Wasiak, Brooke D. Rakai, Li Fu, Laura M. Tsujikawa, Christopher D. Sarsons, Agostina Carestia, Kenneth Lebioda, Jan O. Johansson, Michael Sweeney, Kamyar Kalantar-Zadeh, Ewelina Kulikowski
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1663 (2023)
Epigenetic mechanisms are implicated in transcriptional programs driving chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain and extraterminal (BET) proteins, which are epigenetic readers that modulate gene expre
Externí odkaz:
https://doaj.org/article/5093b38d0a6348ee86b12a6a465daa75
Autor:
Laura M. Tsujikawa, Olesya A. Kharenko, Stephanie C. Stotz, Brooke D. Rakai, Christopher D. Sarsons, Dean Gilham, Sylwia Wasiak, Li Fu, Michael Sweeney, Jan O. Johansson, Norman C.W. Wong, Ewelina Kulikowski
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113230- (2022)
Background: Bromodomain and extraterminal proteins (BETs) are more than just epigenetic regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the maintenance of higher order chromatin structure at Topologically Associa
Externí odkaz:
https://doaj.org/article/8f4df9e6c3304f019c787cc9d257dbda
Autor:
Sylwia Wasiak, Dean Gilham, Emily Daze, Laura M. Tsujikawa, Christopher Halliday, Stephanie C. Stotz, Brooke D. Rakai, Li Fu, Ravi Jahagirdar, Michael Sweeney, Jan O. Johansson, Norman C. W. Wong, Ewelina Kulikowski
Publikováno v:
Cardiovascular Therapeutics, Vol 2020 (2020)
Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma. Bromodomain and extraterminal (BET) proteins are epigenetic readers that regul
Externí odkaz:
https://doaj.org/article/f51d93da11054162b5cd4b953f4b5169
Autor:
Sylwia Wasiak, Laura M. Tsujikawa, Christopher Halliday, Stephanie C. Stotz, Dean Gilham, Ravi Jahagirdar, Kamyar Kalantar-Zadeh, Richard Robson, Michael Sweeney, Jan O. Johansson, Norman C. Wong, Ewelina Kulikowski
Publikováno v:
Kidney International Reports, Vol 3, Iss 3, Pp 711-721 (2018)
Introduction: Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Externí odkaz:
https://doaj.org/article/2137257e12454054b0edb1bd9ba53d1e
Autor:
Dean Gilham, Audrey L. Smith, Li Fu, Dalia Y. Moore, Abenaya Muralidharan, St. Patrick M. Reid, Stephanie C. Stotz, Jan O. Johansson, Michael Sweeney, Norman C. W. Wong, Ewelina Kulikowski, Dalia El-Gamal
Publikováno v:
Biomedicines, Vol 9, Iss 4, p 437 (2021)
Effective therapeutics are urgently needed to counter infection and improve outcomes for patients suffering from COVID-19 and to combat this pandemic. Manipulation of epigenetic machinery to influence viral infectivity of host cells is a relatively u
Externí odkaz:
https://doaj.org/article/8b03b3135664401a9fb2fafd2c706dc1
Autor:
Sylwia Wasiak, Dean Gilham, Laura M. Tsujikawa, Christopher Halliday, Karen Norek, Reena G. Patel, Kevin G. McLure, Peter R. Young, Allan Gordon, Ewelina Kulikowski, Jan Johansson, Michael Sweeney, Norman C. Wong
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 1280-1288 (2016)
Apabetalone (RVX-208) inhibits the interaction between epigenetic regulators known as bromodomain and extraterminal (BET) proteins and acetyl-lysine marks on histone tails. Data presented here supports the manuscript published in Atherosclerosis “R
Externí odkaz:
https://doaj.org/article/77caca05f7d1404289ffafd96d666b46
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 2, Pp 375-383 (2006)
Human triacylglycerol hydrolase (hTGH) has been shown to play a role in hepatic lipid metabolism. Triacylglycerol hydrolase (TGH) hydrolyzes insoluble carboxylic esters at lipid/water interfaces, although the mechanism by which the enzyme adsorbs to
Externí odkaz:
https://doaj.org/article/a0d455e3896b4ce49a58d2d887062c1f
Autor:
Tamara R Castañeda, William Abplanalp, Sung Hee Um, Paul T Pfluger, Brigitte Schrott, Kimberly Brown, Erin Grant, Larissa Carnevalli, Stephen C Benoit, Donald A Morgan, Dean Gilham, David Y Hui, Kamal Rahmouni, George Thomas, Sara C Kozma, Deborah J Clegg, Matthias H Tschöp
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32631 (2012)
Targeted deletion of S6 kinase (S6K) 1 in mice leads to higher energy expenditure and improved glucose metabolism. However, the molecular mechanisms controlling these effects remain to be fully elucidated. Here, we analyze the potential role of dieta
Externí odkaz:
https://doaj.org/article/7da010e228ee4cde9cfbd8ad394306a7
Autor:
Kulikowski, Dean Gilham, Sylwia Wasiak, Brooke D. Rakai, Li Fu, Laura M. Tsujikawa, Christopher D. Sarsons, Agostina Carestia, Kenneth Lebioda, Jan O. Johansson, Michael Sweeney, Kamyar Kalantar-Zadeh, Ewelina
Publikováno v:
Biomedicines; Volume 11; Issue 6; Pages: 1663
Epigenetic mechanisms are implicated in transcriptional programs driving chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain and extraterminal (BET) proteins, which are epigenetic readers that modulate gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::118a5baffcf8b2f837c221d8d4809cd6