Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Dean E, McNulty"'
Autor:
Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of beta-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2
Externí odkaz:
https://doaj.org/article/375cf7300ce44f4d81582faca63eef19
Autor:
Francesca Zappacosta, Dean E. McNulty, Mary Birchler, Christopher P. Evans, Matt Szapacs, Kevin McKinski
Publikováno v:
Journal of Pharmaceutical Analysis. 12:317-323
Inducible T-cell costimulator (ICOS) is a homodimeric protein expressed on the surface of activated T-cells that is being investigated as a potential therapeutic target to treat various cancers. Recent studies have reported aberrant increases in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce1232e39879d84f2a4ba865cc3bde9
https://doi.org/10.1016/j.jpha.2021.06.008
https://doi.org/10.1016/j.jpha.2021.06.008
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44c950954b0f6c38dfa2b274f54f21b
https://doi.org/10.1038/s43018-021-00249-x
https://doi.org/10.1038/s43018-021-00249-x
Autor:
David B. Sacks, Andrew C. Hedman, Zhigang Li, Roland S. Annan, Dean E. McNulty, Laëtitia Gorisse
Publikováno v:
Journal of Biological Chemistry. 295:18105-18121
IQGAP1 is a key scaffold protein that regulates numerous cellular processes and signaling pathways. Analogous to many other cellular proteins, IQGAP1 undergoes post-translational modifications, including phosphorylation. Nevertheless, very little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39c77bf32e6dc2ed3ca7c04d2c099d7
https://doi.org/10.1074/jbc.ra120.015891
https://doi.org/10.1074/jbc.ra120.015891
Autor:
Andrew B. Benowitz, Juan I. Luengo, Alexandra Stowell, Ali Raoof, Daniela Ennulat, Donald J. Ogilvie, Michael T. McCabe, Monica N. Montoute, Mark Cockerill, Allan M. Jordan, Wendy S. Halsey, Melissa B. Pappalardi, Zining Wu, Ian D. Waddell, Arthur Groy, Ryan G. Kruger, Lourdes Rueda, Charity Atkins, Roger J. Butlin, Elizabeth R. Gore, Edward Long, Aidan G. Gilmartin, Dean E. McNulty
Publikováno v:
Haematologica. 106:1979-1987
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of beta-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f30b512b7a990eb0505708d154fd943
https://doi.org/10.3324/haematol.2020.248658
https://doi.org/10.3324/haematol.2020.248658
Autor:
Jhon Alberto Ochoa-Alvarez, Harini Krishnan, Yongquan Shen, Nimish K Acharya, Min Han, Dean E McNulty, Hitoki Hasegawa, Toshinori Hyodo, Takeshi Senga, Jian-Guo Geng, Mary Kosciuk, Seung S Shin, James S Goydos, Dmitry Temiakov, Robert G Nagele, Gary S Goldberg
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41845 (2012)
Cancer is a leading cause of death of men and women worldwide. Tumor cell motility contributes to metastatic invasion that causes the vast majority of cancer deaths. Extracellular receptors modified by α2,3-sialic acids that promote this motility ca
Externí odkaz:
https://doaj.org/article/7f110612ff254de9a9dc675ae8f24378
Autor:
Jeffrey M. Stadel, Henry M. Sarau, Shelagh Wilson, Jeffrey S. Culp, Brian D. Hellmig, James J. Foley, Janet Park, Alison I. Muir, Jon K. Chambers, Robert S. Ames, J. Randall Slemmon, Dean E. McNulty, Derk J. Bergsma
Publikováno v:
G Protein-Coupled Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b48a2934c1ac3991b17c7c9fc6b9365
https://doi.org/10.1201/9780429129377-4
https://doi.org/10.1201/9780429129377-4
Autor:
Hong Zhang, Benjamin Schwartz, Michael D. Schaber, Mark A. Seefeld, Jon-Paul Jaworski, Guanglei Cui, Shu-Yun Zhang, Kelly Federowicz, Aidan G. Gilmartin, Faitg Thomas H, Martin Brandt, Jingsong Yang, Mark Richter, Robert B. Kirkpatrick, Dean E. McNulty, Neysa Nevins, Arthur Groy, Elsie Diaz, Rakesh Kumar, Stan F. Martens, Amber D. Jones, Dirk A. Heerding, Peng Xin, Robert H. Sinnamon, Elisabeth A. Minthorn, Michael G. Darcy, Beth Pietrak
Publikováno v:
Nature Chemical Biology. 10:181-187
Although therapeutic interventions of signal-transduction cascades with targeted kinase inhibitors are a well-established strategy, drug-discovery efforts to identify targeted phosphatase inhibitors have proven challenging. Herein we report a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb71db7b4bb5f997fdb94af3d686a04
https://doi.org/10.1038/nchembio.1427
https://doi.org/10.1038/nchembio.1427
Publikováno v:
Analysis of Protein Post-Translational Modifications by Mass Spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21fac45baf9f10dbdd7cf91359bf90cd
https://doi.org/10.1002/9781119250906.ch2
https://doi.org/10.1002/9781119250906.ch2
Autor:
Michelle C. Schaeffer, Peter J. Gough, James Kang, Viera Kasparcova, Jae U. Jeong, LaShadric C. Grady, Joshua N. Finger, Paris Ward, Daohua Zhang, Robert W. Marquis, Lauren Dare, Michael T. Ouellette, Deepak Bandyopadhyay, Rakesh Nagilla, Xiaoyang Dong, Carol A. Capriotti, Christina S. Pao, Nino Campobasso, Rachel D. Totoritis, Philip A. Harris, Ruth Lehr, Jennifer Summerfield, Bryan W. King, Ami S. Lakdawala, Julie A. Cox, Barbara A. Swift, Aming Zhang, Scott B. Berger, John Bertin, Dean E. McNulty, Alan R. Rendina, Sandra J. Hoffman
Publikováno v:
Journal of medicinal chemistry. 59(5)
The recent discovery of the role of receptor interacting protein 1 (RIP1) kinase in tumor necrosis factor (TNF)-mediated inflammation has led to its emergence as a highly promising target for the treatment of multiple inflammatory diseases. We screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9168ddd779d483ed3d92b7e660ed9cf
https://pubmed.ncbi.nlm.nih.gov/26854747
https://pubmed.ncbi.nlm.nih.gov/26854747