Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Dean Falb"'
Autor:
Paul F. Miller, Mary Castillo, Caroline B. Kurtz, Kip A. West, Philippa J. Reeder, Binh Ha, Adam B. Fisher, Yves Millet, Vincent M. Isabella, Cami Leigh Anderson, David Lubkowicz, Dean Falb, Sarah Rowe, Christopher Bergeron, Sarah E. Guilmain, Ning Li, Munira Momin
Publikováno v:
Nature Biotechnology. 36:857-864
Phenylketonuria (PKU) is a genetic disease that is characterized by an inability to metabolize phenylalanine (Phe), which can result in neurotoxicity. To provide a potential alternative to a protein-restricted diet, we engineered Escherichia coli Nis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece3dcd9adaff9fea0acbd8dfe363f76
https://doi.org/10.1038/nbt.4222
https://doi.org/10.1038/nbt.4222
Autor:
Sunita Patel-Hett, Douglas Lazarus, Christian G. Peters, Amanda Leung, Sayaka Masuko, Dora E Kohnke, Lindsay Tomczak, Angelique Meredith, Brad Dykstra, Marcus Lehmann, Silvia Giannini, Dean Falb, Ryan Carpenter, Po-Shun Lee, Sophia Pete, Ashley J Russo
Publikováno v:
Blood. 138:1001-1001
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts ( Current treatment strategies for ITP include non-specific immunosuppression (steroids, rituximab), inhibition of platelet clearance (immunoglobulins, splen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b7f4593ede3ca470c693bd8ec511104
https://doi.org/10.1182/blood-2021-150823
https://doi.org/10.1182/blood-2021-150823
Autor:
Tian Lian Huang, Hongbin Zhang, Lindsay E. McDougall, Jennifer L. Shadrach, Tamara Tchkonia, Massimiliano Cerletti, Thien T. Tran, James L. Kirkland, Amy J. Wagers, Tim J. Schulz, Kristy L. Townsend, Denis Schrier, Yu-Hua Tseng, Nino Giorgadze, Dean Falb
Publikováno v:
Proceedings of the National Academy of Sciences. 108:143-148
Brown fat is specialized for energy expenditure and has therefore been proposed to function as a defense against obesity. Despite recent advances in delineating the transcriptional regulation of brown adipocyte differentiation, cellular lineage speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad01e2cc87b8b3d52ceae5522609a3a6
https://doi.org/10.1073/pnas.1010929108
https://doi.org/10.1073/pnas.1010929108
Publikováno v:
Cytokine & Growth Factor Reviews. 20:501-507
Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF beta super family. To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only BMPs used cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347ce14178c6b443989b312fb22118c9
https://doi.org/10.1016/j.cytogfr.2009.10.001
https://doi.org/10.1016/j.cytogfr.2009.10.001
Autor:
Moulay Hicham Alaoui-Ismaili, Alexander R. Vaccaro, Joseph Hong, Dean Falb, Huub Schellekens, James P. Lawrence, Chang Ju Hwang
Publikováno v:
Journal of Neurosurgery: Spine. 10:443-451
Object The object of this paper is to review the immunogenicity of bone morphogenetic proteins (BMPs) and to compare the results of the immunogenicity characterization and clinical consequences between recombinant human (rh)BMP-2 and recombinant huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8d230813ecc11e713a9d3fbc309dc66
https://doi.org/10.3171/2009.1.spine08473
https://doi.org/10.3171/2009.1.spine08473
Publikováno v:
Journal of Biological Chemistry. 283:20948-20958
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β superfamily of growth factors and are used clinically to induce new bone formation. The purpose of this study was to evaluate receptor utilization by BMP-2, BMP-4, BM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b6467b368674d50ed32746d584a3f6
https://doi.org/10.1074/jbc.m800850200
https://doi.org/10.1074/jbc.m800850200
Autor:
Dean Falb, Thomas Kamradt, Thomas J. Briner, Cheryl R. Bourque, Mohammad Luqman, Geoffrey H. Sunshine, Malcolm L. Gefter
Publikováno v:
European Journal of Immunology. 26:130-135
T cell tolerance can be induced in adult mice by injection of soluble antigenic peptide. The underlying mechanism has been difficult to establish in normal mice due to the low precursor frequency of T cells specific for any given antigen. Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03ba42cb31165a887027e9dae88f02c
https://doi.org/10.1002/eji.1830260120
https://doi.org/10.1002/eji.1830260120
Autor:
Moulay Hicham Alaoui-Ismaili, James P. Lawrence, Joseph Hong, Jeffrey S. Fischgrund, Chang Ju Hwang, Dean Falb, Alexander R. Vaccaro
Publikováno v:
Journal of neurosurgery. Spine. 13(4)
Object The aim in this study was to detect and quantify antibody responses against recombinant human osteogenic protein 1 (OP-1) and to compare these responses to patient clinical outcomes and safety information. Methods A controlled, open-label, ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90c43b06e39921add67855780102f5e
https://pubmed.ncbi.nlm.nih.gov/20887146
https://pubmed.ncbi.nlm.nih.gov/20887146
Autor:
Kening Song, SongTing Shi, Maarten van Dinther, Slobodan Vukicevic, Moulay Hicham Alaoui-Ismaili, Lovorka Grgurevic, Peter ten Dijke, Carola Krause, Robert Suto, Marilyn Elizabeth Patterson, Dean Falb
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 285(16), 12169-12180
Journal of Biological Chemistry, 285(16), 12169-12180
Bone morphogenetic proteins (BMPs) are used clinically to induce new bone formation in spinal fusions and long bone non-union fractures. However, large amounts of BMPs are needed to achieve these effects. BMPs were found to increase the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5bf7a8b67de65a5c6807f18ba56129
https://hdl.handle.net/1887/109500
https://hdl.handle.net/1887/109500
