Výsledky vyhledávání - "Dean, Bottino"

Akademický článek

Modeling serum M‐protein response for early detection of biochemical relapse in myeloma patients treated with bortezomib, lenalidomide and dexamethasone

Autor: Yuki Otani, Yunqi Zhao, Guanyu Wang, Richard Labotka, Mark Rogge, Neeraj Gupta, Majid Vakilynejad, Dean Bottino, Yusuke Tanigawara

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 12, Pp 2124-2136 (2024)

Abstract Multiple myeloma (MM) treatment guidelines recommend waiting for formal progression criteria (FPC) to be met before proceeding to the next line of therapy. As predicting progression may allow early switching to next‐line therapy while the

Externí odkaz: https://doaj.org/article/862531faf736495183488735ded1aa0e

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Akademický článek

Heterogeneity in Vaccinal Immunity to SARS-CoV-2 Can Be Addressed by a Personalized Booster Strategy

Autor: Madison Stoddard, Lin Yuan, Sharanya Sarkar, Shruthi Mangalaganesh, Ryan P. Nolan, Dean Bottino, Greg Hather, Natasha S. Hochberg, Laura F. White, Arijit Chakravarty

Publikováno v: Vaccines, Vol 11, Iss 4, p 806 (2023)

SARS-CoV-2 vaccinations were initially shown to substantially reduce risk of severe disease and death. However, pharmacokinetic (PK) waning and rapid viral evolution degrade neutralizing antibody (nAb) binding titers, causing loss of vaccinal protect

Externí odkaz: https://doaj.org/article/96a245fc87ee4429b1fd2755184c4612

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Akademický článek

Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making

Autor: Anna Kondic, Dean Bottino, John Harrold, Jeffrey D. Kearns, CJ Musante, Aleksandrs Odinecs, Saroja Ramanujan, Jangir Selimkhanov, Birgit Schoeberl

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided

Externí odkaz: https://doaj.org/article/cc2e644a24a548b9a118216b30197d39

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A comprehensive regulatory and industry review of modeling and simulation practices in oncology clinical drug development

Autor: Ana Ruiz-Garcia, Paul Baverel, Dean Bottino, Michael Dolton, Yan Feng, Ignacio González-García, Jaeyeon Kim, Seth Robey, Indrajeet Singh, David Turner, Shu-Pei Wu, Donghua Yin, Di Zhou, Hao Zhu, Peter Bonate

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 50:147-172

Exposure–response (E–R) analyses are an integral component in the development of oncology products. Characterizing the relationship between drug exposure metrics and response allows the sponsor to use modeling and simulation to address both inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::930dfc175ba48c8b30148ee26bbd619d
https://doi.org/10.1007/s10928-023-09850-2

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Data from BCR–ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment

Autor: Andreas Hochhaus, Jerald P. Radich, Timothy P. Hughes, John M. Goldman, Jaspal Kaeda, Susan Branford, Vijay Modur, Dean Bottino, Andrew M. Stein

Purpose: Imatinib induces a durable response in most patients with Philadelphia chromosome–positive chronic myeloid leukemia, but it is currently unclear whether imatinib reduces the leukemic stem cell (LSC) burden, which may be an important step t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818ca19e251e937b8a9b69d9a84312dd
https://doi.org/10.1158/1078-0432.c.6519950

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