Zobrazeno 1 - 10
of 436
pro vyhledávání: '"Dean A. Lee"'
Autor:
Wen Luo, Hai Hoang, Katherine E. Miller, Hongwen Zhu, Serena Xu, Xiaokui Mo, Elizabeth A. R. Garfinkle, Heather Costello, Saranga Wijeratne, Wiebke Chemnitz, Ronan Gandhi, Yanling Liao, Janet Ayello, Aliza Gardenswartz, Jeremy M. Rosenblum, Kevin A. Cassady, Elaine R. Mardis, Dean A. Lee, Timothy P. Cripe, Mitchell S. Cairo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES), we found that tumo
Externí odkaz:
https://doaj.org/article/ef612054309d4f2fb16fbb5249bba11b
Autor:
Emily M. Ringwalt, Mark A. Currier, Andrea M. Glaspell, Chun-Yu Chen, Matthew V. Cannon, Maren Cam, Amy C. Gross, Matthew Gust, Pin-Yi Wang, Louis Boon, Laura E. Biederman, Emily Schwarz, Prajwal Rajappa, Dean A. Lee, Elaine R. Mardis, William E. Carson, 3rd, Ryan D. Roberts, Timothy P. Cripe
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200886- (2024)
We previously reported that the DNA alkylator and transcriptional-blocking chemotherapeutic agent trabectedin enhances oncolytic herpes simplex viroimmunotherapy in human sarcoma xenograft models, though the mechanism remained to be elucidated. Here
Externí odkaz:
https://doaj.org/article/9f97543ab8ef4ba1b69298b70f6f6188
Autor:
Joseph A. Mamola, Chun-Yu Chen, Mark A. Currier, Kevin Cassady, Dean A. Lee, Timothy P. Cripe
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 118-124 (2023)
The use of oncolytic viruses (OVs) and adoptive cell therapies (ACT) have independently emerged as promising approaches for cancer immunotherapy. More recently, the combination of such agents to obtain a synergistic anticancer effect has gained atten
Externí odkaz:
https://doaj.org/article/6e5e3ef423954cc8a6709b96845317d9
Autor:
Joseph R. Caporale, Dean A. Lee
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/60fb25bfc7c044dfa176b74bc544ed66
Autor:
Jessica Encinas, Almudena García-Ortiz, Elena Maroto-Martín, Eva Castellano, Raquel Oliva, Rafael Alonso Fernández, Maria Teresa Cedena Romero, Alejandra Leivas, Beatriz Martín-Antonio, Guillermo Suñe, Dean A. Lee, Daniel J. Powell, Jr., Paula Río, Joaquín Martinez-Lopez, Antonio Valeri
Publikováno v:
HemaSphere, Vol 7, p e16745e9 (2023)
Externí odkaz:
https://doaj.org/article/b37aaf58a48b40bfaa7cf51be3e79589
Autor:
Payal Aggarwal, Wen Luo, Katherine C. Pehlivan, Hai Hoang, Prajwal Rajappa, Timothy P. Cripe, Kevin A. Cassady, Dean A. Lee, Mitchell S. Cairo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
High grade gliomas are identified as malignant central nervous tumors that spread rapidly and have a universally poor prognosis. Historically high grade gliomas in the pediatric population have been treated similarly to adult high grade gliomas. For
Externí odkaz:
https://doaj.org/article/59aa2ba0d016490c89b1120c5578edcc
Autor:
Alejandra Leivas, Antonio Valeri, Laura Córdoba, Almudena García-Ortiz, Alejandra Ortiz, Laura Sánchez-Vega, Osvaldo Graña-Castro, Lucía Fernández, Gonzalo Carreño-Tarragona, Manuel Pérez, Diego Megías, María Liz Paciello, Jose Sánchez-Pina, Antonio Pérez-Martínez, Dean A. Lee, Daniel J. Powell, Paula Río, Joaquín Martínez-López
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 8, Pp 1-11 (2021)
Abstract CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when redirected against resistant myeloma cells. CARs can be designed through the use of receptors, su
Externí odkaz:
https://doaj.org/article/1628f0cb7aff4d6990b48e1fdfb3acb4
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide range of malignancies, most not
Externí odkaz:
https://doaj.org/article/9ca33b7b7c014e85a07ebd899d4cbefa
Autor:
Ezgi Elmas, Noushin Saljoughian, Marcelo de Souza Fernandes Pereira, Brian P. Tullius, Kinnari Sorathia, Robin J. Nakkula, Dean A. Lee, Meisam Naeimi Kararoudi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Antitumor activity of immune cells such as T cells and NK cells has made them auspicious therapeutic regimens for adaptive cancer immunotherapy. Enhancing their cytotoxic effects against malignancies and overcoming their suppression in tumor microenv
Externí odkaz:
https://doaj.org/article/790d417c9d5a46eeac12a7c7b8adf566
Autor:
Meisam Naeimi Kararoudi, Alfahdah Alsudayri, Cynthia L. Hill, Ezgi Elmas, Yasemin Sezgin, Aarohi Thakkar, Mark E. Hester, Daniel T. Malleske, Dean A. Lee, Matthew L. Neal, Mark R. Perry, Jill A. Harvilchuck, Susan D. Reynolds
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Respiratory system damage is the primary cause of mortality in individuals who are exposed to vesicating agents including sulfur mustard (SM). Despite these devastating health complications, there are no fielded therapeutics that are specific for suc
Externí odkaz:
https://doaj.org/article/6111819b0f364180ad5dd6f223c4f700