Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Dean C, Ripple"'
Autor:
Minkyung Kim, Youlong Ma, Charudharshini Srinivasan, Thomas O’Connor, Srivalli N. Telikepalli, Dean C. Ripple, Scott Lute, Ashwinkumar Bhirde
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Subvisible particles (SVPs) are a critical quality attribute of injectable therapeutic proteins (TPs) that needs to be controlled due to potential risks associated with drug product quality. The current compendial methods routinely used to a
Externí odkaz:
https://doaj.org/article/59fedfcc14744d30b6b9e3712346a229
Autor:
Paul C. DeRose, Kurt D. Benkstein, Elzafir B. Elsheikh, Adolfas K. Gaigalas, Sean E. Lehman, Dean C. Ripple, Linhua Tian, Wyatt N. Vreeland, Eric J. Welch, Adam W. York, Yu-Zhong Zhang, Lili Wang
Publikováno v:
Nanomaterials, Vol 12, Iss 18, p 3118 (2022)
The number of techniques to measure number concentrations and size distributions of submicrometer particles has recently increased. Submicrometer particle standards are needed to improve the accuracy and reproducibility of these techniques. The numbe
Externí odkaz:
https://doaj.org/article/eb99cd50975d40c6841899f7eec8c556
Autor:
Christopher P. Calderon, Dean C. Ripple, Charudharshini Srinivasan, Youlong Ma, Michael J. Carrier, Theodore W. Randolph, Thomas F. O’Connor
Publikováno v:
Pharmaceutical Research. 39:263-279
Autor:
Srivalli N, Telikepalli, Michael J, Carrier, Dean C, Ripple, Greg, Barnett, Ashwinkumar, Bhirde, Donna, Bolton, George M, Bou-Assaf, Erica, Ferrari, Scott, Leigh, Sophia, Levitskaya-Seaman, Tim, Menzen, Felix, Nikels, Anna, Riley, Miguel, Saggu, Neha, Sahni, Eric, Vernooij, Klaus, Wuchner
Publikováno v:
AAPS PharmSciTech. 24
Visible protein-like particle standards may improve visual inspection and/or appearance testing practices used in the biotechnology industry. They may improve assay performance resulting in better alignment and more standardized training among differ
Autor:
Dean C. Ripple, Richard E. Cavicchi
Publikováno v:
Journal of Pharmaceutical Sciences. 109:488-495
Dynamic imaging analysis instruments are used for sizing particles of different types that might appear in a biopharmaceutical. These instruments are calibrated using polystyrene latex microspheres in water, which is a significantly different system
Publikováno v:
Journal of Industrial Microbiology & Biotechnology
Online water bioburden analyzers (OWBAs) can provide real-time feedback on viable bacteria in high-purity water (HPW) systems for pharmaceutical manufacturers. To calibrate and validate OWBAs, which detect bacteria using scattered light and bacterial
Autor:
Franziska Schleinzer, Dennis T. Yang, Dean C. Ripple, Nazar Filonov, Pascal Chalus, Tapan K. Das, Kurt D. Benkstein, Ashwinkumar A. Bhirde, Stefan Romeijn, Fook Chiong Cheong, Sambit R. Kar, Laura A. Philips, Christine Probst, Adam D. Grabarek, Nicole S. Gill, Maciej Jarzebski, Yoen Joo Kim, David L. Duewer, Miguel Saggu, Andrew D. Hollingsworth, Gurusamy Balakrishnan, Judith Hadley, Vikram Kestens, Yannic Ramaye, Anja Matter, Wesley W. Howard, Theodore W. Randolph, Ngoc Do, Jan Kuba Tatarkiewicz, David G. Grier, Heather Anne Wright, Patrick Garidel, Atanas Koulov, Wim Jiskoot, Jared R. Snell, Harshit Khasa
Publikováno v:
J Pharm Sci
Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences
The measurement of polydisperse protein aggregates and particles in biotherapeutics remains a challenge, especially for particles with diameters of ≈ 1 µm and below (sub-micrometer). This paper describes an interlaboratory comparison with the goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebec099deb60130fdbf19d1d6774ab17
https://europepmc.org/articles/PMC9912188/
https://europepmc.org/articles/PMC9912188/
Autor:
Christopher P, Calderon, Dean C, Ripple, Charudharshini, Srinivasan, Youlong, Ma, Michael J, Carrier, Theodore W, Randolph, Thomas F, O'Connor
Publikováno v:
Pharmaceutical research. 39(2)
Digital microscopy is used to monitor particulates such as protein aggregates within biopharmaceutical products. The images that result encode a wealth of information that is underutilized in pharmaceutical process monitoring. For example, images of
Publikováno v:
Journal of Pharmaceutical Sciences. 107:1383-1391
Nanoparticle tracking analysis (NTA) obtains particle size by analysis of particle diffusion through a time series of micrographs and particle count by a count of imaged particles. The number of observed particles imaged is controlled by the scatteri