Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Dean G Tang"'
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90022 (2014)
Lung cancer is among the most lethal malignancies with a high metastasis and recurrence rate, which is probably due to the existence of lung cancer stem cells (CSCs). CSCs in many tumors including non-small cell lung cancer (NSCLC) have been identifi
Externí odkaz:
https://doaj.org/article/dfcb46033b9a476ca19adf3a13da67be
Autor:
Bigang Liu, Mark D Badeaux, Grace Choy, Dhyan Chandra, Irvin Shen, Collene R Jeter, Kiera Rycaj, Chia-Fang Lee, Maria D Person, Can Liu, Yueping Chen, Jianjun Shen, Sung Yun Jung, Jun Qin, Dean G Tang
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90615 (2014)
Human Nanog1 is a 305-amino acid (aa) homeodomain-containing transcription factor critical for the pluripotency of embryonic stem (ES) and embryonal carcinoma (EC) cells. Somatic cancer cells predominantly express a retrogene homolog of Nanog1 called
Externí odkaz:
https://doaj.org/article/36c6aa8971ff4673a71d9cfbc89ddf0c
Autor:
Li Zhang, Ruijing Xiao, Jie Xiong, Jun Leng, Altaf Ehtisham, Yi Hu, Qianshan Ding, Hui Xu, Shengwu Liu, Jin Wang, Dean G Tang, Qiuping Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52384 (2013)
We have previously demonstrated that the CCR9/CCL25 signaling pathway plays an important role in drug resistance in human acute T-lymphocytic leukemia (T-ALL) by inducing activation of ERM protein with polarized distribution in T-ALL cell line MOLT4.
Externí odkaz:
https://doaj.org/article/a2c912b2d9c04f07a8f48c0d30b710db
Autor:
Xin Chen, Bigang Liu, Qiuhui Li, Sofia Honorio, Xin Liu, Can Liu, Asha S Multani, Tammy Calhoun-Davis, Dean G Tang
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56903 (2013)
Reconstitution of tumor development in immunodeficient mice from disaggregated primary human tumor cells is always challenging. The main goal of the present study is to establish a reliable assay system that would allow us to reproducibly reconstitut
Externí odkaz:
https://doaj.org/article/d236c0576c4e4a00b9a91d3638739d12
Autor:
Hong Yan, Xin Chen, Qiuping Zhang, Jichao Qin, Hangwen Li, Can Liu, Tammy Calhoun-Davis, Luis Della Coletta, Jim Klostergaard, Izabela Fokt, Stanislaw Skora, Waldemar Priebe, Yongyi Bi, Dean G Tang
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24397 (2011)
Cancer stem cells (CSCs) possess high tumor-initiating capacity and have been reported to be resistant to therapeutics. Vice versa, therapy-resistant cancer cells seem to manifest CSC phenotypes and properties. It has been generally assumed that drug
Externí odkaz:
https://doaj.org/article/c7e5d31bf56b45a887f8e349390ab53d
Autor:
Honghao Zhang, Raghu Gogada, Neelu Yadav, Ravi K Lella, Mark Badeaux, Mary Ayres, Varsha Gandhi, Dean G Tang, Dhyan Chandra
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16379 (2011)
In the intrinsic death pathway, cytochrome C (CC) released from mitochondria to the cytosol triggers Apaf-1 apoptosome formation and subsequent caspase activation. This process can be recapitulated using recombinant Apaf-1 and CC in the presence of n
Externí odkaz:
https://doaj.org/article/c62ee9fc83aa43d88f344965e27bed6d
Autor:
Fengzhi Li, Xiang Ling, Sayan Chakraborty, Christos Fountzilas, Jianmin Wang, Anmbreen Jamroze, Xiaozhuo Liu, Pawel Kalinski, Dean G. Tang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-26 (2023)
Abstract There is increasing evidence indicating the significant role of DDX5 (also called p68), acting as a master regulator and a potential biomarker and target, in tumorigenesis, proliferation, metastasis and treatment resistance for cancer therap
Externí odkaz:
https://doaj.org/article/30e67990699f4a9691fd82d5b47de1b1
Autor:
Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Gröschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-25 (2023)
Abstract Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in m
Externí odkaz:
https://doaj.org/article/55713eefba5d493d89c7d396451b3eb7
Autor:
Wen (Jess) Li, Yunfei Wang, Xiaozhuo Liu, Shan Wu, Moyi Wang, Steven G. Turowski, Joseph A. Spernyak, Amanda Tracz, Ahmed M. Abdelaal, Kasireddy Sudarshan, Igor Puzanov, Gurkamal Chatta, Andrea L. Kasinski, Dean G. Tang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2123 (2024)
Prostate cancer (PCa) remains a common cancer with high mortality in men due to its heterogeneity and the emergence of drug resistance. A critical factor contributing to its lethality is the presence of prostate cancer stem cells (PCSCs), which can s
Externí odkaz:
https://doaj.org/article/e53665e2fdbf4db98c8a6545b64a0204
Autor:
Dean G. Tang
Publikováno v:
Seminars in Cancer Biology. 82:68-93
Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate tumors in different patients manifest significant inter-patient heterogeneity with respect to histo-morphological presentations and molecular architecture. A