Zobrazeno 1 - 10
of 18 508
pro vyhledávání: '"Dean D"'
Autor:
Andrea J. Luker, Abigail Wukitch, Joseph M. Kulinski, Sundar Ganesan, Juraj Kabat, Justin Lack, Pamela Frischmeyer-Guerrerio, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The successful development of germinal centers (GC) relies heavily on innate mechanisms to amplify the initial inflammatory cascade. In addition to their role in antigen presentation, innate cells are essential for the redirection of circulating lymp
Externí odkaz:
https://doaj.org/article/d8c9be8b0eb9405087e8bc07eb6babcf
Autor:
Vivian Cao, MS, Serena J. Lee, BS, Yun Bai, MS, Steven M. Holland, MD, Lindsey B. Rosen, PhD, Dean D. Metcalfe, MD, MS, Hirsh D. Komarow, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100273- (2024)
Background: Autoantibodies to type I interferons have been identified in association with a variety of inflammatory and autoimmune diseases. Type I interferons have demonstrated inhibitory effects on mast cell proliferation and degranulation. Systemi
Externí odkaz:
https://doaj.org/article/00f84a78f3f3450fa8cd5c61d0f9ecfc
Autor:
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 4, Pp 100296- (2024)
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators. The most frequent presentation of SM is indolent SM (ISM), with moderate symptoms and p
Externí odkaz:
https://doaj.org/article/7ae7eb01fa14400089442bdc7c6a81fe
Autor:
Dean D Mackenzie, M Anne Naeth
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0306018 (2024)
Reclamation of disturbances from oil sands mining requires effective soil management to ensure successful plant establishment and to promote recovery of native plant communities. In this study we investigated the effects of salvage depths (shallow vs
Externí odkaz:
https://doaj.org/article/49ca4c8e107a49a19b5efa550b20a4b2
Autor:
Geethani Bandara, Guido H. Falduto, Andrea Luker, Yun Bai, Annika Pfeiffer, Justin Lack, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo. HMC-1.2 cells express constitutively a
Externí odkaz:
https://doaj.org/article/f228152ee4b24e9aa7a9dcf036833746
Autor:
Sophia M. Becker, Trenton E. Franz, Olufemi Abimbola, Dean D. Steele, J. Paulo Flores, Xinhua Jia, Thomas F. Scherer, Daran R. Rudnick, Christopher M. U. Neale
Publikováno v:
Vadose Zone Journal, Vol 21, Iss 6, Pp n/a-n/a (2022)
Abstract A study was conducted at three sites in North Dakota to strengthen understanding of the usefulness of different proximal geophysical data types in agricultural contexts of varying pedology. This study hypothesizes that electromagnetic induct
Externí odkaz:
https://doaj.org/article/a619488e178a4f8f9ec15788cd17b3df
Autor:
Annika Pfeiffer, Jennifer D. Petersen, Guido H. Falduto, David Eric Anderson, Joshua Zimmerberg, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 10, Pp n/a-n/a (2022)
Abstract Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient
Externí odkaz:
https://doaj.org/article/165c68a2761947fb95bb85c81dfb9874
Autor:
Do-Kyun Kim, Geethani Bandara, Young-Eun Cho, Hirsh D. Komarow, Danielle R. Donahue, Baktiar Karim, Moon-Chang Baek, Ho Min Kim, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when inject
Externí odkaz:
https://doaj.org/article/5187de6573944f56922f41e7869f5c9c
Autor:
Mohammad Fereydouni, Elnaz Ahani, Parth Desai, Mona Motaghed, Anthony Dellinger, Dean D. Metcalfe, Yuzhi Yin, Sung Hyun Lee, Tal Kafri, Aadra P. Bhatt, Kristen Dellinger, Christopher L. Kepley
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The diversity of autologous cells being used and investigated for cancer therapy continues to increase. Mast cells (MCs) are tissue cells that contain a unique set of anti-cancer mediators and are found in and around tumors. We sought to exploit the
Externí odkaz:
https://doaj.org/article/ec9131e22c2148f394335b7e0dd2b751
Autor:
Mohammad Fereydouni, Mona Motaghed, Elnaz Ahani, Tal Kafri, Kristen Dellinger, Dean D. Metcalfe, Christopher L. Kepley
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The emergence of cancer immunotherapies utilizing adoptive cell transfer (ACT) continues to be one of the most promising strategies for cancer treatment. Mast cells (MCs) which occur throughout vascularized tissues, are most commonly associated with
Externí odkaz:
https://doaj.org/article/42e787d787304e2fb93ba17353ad8f01