Zobrazeno 1 - 10
of 967
pro vyhledávání: '"Dean A Jackson"'
Autor:
Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We i
Externí odkaz:
https://doaj.org/article/0ae9f541650a4de1829a089cf962e69c
Autor:
Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach,
Externí odkaz:
https://doaj.org/article/d581931c5d434a78a70223703dfa1143
Autor:
Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson, Michael R. H. White, Pawel Paszek
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and su
Externí odkaz:
https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e
Autor:
John M Ankers, Raheela Awais, Nicholas A Jones, James Boyd, Sheila Ryan, Antony D Adamson, Claire V Harper, Lloyd Bridge, David G Spiller, Dean A Jackson, Pawel Paszek, Violaine Sée, Michael RH White
Publikováno v:
eLife, Vol 5 (2016)
Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are prioritised di
Externí odkaz:
https://doaj.org/article/c93dc22ec0694d76b838a26b6974d89e
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Expression of ABC family transporter proteins that promote drug efflux from cancer cells is a widely observed mechanism of multi-drug resistance of cancer cells. Cell adaptation in long-term culture of HL60 leukemic cells in the presence of chemother
Externí odkaz:
https://doaj.org/article/e3008cb0937a43049b46eef53a325d2f
Publikováno v:
U.S. Black Engineer & Information Technology. Summer2012, Vol. 36 Issue 2, p7-7. 1/2p.
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77015 (2013)
Induction of genes is rarely an isolated event; more typically occurring as part of a web of parallel interactions, or motifs, which act to refine and control gene expression. Here, we define an Incoherent Feed-forward Loop motif in which TNFα-induc
Externí odkaz:
https://doaj.org/article/80019ac242d04425bf24a7d984350f62
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e27527 (2011)
The distribution of chromatin within the mammalian nucleus is constrained by its organization into chromosome territories (CTs). However, recent studies have suggested that promiscuous intra- and inter-chromosomal interactions play fundamental roles
Externí odkaz:
https://doaj.org/article/c11f9fddfdc4403a817b5d59cc238b9d