Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Dean A Jackson"'
Autor:
John M Ankers, Raheela Awais, Nicholas A Jones, James Boyd, Sheila Ryan, Antony D Adamson, Claire V Harper, Lloyd Bridge, David G Spiller, Dean A Jackson, Pawel Paszek, Violaine Sée, Michael RH White
Publikováno v:
eLife, Vol 5 (2016)
Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are prioritised di
Externí odkaz:
https://doaj.org/article/c93dc22ec0694d76b838a26b6974d89e
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77015 (2013)
Induction of genes is rarely an isolated event; more typically occurring as part of a web of parallel interactions, or motifs, which act to refine and control gene expression. Here, we define an Incoherent Feed-forward Loop motif in which TNFα-induc
Externí odkaz:
https://doaj.org/article/80019ac242d04425bf24a7d984350f62
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27527 (2011)
The distribution of chromatin within the mammalian nucleus is constrained by its organization into chromosome territories (CTs). However, recent studies have suggested that promiscuous intra- and inter-chromosomal interactions play fundamental roles
Externí odkaz:
https://doaj.org/article/c11f9fddfdc4403a817b5d59cc238b9d
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000900 (2010)
DNA synthesis must be performed with extreme precision to maintain genomic integrity. In mammalian cells, different genomic regions are replicated at defined times, perhaps to preserve epigenetic information and cell differentiation status. However,
Externí odkaz:
https://doaj.org/article/44693891f10e4ceb81242eb3a4e99613
Autor:
Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We i
Externí odkaz:
https://doaj.org/article/0ae9f541650a4de1829a089cf962e69c
Autor:
Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson, Michael R. H. White, Pawel Paszek
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and su
Externí odkaz:
https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e
Autor:
Catherine Martin, Songbi Chen, Daniela Heilos, Guido Sauer, Jessica Hunt, Alexander George Shaw, Paul Francis George Sims, Dean Andrew Jackson, Josip Lovrić
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13322 (2010)
The Raf/ERK (Extracellular Signal Regulated Kinase) signal transduction pathway controls numerous cellular processes, including growth, differentiation, cellular transformation and senescence. ERK activation is thought to involve complex spatial and
Externí odkaz:
https://doaj.org/article/da220cc486d743a0b11dce1bd2461624
Autor:
Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in immunology 10, 2168 (2019). doi:10.3389/fimmu.2019.02168
Papoutsopoulou, S, Burkitt, M D, Bergey, F, England, H, Rachel, H, Schmidt, L, Spiller, D, White, M, Paszek, P, Jackson, D, Martins Dos Santos, V A P, Selge, G, Prittchard, M D, Campbell, B J, Muller, W & Probert, C S 2019, ' Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients ', Frontiers in Immunology, vol. 10, pp. 2168 . https://doi.org/10.3389/fimmu.2019.02168
Frontiers in Immunology, 10
Frontiers in Immunology 10 (2019)
FRONTIERS IN IMMUNOLOGY
Frontiers in Immunology
Frontiers in immunology 10, 2168 (2019). doi:10.3389/fimmu.2019.02168
Papoutsopoulou, S, Burkitt, M D, Bergey, F, England, H, Rachel, H, Schmidt, L, Spiller, D, White, M, Paszek, P, Jackson, D, Martins Dos Santos, V A P, Selge, G, Prittchard, M D, Campbell, B J, Muller, W & Probert, C S 2019, ' Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients ', Frontiers in Immunology, vol. 10, pp. 2168 . https://doi.org/10.3389/fimmu.2019.02168
Frontiers in Immunology, 10
Frontiers in Immunology 10 (2019)
FRONTIERS IN IMMUNOLOGY
Frontiers in Immunology
The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly-regulated, dynamic event in IBD pathogenesis. We expressed the human NF-κ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355aad654d10fc463161a059596b14da
https://doi.org/10.3389/fimmu.2019.02168
https://doi.org/10.3389/fimmu.2019.02168
Publikováno v:
Europe PubMed Central
Biogerontology
McPhee, J S, French, D P, Jackson, D, Nazroo, J, Pendleton, N & Degens, H 2016, ' Physical activity in older age : perspectives for healthy ageing and frailty ', Biogerontology, vol. 17, no. 3, pp. 567-80 . https://doi.org/10.1007/s10522-016-9641-0
Biogerontology
McPhee, J S, French, D P, Jackson, D, Nazroo, J, Pendleton, N & Degens, H 2016, ' Physical activity in older age : perspectives for healthy ageing and frailty ', Biogerontology, vol. 17, no. 3, pp. 567-80 . https://doi.org/10.1007/s10522-016-9641-0
Regular physical activity helps to improve physical and mental functions as well as reverse some effects of chronic disease to keep older people mobile and independent. Despite the highly publicised benefits of physical activity, the overwhelming maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8764fd31b51c8410640af9eb3924b673
https://doi.org/10.1007/s10522-016-9641-0
https://doi.org/10.1007/s10522-016-9641-0
Autor:
Pawel Paszek, Christopher M. Clark, Dean A. Jackson, Nissrin Alachkar, James Bagnall, James Roberts, Mark Muldoon, Hazel England, Mark Platt, William Rowe
Publikováno v:
Bagnall, J, Rowe, W, Alachkar, N, Roberts, J, England, H, Clark, C, Platt, M, Jackson, D, Muldoon, M & Paszek, P 2020, ' Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling ', Cell Systems, vol. 11, no. 3, pp. 300-314.e8 . https://doi.org/10.1016/j.cels.2020.08.007
Summary Single-cell gene expression is inherently variable, but how this variability is controlled in response to stimulation remains unclear. Here, we use single-cell RNA-seq and single-molecule mRNA counting (smFISH) to study inducible gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895227e99b0e9bf89e5f102871fee92e
https://doi.org/10.1016/j.cels.2020.08.007
https://doi.org/10.1016/j.cels.2020.08.007