ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Autor: Oliver J. Mainwaring, Holger Weishaupt, Miao Zhao, Gabriela Rosén, Anna Borgenvik, Laura Breinschmid, Annemieke D. Verbaan, Stacey Richardson, Dean Thompson, Steven C. Clifford, Rebecca M. Hill, Karl Annusver, Anders Sundström, Karl O. Holmberg, Maria Kasper, Sonja Hutter, Fredrik J. Swartling

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

CDKN2A loss and p53 mutations are rare in MYC-driven Group 3 medulloblastomas (MBs). Here the authors generated a transgenic mouse model of Group 3 MB by MYC overexpression and show that MYC suppresses ARF to drive tumorigenesis.

Externí odkaz: https://doaj.org/article/15ce094130ad4d1185c37a3fd0a60446

Exploration of the uptake of asymptomatic COVID-19 lateral flow testing in Birmingham, UK: survey and qualitative research

Autor: Jonathan Mathers, Christopher Poyner, Gavin Rudge, Ruth V Pritchett, Dean Thompson

Publikováno v: BMJ Open, Vol 12, Iss 4 (2022)

Aim To examine public perspectives on lateral flow testing (LFT) for COVID-19.Design Online survey with nested semi-structured interviews.Setting Birmingham, UK.Participants 220 Birmingham residents, 21 of whom took part in an interview.Results Fifty

Externí odkaz: https://doaj.org/article/efe5ffec03b24aabbd461be7da6c4ef2

Loss of ALK hotspot mutations in relapsed neuroblastoma

Autor: Lisa M. Allinson, Aaron Potts, Angharad Goodman, Nick Bown, Matthew Bashton, Dean Thompson, Nermine O. Basta, Alem S. Gabriel, Michael McCorkindale, Antony Ng, Richard J. Q. McNally, Deborah A. Tweddle

Publikováno v: Genes, Chromosomes and Cancer. 61:747-753

ALK is the most commonly mutated oncogene in neuroblastoma with increased mutation frequency reported at relapse. Here we report the loss of an ALK mutation in two patients at relapse and a paired neuroblastoma cell line at relapse.\ud \ud ALK detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280d0271570186e27d5d0f124b17de3b
https://doi.org/10.1002/gcc.23093

OMIC-06. Molecular subgrouping of medulloblastoma via low-depth Whole Genome Bisulfite Sequencing

Autor: Steve Clifford, Dean Thompson, Jemma Castle, Edward C. Schwalbe, Debbie Hicks

Publikováno v: Neuro-Oncology

Introduction International consensus recognises four molecular subgroups of medulloblastoma, each with distinct molecular features and clinical outcomes. The current gold-standard for subgroup assignment is DNA methylation microarray. There is an unm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a1ac2d6194850df17a987196cc9e44
https://nrl.northumbria.ac.uk/id/eprint/46418/1/noab090.153.pdf

Phylogenomic Classification and Biosynthetic Potential of the Fossil Fuel-Biodesulfurizing Rhodococcus Strain IGTS8

Autor: Christine Carapito, Wael Ismail, Sandrine Koechler, Alain Van Dorsselaer, Michael Goodfellow, Dimitri Heintz, Valérie Cognat, Vartul Sangal, Dean Thompson, Huda Mahmoud

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, Frontiers Media, 2020, 11, ⟨10.3389/fmicb.2020.01417⟩
Frontiers in Microbiology, Vol 11 (2020)

International audience; Rhodococcus strain IGTS8 is the most extensively studied model bacterium for biodesulfurization of fossil fuels via the non-destructive sulfur-specific 4S pathway. This strain was initially assigned to Rhodococcus rhodochrous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63367a40ec08f24975a32d64e81633e
https://hal.archives-ouvertes.fr/hal-03024721