Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Dean A. Le"'
Autor:
Wen Luo, Hai Hoang, Katherine E. Miller, Hongwen Zhu, Serena Xu, Xiaokui Mo, Elizabeth A. R. Garfinkle, Heather Costello, Saranga Wijeratne, Wiebke Chemnitz, Ronan Gandhi, Yanling Liao, Janet Ayello, Aliza Gardenswartz, Jeremy M. Rosenblum, Kevin A. Cassady, Elaine R. Mardis, Dean A. Lee, Timothy P. Cripe, Mitchell S. Cairo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES), we found that tumo
Externí odkaz:
https://doaj.org/article/ef612054309d4f2fb16fbb5249bba11b
Autor:
Emily M. Ringwalt, Mark A. Currier, Andrea M. Glaspell, Chun-Yu Chen, Matthew V. Cannon, Maren Cam, Amy C. Gross, Matthew Gust, Pin-Yi Wang, Louis Boon, Laura E. Biederman, Emily Schwarz, Prajwal Rajappa, Dean A. Lee, Elaine R. Mardis, William E. Carson, 3rd, Ryan D. Roberts, Timothy P. Cripe
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200886- (2024)
We previously reported that the DNA alkylator and transcriptional-blocking chemotherapeutic agent trabectedin enhances oncolytic herpes simplex viroimmunotherapy in human sarcoma xenograft models, though the mechanism remained to be elucidated. Here
Externí odkaz:
https://doaj.org/article/9f97543ab8ef4ba1b69298b70f6f6188
Autor:
Yaya Chu, Gaurav Nayyar, Meijuan Tian, Dean A. Lee, Mehmet F. Ozkaynak, Jessica Ayala-Cuesta, Kayleigh Klose, Keira Foley, Alyssa S. Mendelowitz, Wen Luo, Yanling Liao, Janet Ayello, Gregory K. Behbehani, Stanley Riddell, Timothy P. Cripe, Mitchell S. Cairo
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 2, Pp 200820- (2024)
The prognosis for children with recurrent and/or refractory neuroblastoma (NB) is dismal. The receptor tyrosine kinase-like orphan receptor 1 (ROR1), which is highly expressed on the surface of NB cells, provides a potential target for novel immunoth
Externí odkaz:
https://doaj.org/article/2644140197174223981934890cc1a2e8
Autor:
Joseph A. Mamola, Chun-Yu Chen, Mark A. Currier, Kevin Cassady, Dean A. Lee, Timothy P. Cripe
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 118-124 (2023)
The use of oncolytic viruses (OVs) and adoptive cell therapies (ACT) have independently emerged as promising approaches for cancer immunotherapy. More recently, the combination of such agents to obtain a synergistic anticancer effect has gained atten
Externí odkaz:
https://doaj.org/article/6e5e3ef423954cc8a6709b96845317d9
Autor:
Joseph R. Caporale, Dean A. Lee
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/60fb25bfc7c044dfa176b74bc544ed66
Autor:
Jessica Encinas, Almudena García-Ortiz, Elena Maroto-Martín, Eva Castellano, Raquel Oliva, Rafael Alonso Fernández, Maria Teresa Cedena Romero, Alejandra Leivas, Beatriz Martín-Antonio, Guillermo Suñe, Dean A. Lee, Daniel J. Powell, Jr., Paula Río, Joaquín Martinez-Lopez, Antonio Valeri
Publikováno v:
HemaSphere, Vol 7, p e16745e9 (2023)
Externí odkaz:
https://doaj.org/article/b37aaf58a48b40bfaa7cf51be3e79589
Autor:
Menguy, Eva, Dumontet, Vincent, Coulombier, Noémie, Meriot, Vincent, Déan, Loïc Le, Barthelemy, Vanille, Jauffrais, Thierry
Publikováno v:
In MethodsX 2020 7
Publikováno v:
International Congress Series. 1252:155-161
Programmed or apoptotic-like cell death plays an important role in cell demise following ischemic or traumatic brain injury. Caspases -1, -3, -8, and -11, the pro-death bcl-2 family member BID, and the Fas death receptor have been implicated. We rece
Autor:
Dean A. Le, Sunu S. Thomas, Nikolaus Plesnila, Sepideh Amin-Hanjani, Stanley J. Korsmeyer, Sandra S. Zinkel, Michael A. Moskowitz, Jianhua Qiu, Daniel S. Kohane, Alberto Chiarugi, Yonqin Wu
Publikováno v:
Proceedings of the National Academy of Sciences. 98:15318-15323
Mitochondria and cytochrome c release play a role in the death of neurons and glia after cerebral ischemia. In the present study, we investigated whether BID, a proapoptotic promoter of cytochrome c release and caspase 8 substrate, was expressed in b
Publikováno v:
European Journal of Pharmacology. 375:115-120
Excessive accumulation of glutamate or other excitatory amino acids and the subsequent overactivity of NMDA receptors is currently thought to lead to neuronal injury in cerebral ischemia. Therefore, antagonists of the NMDA receptor may offer an appro