Gut IgA Enhances Systemic IgG Responses to Pneumococcal Vaccines Through the Commensal Microbiota

Autor: García Prat M, Charlotte Cunningham-Rundles, Emilie K. Grasset, Giuliana Magri, Cindy Gutzeit, Paul J. Maglione, Pybus M, Martín Nalda A, Dieli-Crimi R, Lewis Tomalin, Tejedor Vaquero S, Tachó-Piñot R, Graham J. Britton, Martinez Gallo M, Suarez-Farina M, Andrea Cerutti, Saurabh Mehandru, Jose C. Clemente, Veeramreddy Pk, Jeremiah J. Faith, Dean B. Matthews

SUMMARYThe gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines. However, it is unknown whether this effect involves IgA, a mucosal antibody that coats intestinal microbes. Here we found that gut IgA increased peripheral IgG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ecceb1a4f775757ba1523fa3a1c1703
https://doi.org/10.1101/2021.04.29.439534

Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells

Autor: Mathieu Uzzan, Michael A. Oropallo, Saurabh Mehandru, Meera Ramanujam, Jordi Sintes, Zhengxiang He, Giuliana Magri, Oliver Pabst, I. Thomsen, Gerold Bongers, Veeramreddy Pk, S. Casas-Recasens, Dean B. Matthews, Arthur Mortha, Andrea Cerutti, Cindy Gutzeit, Alejo Chorny, Paul J. Maglione, Charlotte Cunningham-Rundles, Bernardo S. Reis, Lili Chen, Jorge Carrillo, Richard J. Bram, Jeremiah J. Faith, Emilie K. Grasset

Publikováno v: Science Immunology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)
Sci Immunol

The gut mounts secretory immunoglobulin A (SIgA) responses to commensal bacteria through nonredundant T cell-dependent (TD) and T cell-independent (TI) pathways that promote the establishment of mutualistic host-microbiota interactions. SIgAs from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4bee7dda052b95004002275f41f9fb
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1182

Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44

Autor: David Artis, Laura Comerma, A. Cooper Walland, Andrea Cerutti, Willem van de Veen, Meimei Shan, Hugh A. Sampson, Bing He, Tadech Boonpiyathad, John R. Yeiser, Emilie K. Grasset, Kang Chen, Ada Yeste, Lisa C. Osborne, Daniel Segura-Garzón, Marc Pybus, Saurabh Mehandru, Mark C. Siracusa, M. Cecilia Berin, Dean B. Matthews, Jorge Carrillo, Cindy Gutzeit, Haekyung Lee, Mübeccel Akdis, Julià Blanco

Publikováno v: Immunity
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Summary B cells thwart antigenic aggressions by releasing immunoglobulin M (IgM), IgG, IgA, and IgE, which deploy well-understood effector functions. In contrast, the role of secreted IgD remains mysterious. We found that some B cells generated IgD-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccf30e3b9ec72c192e6af0127f5e787
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5415

Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity

Autor: Seth D. Reighard, Stephen A. K. Harvey, William A. LaFramboise, Rodolfo D. Vicetti Miguel, Dean B. Matthews, Thomas L. Cherpes

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58565 (2013)
PLoS ONE

While Chlamydia trachomatis infections are frequently asymptomatic, mechanisms that regulate host response to this intracellular Gram-negative bacterium remain undefined. This investigation thus used peripheral blood mononuclear cells and endometrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79febf320c2778d4eaea120d543bf4ec
http://europepmc.org/articles/PMC3603585?pdf=render