Výsledky vyhledávání - "Dean A. Kirby"

Somatostatin Receptor 1 Selective Analogues: 3. Dicyclic Peptides

Autor: Renzo Cescato, Beatrice Waser, Jean E. F. Rivier, Dean A Kirby, Véronique Eltschinger, Judit Erchegyi, Jean Claude Reubi

Publikováno v: Journal of Medicinal Chemistry. 48:515-522

The binding affinity of short chain somatostatin (SRIF) analogues at the five human SRIF receptors (sst) was determined to identify sterically constrained somatostatin receptor subtype 1 (sst(1)) selective scaffolds. Des-AA(1,2,4,13)-[d-Trp(8)]SRIF (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375421dd8c8d1b4c01467f846fbea2b9
https://doi.org/10.1021/jm049519m

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Potent and Long-Acting Corticotropin Releasing Factor (CRF) Receptor 2 Selective Peptide Competitive Antagonists

Autor: Wylie Vale, Jean Claude Reubi, J. Gulyas, Lei Wang, Dean A. Kirby, V Martinez, Marilyn H. Perrin, Steven C. Koerber, Jean Rivier, William Low, Koichi S. Kunitake, Beatrice Waser, Michael R. DiGruccio, Yvette Taché, Joan Vaughan

Publikováno v: Journal of Medicinal Chemistry. 45:4737-4747

We present evidence that members of the corticotropin releasing factor (CRF) family assume distinct structures when interacting with the CRF(1) and CRF(2) receptors. Predictive methods, physicochemical measurements, and structure-activity relationshi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82352efe2c82c0e1f602a55c9cd5b1f
https://doi.org/10.1021/jm0202122

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Characterization of Betidamino Acid-Containing Somatostatin and Gonadotropin-Releasing Hormone Analogs with Electrospray Mass Spectrometry and Tandem Mass Spectrometry

Autor: Jean Rivier, Guangcheng Jiang, Dean A. Kirby, Steven C. Koerber, Ryan DeBoard, A. Grey Craig

Publikováno v: European Journal of Mass Spectrometry. 7:259-266

We report the electrospray mass spectra and tandem mass (MS/MS) spectra of a series of chemically-stable somatostatin (SRIF) and gonadotropin-releasing hormone (GnRH) analogs which incorporate acylated or alkylated/acylated aminoglycine residues (bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b39fcfb5b6e47bf64fc578375f88562e
https://doi.org/10.1255/ejms.436

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Design of Potent Dicyclic (1−5/4−10) Gonadotropin Releasing Hormone (GnRH) Antagonists

Autor: Struthers Rs, Catherine Rivier, A. G. Craig, Jean Rivier, Guangcheng Jiang, Dean A. Kirby, Laura A. Cervini, S. C. Koerber, John B. Porter

Publikováno v: Journal of Medicinal Chemistry. 43:807-818

In three earlier papers, the structures and biological potencies of numerous mono- and dicyclic antagonists of GnRH were reported. Among these, two families, each containing two to four members were identified that had very high antagonist potencies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57641cb5dd57c8291421aae94e5c665a
https://doi.org/10.1021/jm990116+

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Constrained Corticotropin Releasing Factor Antagonists (Astressin Analogues) with Long Duration of Action in the Rat

Autor: Dean A. Kirby, Catherine Rivier, Anne Z. Corrigan, Wylie Vale, Jean Rivier, S L Lahrichi

Publikováno v: Journal of Medicinal Chemistry. 42:3175-3182

In an earlier report we identified specific modifications and substitutions of corticotropin releasing factor (CRF) that led to the discovery of antagonists with extended duration of action as compared to that of astressin {cyclo(30-33)[DPhe(12),Nle(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af07011f8e7067277b16badf38c2cfb
https://doi.org/10.1021/jm9902133

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Anxiolytic activity of NPY receptor agonists in the conflict test

Autor: Dean A. Kirby, S. Southerland, Karen T. Britton, E. Van Uden, George F. Koob, Jean Rivier

Publikováno v: Psychopharmacology. 132:6-13

This investigation examined receptor subtype specificity and possible modulation by GABAa receptor ligands of NPY-induced behavioral responses to stressful stimuli. First, a series of NPY receptor agonists were examined for their potential effects on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddbcbb69694fb7b859feeb09b4b7c8c
https://doi.org/10.1007/s002130050313

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Separation of neuropeptide Y diastereomers by high-performance liquid chromatography and capillary zone electrophoresis

Autor: Charleen Miller, Dean A. Kirby, Jean Rivier

Publikováno v: Journal of Chromatography A. 648:257-265

Separation of analogues of neuropeptide Y (NPY) in which a single d -amino acid replaced the corresponding naturally occurring residue was performed by chromatographic techniques to ensure the quality of the synthetic peptides to be used for structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa306a514f2c79b1a8132d055ab5d49
https://doi.org/10.1016/0021-9673(93)83309-g

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Defining structural requirements for neuropeptide Y receptors using truncated and conformationally restricted analogs

Autor: Dean A. Kirby, S. C. Koerber, Jean Rivier, A. G. Craig, R. D. Feinstein, L. Delmas, Marvin R. Brown

Publikováno v: Journal of Medicinal Chemistry. 36:385-393

To further elucidate the minimum bioactive conformation of neuropeptide Y (NPY), a series of truncated and conformationally constrained analogues has been prepared. The synthesis and purification of these peptides was achieved using routine laborator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1b7aa4b2cae495eba4ec1e5c2da41b
https://doi.org/10.1021/jm00055a010

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