Zobrazeno 1 - 10
of 595
pro vyhledávání: '"Dean D, Metcalfe"'
Autor:
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 4, Pp 100296- (2024)
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators. The most frequent presentation of SM is indolent SM (ISM), with moderate symptoms and p
Externí odkaz:
https://doaj.org/article/7ae7eb01fa14400089442bdc7c6a81fe
Autor:
Andrea J. Luker, Abigail Wukitch, Joseph M. Kulinski, Sundar Ganesan, Juraj Kabat, Justin Lack, Pamela Frischmeyer-Guerrerio, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The successful development of germinal centers (GC) relies heavily on innate mechanisms to amplify the initial inflammatory cascade. In addition to their role in antigen presentation, innate cells are essential for the redirection of circulating lymp
Externí odkaz:
https://doaj.org/article/d8c9be8b0eb9405087e8bc07eb6babcf
Autor:
Vivian Cao, MS, Serena J. Lee, BS, Yun Bai, MS, Steven M. Holland, MD, Lindsey B. Rosen, PhD, Dean D. Metcalfe, MD, MS, Hirsh D. Komarow, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100273- (2024)
Background: Autoantibodies to type I interferons have been identified in association with a variety of inflammatory and autoimmune diseases. Type I interferons have demonstrated inhibitory effects on mast cell proliferation and degranulation. Systemi
Externí odkaz:
https://doaj.org/article/00f84a78f3f3450fa8cd5c61d0f9ecfc
Autor:
Geethani Bandara, Guido H. Falduto, Andrea Luker, Yun Bai, Annika Pfeiffer, Justin Lack, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo. HMC-1.2 cells express constitutively a
Externí odkaz:
https://doaj.org/article/f228152ee4b24e9aa7a9dcf036833746
Autor:
Annika Pfeiffer, Jennifer D. Petersen, Guido H. Falduto, David Eric Anderson, Joshua Zimmerberg, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 10, Pp n/a-n/a (2022)
Abstract Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient
Externí odkaz:
https://doaj.org/article/165c68a2761947fb95bb85c81dfb9874
Autor:
Do-Kyun Kim, Geethani Bandara, Young-Eun Cho, Hirsh D. Komarow, Danielle R. Donahue, Baktiar Karim, Moon-Chang Baek, Ho Min Kim, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when inject
Externí odkaz:
https://doaj.org/article/5187de6573944f56922f41e7869f5c9c
Autor:
Mohammad Fereydouni, Elnaz Ahani, Parth Desai, Mona Motaghed, Anthony Dellinger, Dean D. Metcalfe, Yuzhi Yin, Sung Hyun Lee, Tal Kafri, Aadra P. Bhatt, Kristen Dellinger, Christopher L. Kepley
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The diversity of autologous cells being used and investigated for cancer therapy continues to increase. Mast cells (MCs) are tissue cells that contain a unique set of anti-cancer mediators and are found in and around tumors. We sought to exploit the
Externí odkaz:
https://doaj.org/article/ec9131e22c2148f394335b7e0dd2b751
Autor:
Mohammad Fereydouni, Mona Motaghed, Elnaz Ahani, Tal Kafri, Kristen Dellinger, Dean D. Metcalfe, Christopher L. Kepley
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The emergence of cancer immunotherapies utilizing adoptive cell transfer (ACT) continues to be one of the most promising strategies for cancer treatment. Mast cells (MCs) which occur throughout vascularized tissues, are most commonly associated with
Externí odkaz:
https://doaj.org/article/42e787d787304e2fb93ba17353ad8f01
Autor:
Peter Valent, Cem Akin, Karin Hartmann, Ivan Alvarez-Twose, Knut Brockow, Olivier Hermine, Marek Niedoszytko, Juliana Schwaab, Jonathan J. Lyons, Melody C. Carter, Hanneke Oude Elberink, Joseph H. Butterfield, Tracy I. George, Georg Greiner, Celalettin Ustun, Patrizia Bonadonna, Karl Sotlar, Gunnar Nilsson, Mohamad Jawhar, Frank Siebenhaar, Sigurd Broesby-Olsen, Selim Yavuz, Roberta Zanotti, Magdalena Lange, Boguslaw Nedoszytko, Gregor Hoermann, Mariana Castells, Deepti H. Radia, Javier I. Muñoz-Gonzalez, Wolfgang R. Sperr, Massimo Triggiani, Hanneke C. Kluin-Nelemans, Stephen J. Galli, Lawrence B. Schwartz, Andreas Reiter, Alberto Orfao, Jason Gotlib, Michel Arock, Hans-Peter Horny, Dean D. Metcalfe
Publikováno v:
HemaSphere, Vol 5, Iss 11, p e646 (2021)
Mastocytosis is a hematologic neoplasm characterized by expansion and focal accumulation of neoplastic mast cells (MC) in diverse organs, including the skin, bone marrow (BM), spleen, liver, and gastrointestinal tract. The World Health Organization c
Externí odkaz:
https://doaj.org/article/baa6c70f9bed4d09abd7657782291f35
Autor:
Jack Chovanec, Ilker Tunc, Jason Hughes, Joseph Halstead, Allyson Mateja, Yihui Liu, Michael P. O’Connell, Jiwon Kim, Young Hwan Park, Qinlu Wang, Quang Le, Mehdi Pirooznia, Neil N. Trivedi, Yun Bai, Yuzhi Yin, Amy P. Hsu, Joshua McElwee, Sheryce Lassiter, Celeste Nelson, Judy Bandoh, Thomas DiMaggio, Julij Šelb, Matija Rijavec, Melody C. Carter, Hirsh D. Komarow, Vito Sabato, Joshua Steinberg, Kurt M. Hafer, Elizabeth Feuille, Christopher S. Hourigan, Justin Lack, Paneez Khoury, Irina Maric, Roberta Zanotti, Patrizia Bonadonna, Lawrence B. Schwartz, Joshua D. Milner, Sarah C. Glover, Didier G. Ebo, Peter Korošec, George H. Caughey, Erica H. Brittain, Ben Busby, Dean D. Metcalfe, Jonathan J. Lyons
Publikováno v:
Blood Advances. 7:1796-1810
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where basal serum tryptase (BST) levels >20 ng/mL are a minor criterion for diagnosis. Although clonal myeloid neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b1e16bb80814d45a4331da3200c0782
https://doi.org/10.1182/bloodadvances.2022007936
https://doi.org/10.1182/bloodadvances.2022007936