Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Dean C, Singleton"'
Autor:
Tet Woo Lee, Dean C. Singleton, Julia K. Harms, Man Lu, Sarah P. McManaway, Amy Lai, Moana Tercel, Frederik B. Pruijn, Andrew M. J. Macann, Francis W. Hunter, William R. Wilson, Stephen M. F. Jamieson
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1885-1903 (2024)
Tumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head and neck squamous cell carcinoma (HNSCC). To effectively target hypoxia, therapies require selection biomarkers and preclinical models that can accurately model
Externí odkaz:
https://doaj.org/article/8463ca23a4994262a7d8bf8b809ac374
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 3, Pp 297-320 (2022)
The development of endocrine resistance is a common reason for the failure of endocrine therapies in hormone receptor-positive breast cancer. This review provides an overview of the different types of in vitro models that have been developed as tools
Externí odkaz:
https://doaj.org/article/9fda8b6e94c341e9848e2e33c8f69877
Autor:
Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley, Euphemia Y. Leung
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutaminase. This glutamate h
Externí odkaz:
https://doaj.org/article/610f5156d2c24e1e8f92504261190da4
Autor:
Euphemia Y. Leung, Marjan E. Askarian-Amiri, Dean C. Singleton, Carole Ferraro-Peyret, Wayne R. Joseph, Graeme J. Finlay, Reuben J. Broom, Purvi M. Kakadia, Stefan K. Bohlander, Elaine Marshall, Bruce C. Baguley
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Background: Most human breast cancer cell lines currently in use were developed and are cultured under ambient (21%) oxygen conditions. While this is convenient in practical terms, higher ambient oxygen could increase oxygen radical production, poten
Externí odkaz:
https://doaj.org/article/8fe0484eac0b4e098934e7c44d3dace8
Autor:
Dean C. Singleton, Sophie P. Syddall, Amir Ashoorzadeh, Alexandra M. Mowday, Dan Li, Jeff B. Smaill, Christopher P. Guise, Sally Y. Bai, William R. Wilson, Adam V. Patterson
Publikováno v:
Cancer Gene Therapy. 29:1021-1032
Advances in the field of cancer immunotherapy have stimulated renewed interest in adenoviruses as oncolytic agents. Clinical experience has shown that oncolytic adenoviruses are safe and well tolerated but possess modest single-agent activity. One ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b27638279eb5fc7da46196d6b720e6e2
https://doi.org/10.1038/s41417-021-00409-2
https://doi.org/10.1038/s41417-021-00409-2
Autor:
Cherie Blenkiron, Stefan K. Bohlander, Maggie L. Kalev-Zylinska, Nicholas Knowlton, Taryn N. Green, Raewyn C. Poulsen, James I. Hearn, Yohanes Nursalim, Leandro Ladvanszky, Dean C. Singleton, Martin Chopra
Publikováno v:
Thrombosis and Haemostasis
The release of calcium ions (Ca2+) from the endoplasmic reticulum (ER) and related store-operated calcium entry (SOCE) regulate maturation of normal megakaryocytes. The N-methyl-D-aspartate (NMDA) receptor (NMDAR) provides an additional mechanism for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17470336f2557e91e4626c257365d60
https://doi.org/10.1055/s-0040-1708483
https://doi.org/10.1055/s-0040-1708483
Publikováno v:
Molecules, Vol 14, Iss 11, Pp 4517-4545 (2009)
Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert nontoxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to
Externí odkaz:
https://doaj.org/article/3b90ff071cfa4179ab022d6f78a0efe6
Publikováno v:
Nature reviews. Clinical oncology. 18(12)
Hypoxia is prevalent in human tumours and contributes to microenvironments that shape cancer evolution and adversely affect therapeutic outcomes. Historically, two different tumour microenvironment (TME) research communities have been discernible. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fda359de8cbf2c058be852e9074d0ea2
https://pubmed.ncbi.nlm.nih.gov/34326502
https://pubmed.ncbi.nlm.nih.gov/34326502
Autor:
Dean C. Singleton, Lydia P. Liew, Stephen M. F. Jamieson, Michael P. Hay, Way W. Wong, Gary J. Cheng
Publikováno v:
Chemistry – An Asian Journal. 14:1238-1248
Tumour hypoxia plays an important role in tumour progression and resistance to therapy. Under hypoxia unfolded proteins accumulate in the endoplasmic reticulum (ER) and this stress is relieved through the protein kinase R-like ER kinase (PERK) signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c55032aba59c44a25ed978ab600dad5
https://doi.org/10.1002/asia.201801826
https://doi.org/10.1002/asia.201801826
Autor:
William P. Katt, Pamela M. Murray, Dean C. Singleton, Bruce C. Baguley, Euphemia Leung, Anne-Lise Dechaume
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
BMC Cancer
BMC Cancer
Background Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutaminase. This glutamate has many u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d440071e483fd65a5784171fe5eee657
https://doi.org/10.21203/rs.2.24648/v3
https://doi.org/10.21203/rs.2.24648/v3
