Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Dean C. Luehrs"'
Autor:
John Lopez, Tyler A. Kokjohn, Alex E. Roher, Ian D. Daugs, Lucia I. Sue, Dean C. Luehrs, Jesse M. Hunter, Walter M. Kalback, Eduardo M. Castaño, Thomas G. Beach, Gregory D. Van Vickle, Chera L. Maarouf, Daniel C. Brune
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812:1508-1514
Amyloid-β (Aβ) peptides are intimately involved in the inflammatory pathology of atherosclerotic vascular disease (AVD) and Alzheimer's disease (AD). Although substantial amounts of these peptides are produced in the periphery, their role and signi
Autor:
Dean C. Luehrs, Chera Esh, Thomas G. Beach, Walter M. Kalback, Douglas G. Walker, Eduardo M. Castaño, Alex E. Roher, Judianne Davis, Gregory D. Van Vickle, Lih-Fen Lue, Ian D. Daugs, Tyler A. Kokjohn, William E. Van Nostrand, R. Lyle Patton
Publikováno v:
The American Journal of Pathology. 173:483-493
Alzheimer's disease (AD) is characterized by the accumulation of extracellular insoluble amyloid, primarily derived from polymerized amyloid-beta (Abeta) peptides. We characterized the chemical composition of the Abeta peptides deposited in the brain
Autor:
Marissa Poston, Frederick G Fifield, Walter M. Kalback, Tyler A Kokjohn, Chera L Esh, Alex E Roher, Gregory D. Van Vickle, Daniel C. Brune, Dean C. Luehrs, R. Lyle Patton, Amanda J. Newel, David Westaway, Thomas G. Beach, Joanne McLaurin, John Lopez, Paul E Fraser
Publikováno v:
Biochemistry. 46:10317-10327
We investigated the morphology and biochemistry of the amyloid-beta (Abeta) peptides produced in TgCRND8 Tg mice carrying combined amyloid precursor protein (APP) Swedish (K670M/N671L) and Indiana (V717F) mutations. Histological analyses employing am
Autor:
Eliezer Masliah, Daniel C. Brune, Eduardo M. Castaño, Thomas G. Beach, Amanda J. Newel, Alex E. Roher, Gregory D. Van Vickle, Dean C. Luehrs, Tyler A. Kokjohn, John Lopez, Yu Min Kuo, Walter M. Kalback, Chera Esh, Isidro Ferrer, R. Lyle Patton
Publikováno v:
The American Journal of Pathology. 169:1048-1063
Experiments with amyloid-β (Aβ)-42-immunized transgenic mouse models of Alzheimer's disease have revealed amyloid plaque disruption and apparent cognitive function recovery. Neuropathological examination of patients vaccinated against purified Aβ-
Autor:
Yu Min Kuo, David M. Stern, W. Blaine Stine, Ann Marie Schmidt, Alex E. Roher, Shi Du Yan, Michael O. Chaney, Dean C. Luehrs, Chera Esh, Afroza Rahman, Tyler A. Kokjohn
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1741(1-2):199-205
In the AD brain, there are elevated amounts of soluble and insoluble Abeta peptides which enhance the expression of membrane bound and soluble receptor for advanced glycation end products (RAGE). The binding of soluble Abeta to soluble RAGE inhibits
Autor:
Dean C. Luehrs, Eduardo M. Castaño, Alex E. Roher, Lucia I. Sue, Francoise Gerber, Douglas G. Walker, Bernd Bohrmann, Chera Esh, Thomas G. Beach, Walter M. Kalback, Tyler A. Kokjohn, Afroza Rahman, Claudia Richardson, Raquel Cisneros
Publikováno v:
Neurological Research. 26:525-539
We postulate that severe atherosclerotic occlusion of the circle of Willis and leptomeningeal arteries is an important factor in the pathogenesis of some sporadic Alzheimer's disease (AD) cases. These arterial stenoses are complicated by an overwhelm
Autor:
Jennifer Childress, Ruben Vidal, Daniel C. Brune, Alex E. Roher, Dean C. Luehrs, Jill R. Murrell, Tyler A. Kokjohn, John Lopez, Chera Esh, Yu Min Kuo, Walter M. Kalback, Nicole Weiss, Bernardino Ghetti, Martin R. Farlow
Publikováno v:
Journal of Biological Chemistry. 279:5829-5836
One of the familial forms of Alzheimer's disease (AD) encodes the amyloid-beta precursor protein (AbetaPP) substitution mutation V717F. This mutation is relevant to AD research, since it has been utilized to generate transgenic mice models to study A
Autor:
Walter M. Kalback, Tyler A. Kokjohn, Thomas G. Beach, Alex E. Roher, James D. Seward, Chera Esh, Dean C. Luehrs, Lucia I. Sue
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:2055-2062
Objectives— We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer’s disease (AD). Methods and Results— Fifty-four consecutive autopsy cases, 32 AD and 22 nondemented contro
Autor:
Michael O. Chaney, Dean C. Luehrs, Tyler A. Kokjohn, Alex E. Roher, Jennifer Childress, Chera Esh, Jerome Baudry
Publikováno v:
Neurological Research. 25:581-589
In this paper we explore the potential functional role of the A beta peptides in the context of Alzheimer's disease (AD). We begin by defining the morphology of the amyloid deposits in relation to surrounding glial cells and, more importantly, in rel
Autor:
Thomas G. Beach, Tyler A. Kokjohn, Alex E. Roher, Carmen Knebel, Yu Min Kuo, Walter M. Kalback, Dean C. Luehrs, Nicole Weiss, Chera Esh, Jennifer Childress, Roy O. Weller
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
Alzheimer’s disease (AD) is characterized by neurofibrillary tangles and by the accumulation of β-amyloid (Aβ) peptides in senile plaques and in the walls of cortical and leptomeningeal arteries as cerebral amyloid angiopathy (CAA). There also is